1,4,2-Benzo/pyridodithiazine 1,1-Dioxides Structurally Related to the ATP-Sensitive Potassium Channel Openers 1,2,4-Benzo/pyridothiadiazine 1,1-Dioxides Exert a Myorelaxant Activity Linked to a Distinct Mechanism of Action

2013 ◽  
Vol 56 (8) ◽  
pp. 3247-3256 ◽  
Author(s):  
Bernard Pirotte ◽  
Pascal de Tullio ◽  
Xavier Florence ◽  
Eric Goffin ◽  
Fabian Somers ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Mechanism Of Action ◽  
Potassium Channel Openers ◽  
Distinct Mechanism

scholarly journals Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice

2010 ◽  
Vol 4 ◽  
pp. SART.S6211 ◽  
Author(s):  
Vikas Seth ◽  
Mushtaq Ahmad ◽  
Prerna Upadhyaya ◽  
Monika Sharma ◽  
Vijay Moghe
Keyword(s):  
Potassium Channel ◽  
Withdrawal Syndrome ◽  
Channel Blocker ◽  
Inhibitory Effect ◽  
Morphine Withdrawal ◽  
The Other ◽  
Opioid Antagonist ◽  
Potassium Channel Openers ◽  
Potassium Channel Modulators ◽  
Withdrawal Signs

The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced by using an opioid antagonist, naloxone. Mice were observed for 30 minutes for the withdrawal signs ie, the characteristic jumping, hyperactivity, urination and diarrhea. ATP-dependent potassium (K+ATP) channel modulators were injected intraperitoneally (i.p.) 30 minutes before the naloxone. It was found that a K+ATP channel opener, minoxidil (12.5–50 mg/kg i.p.), suppressed the morphine withdrawal significantly. On the other hand, the K+ATP channel blocker glibenclamide (12.5–50 mg/kg i.p.) caused a significant facilitation of the withdrawal. Glibenclamide was also found to abolish the minoxidil's inhibitory effect on morphine withdrawal. The study concludes that K+ATP channels play an important role in the genesis of morphine withdrawal and K+ATP channel openers could be useful in the management of opioid withdrawal. As morphine opens K+ATP channels in neurons, the channel openers possibly act by mimicking the effects of morphine on neuronal K+ currents.

scholarly journals Big conductance calcium-activated potassium channel openers control spasticity without sedation

2017 ◽  
Vol 174 (16) ◽  
pp. 2662-2681 ◽  
Author(s):  
David Baker ◽  
Gareth Pryce ◽  
Cristina Visintin ◽  
Sofia Sisay ◽  
Alexander I Bondarenko ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Potassium Channel Openers ◽  
Calcium Activated Potassium Channel

scholarly journals Interaction of potassium channel openers with glioma cells mitochondria

2003 ◽  
Vol 85 ◽  
pp. 36-36
Author(s):  
G. Dębska ◽  
A. Kicińska ◽  
J. Skalska ◽  
A. Szewczyk
Keyword(s):  
Potassium Channel ◽  
Glioma Cells ◽  
Potassium Channel Openers

scholarly journals The Phosphoenolpyruvate:Sugar Phosphotransferase System Is Involved in Sensitivity to the Glucosylated Bacteriocin Sublancin

2015 ◽  
Vol 59 (11) ◽  
pp. 6844-6854 ◽  
Author(s):  
C. V. Garcia De Gonzalo ◽  
E. L. Denham ◽  
R. A. T. Mars ◽  
J. Stülke ◽  
W. A. van der Donk ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mechanism Of Action ◽  
Mode Of Action ◽  
Phosphotransferase System ◽  
Content Type ◽  
Gram Positive Bacteria ◽  
Distinct Mechanism ◽  
Genomic Studies ◽  
Increased Sensitivity ◽  
Bacterial Sensitivity

ABSTRACTThe mode of action of a group of glycosylated antimicrobial peptides known as glycocins remains to be elucidated. In the current study of one glycocin, sublancin, we identified the phosphoenolpyruvate:sugar phosphotransferase system (PTS) ofBacillusspecies as a key player in bacterial sensitivity. Sublancin kills several Gram-positive bacteria, such asBacillusspecies andStaphylococcus aureus, including methicillin-resistantS. aureus(MRSA). Unlike other classes of bacteriocins for which the PTS is involved in their mechanism of action, we show that the addition of PTS-requiring sugars leads to increased resistance rather than increased sensitivity, suggesting that sublancin has a distinct mechanism of action. Collectively, our present mutagenesis and genomic studies demonstrate that the histidine-containing phosphocarrier protein (HPr) and domain A of enzyme II (PtsG) in particular are critical determinants for bacterial sensitivity to sublancin.

Potassium-Channel Openers KMUP-1 and Pinacidil Prevent Subarachnoid Hemorrhage–Induced Vasospasm by Restoring the BKCa-Channel Activity

Shock ◽  
2012 ◽  
Vol 38 (2) ◽  
pp. 203-212 ◽  
Author(s):  
Jun-Yih Chen ◽  
Kuang-I Cheng ◽  
Yi-Lin Tsai ◽  
Yi-Ren Hong ◽  
Shen-Long Howng ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Potassium Channel ◽  
Bkca Channel ◽  
Channel Activity ◽  
Potassium Channel Openers
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