Quantitative and Site-Directed Chemical Modification of Hypocrellins toward Direct Drug Delivery and Effective Photodynamic Activity

2012 ◽  
Vol 55 (5) ◽  
pp. 1910-1919 ◽  
Author(s):  
Hong Deng ◽  
Xin Liu ◽  
Jie Xie ◽  
Rong Yin ◽  
Naiyan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Photodynamic Activity

scholarly journals CHEMICAL MODIFICATION, CHARACTERIZATION AND EVALUATION OF MUCOADHESIVE POTENTIALITY OF ASSAM BORA RICE STARCH

2017 ◽  
Vol 9 (9) ◽  
pp. 132 ◽  
Author(s):  
Abdul Baquee Ahmed ◽  
Iman Bhaduri
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Chemical Modification ◽  
Ex Vivo ◽  
Rice Starch ◽  
Modified Starch ◽  
Native Starch ◽  
Ft Ir

Objective: The objective of the present study was to chemical modification, characterization and evaluation of mucoadhesive potentiality of Assam bora rice starch as potential excipients in the sustained release drug delivery system. Methods: The starch was isolated from Assam bora rice and esterified using thioglycolic acid and characterized by Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and Nuclear magnetic resonance (NMR). The 10% w/v gel formulation based on modified bora rice starch loaded with irinotecan (0.6%) was prepared and evaluated for various rheological properties, ex-vivo mucoadhesion using goat intestine and in vitro drug release study in phosphate buffer pH 6.8.Results: The chemical modification was confirmed by FT-IR and NMR studies with the presence of the peak at 2626.74 cm-1 and a singlet at 2.51 respectively due to–SH group. Ex-vivo mucoadhesion studies showed 6.6 fold increases in mucoadhesion of the modified starch with compared to native starch (46.3±6.79g for native starch; 308.7±95.31g for modified starch). In vitro study showed 89.12±0.84 % of drug release after 6 h in phosphate buffer pH 6.8 and the release kinetics followed Non-Fickian diffusion.Conclusion: The modified Assam bora rice starch enhanced a mucoadhesive property of the native starch and thus, can be explored in future as a potential excipient for the sustained release mucoadhesive drug delivery system.

Chemical modification of enveloped viruses for biomedical applications

2018 ◽  
Vol 10 (11) ◽  
pp. 666-679 ◽  
Author(s):  
Pahweenvaj Ratnatilaka Na Bhuket ◽  
Jittima Amie Luckanagul ◽  
Pornchai Rojsitthisak ◽  
Qian Wang
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Biomedical Applications ◽  
Vaccine Development ◽  
Enveloped Viruses ◽  
Bio Imaging

Chemistry enables scientists to use enveloped viruses in several biomedical applications including bio-imaging, drug delivery and vaccine development.

Enhancing Drug Delivery by Chemical Modification

2008 ◽  
pp. 191-205
Author(s):  
Mimoun Ayoub ◽  
Christina Wedemeyer ◽  
Torsten Wöhr
Keyword(s):  
Drug Delivery ◽  
Chemical Modification

Recent progress of liposomes in nanomedicine

2014 ◽  
Vol 2 (39) ◽  
pp. 6686-6691 ◽  
Author(s):  
Leticia Hosta-Rigau ◽  
Philipp Schattling ◽  
Boon M. Teo ◽  
Martin E. Lynge ◽  
Brigitte Städler
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Recent Progress

Liposome formulations are highlighted focusing on their chemical modification, interaction with cells, and use in substrate-mediated drug delivery and cell mimicry.

scholarly journals PROPERTIES, PHARMACEUTICAL APPLICATION AND VARIOUS TECHNIQUE OF CHEMICAL MODIFICATION IN NATIVE STARCH: A DESCRIPTIVE REVIEW

2019 ◽  
pp. 54-59
Author(s):  
BISHAL JYOTI BORDOLOI ◽  
BHUPEN KALITA ◽  
DIBYENDU SHIL
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
The Body ◽  
Gelling Agent ◽  
Intrinsic Properties ◽  
Pharmaceutical Application ◽  
Conventional Drug ◽  
Wide Range ◽  
Thickening Power ◽  
And Storage

Starch is one important natural polymer that finds application in the formulation of dosage forms as the binder, disintegrates, diluents, gelling agent etc. Starch is drawing the attention in drug delivery as it is cheap, non-toxic, renewable, biodegradable and compatible with many other materials for industrial application. Starch has vital intrinsic properties that have made its pharmaceutical applications possible. It has also been used for a wide range of particular drug delivery applications, such as the delivery of challenging molecules and targeting to specific sites in the body. Starches are integrally unsuitable for most applications such as loss of viscosity and thickening power upon cooking and storage, retrogradation characteristics and absence of certain groups responsible for a particular function etc. So, in order to reduce its limitations and improve its applications, modification of starch is necessary. It can be modified by several ways like chemical modification, physical modification and genetic modification but the most important one is the chemical modification. This review summarizes the properties and application of native starchin conventional drug delivery systems within a world of dynamic drug production technology. It also describes the chemical modification like cross-linking, esterification, etherification and dual modification of starch.

ChemInform Abstract: Chemical Modification of Hyaluronic Acid for Drug Delivery, Biomaterials and Biochemical Probes

ChemInform ◽  
2010 ◽  
Vol 29 (46) ◽  
pp. no-no ◽  
Author(s):  
G. D. PRESTWICH ◽  
D. M. MARECAK ◽  
J. F. MARECEK ◽  
K. P. VERCRUYSSE ◽  
M. R. ZIEBELL
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Chemical Modification
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