Oleanolic Acid and Ursolic Acid Induce Apoptosis in HuH7 Human Hepatocellular Carcinoma Cells through a Mitochondrial-Dependent Pathway and Downregulation of XIAP

Ming-Huan Shyu; Tzu-Chien Kao; Gow-Chin Yen

doi:10.1021/jf100574j

Oleanolic Acid and Ursolic Acid Induce Apoptosis in HuH7 Human Hepatocellular Carcinoma Cells through a Mitochondrial-Dependent Pathway and Downregulation of XIAP

Journal of Agricultural and Food Chemistry ◽

10.1021/jf100574j ◽

2010 ◽

Vol 58 (10) ◽

pp. 6110-6118 ◽

Cited By ~ 111

Author(s):

Ming-Huan Shyu ◽

Tzu-Chien Kao ◽

Gow-Chin Yen

Keyword(s):

Hepatocellular Carcinoma ◽

Ursolic Acid ◽

Oleanolic Acid ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells ◽

Dependent Pathway

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Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells

Biochemical Pharmacology ◽

10.1016/j.bcp.2016.08.011 ◽

2016 ◽

Vol 118 ◽

pp. 9-17 ◽

Cited By ~ 18

Author(s):

Matthias Lange ◽

Behnaz Ahangarian Abhari ◽

Tobias M. Hinrichs ◽

Simone Fulda ◽

Juliane Liese

Keyword(s):

Oxidative Stress ◽

Hepatocellular Carcinoma ◽

Cell Death ◽

Oleanolic Acid ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells

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Smac mimetic and oleanolic acid synergize to induce cell death in human hepatocellular carcinoma cells

Cancer Letters ◽

10.1016/j.canlet.2015.04.018 ◽

2015 ◽

Vol 365 (1) ◽

pp. 47-56 ◽

Cited By ~ 18

Author(s):

Juliane Liese ◽

Behnaz Ahangarian Abhari ◽

Simone Fulda

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Death ◽

Oleanolic Acid ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Induce Cell Death ◽

Smac Mimetic ◽

Human Hepatocellular Carcinoma Cells

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Induction of apoptosis by an oleanolic acid derivative in SMMC-7721 human hepatocellular carcinoma cells is associated with mitochondrial dysfunction

Oncology Letters ◽

10.3892/ol.2017.7653 ◽

2017 ◽

Author(s):

Xinfeng Fan ◽

Penglong Wang ◽

Yaogui Sun ◽

Junbing Jiang ◽

Haiyuan Du ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Mitochondrial Dysfunction ◽

Acid Derivative ◽

Oleanolic Acid ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Induction Of Apoptosis ◽

Human Hepatocellular Carcinoma Cells ◽

Oleanolic Acid Derivative

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Bear bile powder (熊胆粉) induces apoptosis of human hepatocellular carcinoma cells via mitochondrion-dependent pathway

Chinese Journal of Integrative Medicine ◽

10.1007/s11655-013-1581-9 ◽

2014 ◽

Vol 20 (2) ◽

pp. 123-129 ◽

Cited By ~ 4

Author(s):

Jin-yan Zhao ◽

Zhi-hong Chen ◽

Wei Lin ◽

Xiao-yong Zhong ◽

Xu-zheng Chen ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Bear Bile ◽

Bear Bile Powder ◽

Human Hepatocellular Carcinoma Cells ◽

Dependent Pathway

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Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression

Amino Acids ◽

10.1007/s00726-014-1838-4 ◽

2014 ◽

Vol 46 (12) ◽

pp. 2809-2822 ◽

Cited By ~ 46

Author(s):

Shu-Ching Hsieh ◽

Jen-Pi Tsai ◽

Shun-Fa Yang ◽

Meng-Ju Tang ◽

Yi-Hsien Hsieh

Keyword(s):

Hepatocellular Carcinoma ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells ◽

Dependent Pathway

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SCYL1-BP1 Affects Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells via Cyclin F and RRM2

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520615666150518093814 ◽

2016 ◽

Vol 16 (4) ◽

pp. 440-446 ◽

Cited By ~ 3

Author(s):

Yang Wang ◽

Qiaoming Zhi ◽

Qin Ye ◽

Chengyuan Zhou ◽

Lei Zhang ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Cycle ◽

Cell Cycle Arrest ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Cycle Arrest ◽

Cyclin F ◽

Human Hepatocellular Carcinoma Cells

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C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function

Acta Pharmacologica Sinica ◽

10.1038/s41401-021-00642-3 ◽

2021 ◽

Author(s):

Ahmed Attia Ahmed Abdelmoaty ◽

Ping Zhang ◽

Wen Lin ◽

Ying-juan Fan ◽

Sheng-nan Ye ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells ◽

Hsp90 Function ◽

Curcumin Derivative

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Expression of Concern to: Downregulation of NIN/RPN12 binding protein inhibit the growth of human hepatocellular carcinoma cells

Molecular Biology Reports ◽

10.1007/s11033-021-06320-1 ◽

2021 ◽

Author(s):

Zaiming Lu ◽

Qiyong Guo ◽

Aizhong Shi ◽

Feng Xie ◽

Qingjie Lu

Keyword(s):

Hepatocellular Carcinoma ◽

Binding Protein ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells

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Withdrawal: Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells

Journal of Biological Chemistry ◽

10.1016/j.jbc.2021.100762 ◽

2021 ◽

Vol 296 ◽

pp. 100762

Author(s):

Lianjun Yang ◽

Nan Li ◽

Chunmei Wang ◽

Yizhi Yu ◽

Liang Yuan ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Rna Polymerase ◽

Rna Polymerase Ii ◽

Carcinoma Cells ◽

Mrna Splicing ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells

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Reduction of anion exchanger 2 expression induces apoptosis of human hepatocellular carcinoma cells

Molecular and Cellular Biochemistry ◽

10.1007/s11010-009-0051-3 ◽

2009 ◽

Vol 327 (1-2) ◽

pp. 135-144 ◽

Cited By ~ 19

Author(s):

Jin-Ming Hwang ◽

Shao-Hsuan Kao ◽

Yi-Hsien Hsieh ◽

Kuen-Lin Li ◽

Pei-Hsi Wang ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Anion Exchanger ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Anion Exchanger 2 ◽

Human Hepatocellular Carcinoma Cells

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