Fragment-Based Design of Symmetrical Bis-benzimidazoles as Selective Inhibitors of the Trimethoprim-Resistant, Type II R67 Dihydrofolate Reductase

2012 ◽  
Vol 55 (7) ◽  
pp. 3182-3192 ◽  
Author(s):  
Dominic Bastien ◽  
Maximilian C. C. J. C. Ebert ◽  
Delphine Forge ◽  
Jacynthe Toulouse ◽  
Natalia Kadnikova ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Type Ii ◽  
Selective Inhibitors ◽  
R67 Dihydrofolate Reductase

Role of Ionic Interactions in Ligand Binding and Catalysis of R67 Dihydrofolate Reductase†

Biochemistry ◽  
2003 ◽  
Vol 42 (36) ◽  
pp. 10569-10578 ◽  
Author(s):  
Stephanie N. Hicks ◽  
R. Derike Smiley ◽  
J. Bradley Hamilton ◽  
Elizabeth E. Howell
Keyword(s):  
Ligand Binding ◽  
Dihydrofolate Reductase ◽  
Ionic Interactions ◽  
R67 Dihydrofolate Reductase

scholarly journals Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues

ACS Omega ◽  
2019 ◽  
Vol 4 (6) ◽  
pp. 10056-10069 ◽  
Author(s):  
Jacynthe L. Toulouse ◽  
Brahm J. Yachnin ◽  
Edward H. Ruediger ◽  
Daniel Deon ◽  
Marc Gagnon ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Type Ii ◽  
Dimeric Bisbenzimidazole

Does R67 Dihydrofolate Reductase Possess a Proton Donor?

1993 ◽  
pp. 493-498 ◽  
Author(s):  
Janel C. Holland ◽  
Charles E. Linn ◽  
Enrico DiGiammarino ◽  
Robert Nichols ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
Proton Donor ◽  
R67 Dihydrofolate Reductase

scholarly journals Role of Lys-32 Residues in R67 Dihydrofolate Reductase Probed by Asymmetric Mutations

2004 ◽  
Vol 279 (45) ◽  
pp. 46995-47002 ◽  
Author(s):  
Stephanie N. Hicks ◽  
R. Derike Smiley ◽  
Lori G. Stinnett ◽  
Kenneth H. Minor ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

Interligand Overhauser Effects in Type II Dihydrofolate Reductase

Biochemistry ◽  
2001 ◽  
Vol 40 (14) ◽  
pp. 4242-4252 ◽  
Author(s):  
Dawei Li ◽  
Louis A. Levy ◽  
Scott A. Gabel ◽  
Mark S. Lebetkin ◽  
Eugene F. DeRose ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Type Ii

The structure-based design and synthesis of selective inhibitors of trypanosoma cruzi dihydrofolate reductase

1999 ◽  
Vol 9 (10) ◽  
pp. 1463-1468 ◽  
Author(s):  
Fabio Zuccotto ◽  
Reto Brun ◽  
Dolores Gonzalez Pacanowska ◽  
Luis M. Ruiz Perez ◽  
Ian H. Gilbert
Keyword(s):  
Trypanosoma Cruzi ◽  
Dihydrofolate Reductase ◽  
Selective Inhibitors ◽  
Design And Synthesis

Further Studies on the Role of Water in R67 Dihydrofolate Reductase

Biochemistry ◽  
2013 ◽  
Vol 52 (12) ◽  
pp. 2118-2127 ◽  
Author(s):  
Mary Jane Timson ◽  
Michael R. Duff ◽  
Greyson Dickey ◽  
Arnold M. Saxton ◽  
José I. Reyes-De-Corcuera ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

Prevalence of a plasmid-mediated type II dihydrofolate reductase gene among trimethoprim-resistant urinary pathogens in Greek hospitals

1992 ◽  
Vol 29 (4) ◽  
pp. 405-413 ◽  
Author(s):  
A. Tsakris ◽  
A. C. Vatopoulos ◽  
A. P. Johnson ◽  
T. L. Pitt ◽  
N. J. Legakis ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Type Ii ◽  
Reductase Gene ◽  
Greek Hospitals
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