Effects of the potassium channel openers KRN4884 and levcromakalim on the contraction of rat aorta induced by A23187, compared with nifedipine

1996 ◽  
Vol 354 (4) ◽  
pp. 460-465 ◽  
Author(s):  
Jun-ichi Kawahara ◽  
Hideakira Izumi ◽  
Yuji Okada ◽  
Toshio Izawa
Keyword(s):  
Potassium Channel ◽  
Rat Aorta ◽  
Potassium Channel Openers

Differential sensitivity to ATP-sensitive potassium channel openers of norepinephrine-induced contraction of guinea pig and rat aorta

Life Sciences ◽  
1998 ◽  
Vol 62 (24) ◽  
pp. 2171-2179 ◽  
Author(s):  
Wataru Saito ◽  
Miwako Aida ◽  
Minoru Sasaki ◽  
Yayoi Saito ◽  
Yoshio Tanaka ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Potassium Channel ◽  
Rat Aorta ◽  
Differential Sensitivity ◽  
Potassium Channel Openers

scholarly journals Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice

2010 ◽  
Vol 4 ◽  
pp. SART.S6211 ◽  
Author(s):  
Vikas Seth ◽  
Mushtaq Ahmad ◽  
Prerna Upadhyaya ◽  
Monika Sharma ◽  
Vijay Moghe
Keyword(s):  
Potassium Channel ◽  
Withdrawal Syndrome ◽  
Channel Blocker ◽  
Inhibitory Effect ◽  
Morphine Withdrawal ◽  
The Other ◽  
Opioid Antagonist ◽  
Potassium Channel Openers ◽  
Potassium Channel Modulators ◽  
Withdrawal Signs

The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced by using an opioid antagonist, naloxone. Mice were observed for 30 minutes for the withdrawal signs ie, the characteristic jumping, hyperactivity, urination and diarrhea. ATP-dependent potassium (K+ATP) channel modulators were injected intraperitoneally (i.p.) 30 minutes before the naloxone. It was found that a K+ATP channel opener, minoxidil (12.5–50 mg/kg i.p.), suppressed the morphine withdrawal significantly. On the other hand, the K+ATP channel blocker glibenclamide (12.5–50 mg/kg i.p.) caused a significant facilitation of the withdrawal. Glibenclamide was also found to abolish the minoxidil's inhibitory effect on morphine withdrawal. The study concludes that K+ATP channels play an important role in the genesis of morphine withdrawal and K+ATP channel openers could be useful in the management of opioid withdrawal. As morphine opens K+ATP channels in neurons, the channel openers possibly act by mimicking the effects of morphine on neuronal K+ currents.

scholarly journals Big conductance calcium-activated potassium channel openers control spasticity without sedation

2017 ◽  
Vol 174 (16) ◽  
pp. 2662-2681 ◽  
Author(s):  
David Baker ◽  
Gareth Pryce ◽  
Cristina Visintin ◽  
Sofia Sisay ◽  
Alexander I Bondarenko ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Potassium Channel Openers ◽  
Calcium Activated Potassium Channel

scholarly journals Interaction of potassium channel openers with glioma cells mitochondria

2003 ◽  
Vol 85 ◽  
pp. 36-36
Author(s):  
G. Dębska ◽  
A. Kicińska ◽  
J. Skalska ◽  
A. Szewczyk
Keyword(s):  
Potassium Channel ◽  
Glioma Cells ◽  
Potassium Channel Openers

Potassium-Channel Openers KMUP-1 and Pinacidil Prevent Subarachnoid Hemorrhage–Induced Vasospasm by Restoring the BKCa-Channel Activity

Shock ◽  
2012 ◽  
Vol 38 (2) ◽  
pp. 203-212 ◽  
Author(s):  
Jun-Yih Chen ◽  
Kuang-I Cheng ◽  
Yi-Lin Tsai ◽  
Yi-Ren Hong ◽  
Shen-Long Howng ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Potassium Channel ◽  
Bkca Channel ◽  
Channel Activity ◽  
Potassium Channel Openers
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