Fluorocyclines. 1. 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent

2012 ◽  
Vol 55 (2) ◽  
pp. 597-605 ◽  
Author(s):  
Xiao-Yi Xiao ◽  
Diana K. Hunt ◽  
Jingye Zhou ◽  
Roger B. Clark ◽  
Nick Dunwoody ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent

Repurposing of auranofin against bacterial infections: An In silico and In vitro study

2020 ◽  
Vol 16 ◽  
Author(s):  
Nidhi Sharma ◽  
Arti Singh ◽  
Ruchika Sharma ◽  
Anoop Kumar
Keyword(s):  
Broad Spectrum ◽  
In Silico ◽  
Antibacterial Agent ◽  
Bacterial Infections ◽  
In Vitro Assays ◽  
Infection Model ◽  
Synergistic Activity ◽  
Bacterial Strains ◽  
Molecular Docking Study

Aim: The aim of the study was to find out the role of auranofin as a promising broad spectrum antibacterial agent. Methods: In-vitro assays (Percentage growth retardation, Bacterial growth kinetics, Biofilm formation assay) and In-silico study (Molegro virtual docker (MVD) version 6.0 and Molecular operating environment (MOE) version 2008.10 software). Results: The in vitro assays have shown that auranofin has good antibacterial activity against Gram positive and Gram negative bacterial strains. Further, auranofin has shown synergistic activity in combination with ampicillin against S. aureus and B. subtilis whereas in combination with neomycin has just shown additive effect against E. coli, P. aeruginosa and B. pumilus. In vivo results have revealed that auranofin alone and in combination with standard drugs significantly decreased the bioburden in zebrafish infection model as compared to control. The molecular docking study have shown good interaction of auranofin with penicillin binding protein (2Y2M), topoisomerase (3TTZ), UDP-3-O-[3- hydroxymyristoyl] N-acetylglucosaminedeacetylase (3UHM), cell adhesion protein (4QRK), β-lactamase (5CTN) and arylsulphatase (1HDH) enzyme as that of reference ligand which indicate multimodal mechanism of action of auranofin. Finally, MTT assay has shown non-cytotoxic effect of auranofin. Conclusion: In conclusion, auranofin in combination with existing antibiotics could be developed as a broad spectrum antibacterial agent; however, further studies are required to confirm its safety and efficacy. This study provides possibility of use of auranofin apart from its established therapeutic indication in combination with existing antibiotics to tackle the problem of resistance.

scholarly journals Porphyrin−Apidaecin Conjugate as a New Broad Spectrum Antibacterial Agent

2010 ◽  
Vol 1 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Ryan Dosselli ◽  
Marina Gobbo ◽  
Erika Bolognini ◽  
Sandro Campestrini ◽  
Elena Reddi
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent

scholarly journals NB2001, a Novel Antibacterial Agent with Broad-Spectrum Activity and Enhanced Potency against β-Lactamase-Producing Strains

2002 ◽  
Vol 46 (5) ◽  
pp. 1262-1268 ◽  
Author(s):  
Qing Li ◽  
Jean Y. Lee ◽  
Rosario Castillo ◽  
Mark S. Hixon ◽  
Catherine Pujol ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Bacterial Resistance ◽  
Enterobacter Aerogenes ◽  
Order Rate Constant ◽  
Common Mechanism ◽  
E Coli ◽  
Lactam Ring ◽  
Spectrum Activity ◽  
Hydrolysis Of

ABSTRACT Enzyme-catalyzed therapeutic activation (ECTA) is a novel prodrug strategy to overcome drug resistance resulting from enzyme overexpression. β-Lactamase overexpression is a common mechanism of bacterial resistance to β-lactam antibiotics. We present here the results for one of the β-lactamase ECTA compounds, NB2001, which consists of the antibacterial agent triclosan in a prodrug form with a cephalosporin scaffold. Unlike conventional β-lactam antibiotics, where hydrolysis of the β-lactam ring inactivates the antibiotic, hydrolysis of NB2001 by β-lactamase releases triclosan. Evidence supporting the proposed mechanism is as follows. (i) NB2001 is a substrate for TEM-1 β-lactamase, forming triclosan with a second-order rate constant (k cat/Km ) of greater than 77,000 M−1 s−1. (ii) Triclosan is detected in NB2001-treated, β-lactamase-producing Escherichia coli but not in E. coli that does not express β-lactamase. (iii) NB2001 activity against β-lactamase-producing E. coli is decreased in the presence of the β-lactamase inhibitor clavulanic acid. NB2001 was similar to or more potent than reference antibiotics against clinical isolates of Staphylococcus aureus (including MRSA), Staphylococcus epidermidis, Streptococcus pneumoniae, vancomycin-resistant Enterococcus faecalis, Moraxella catarrhalis and Haemophilus influenzae. NB2001 is also active against Klebsiella pneumoniae, Enterobacter aerogenes, and Enterobacter cloacae. The results indicate that NB2001 is a potent, broad-spectrum antibacterial agent and demonstrate the potential of ECTA in overcoming β-lactamase-mediated resistance.

Antibacterial Activity Inhibition after the Degradation of Flumequine by UV/H2O2

2011 ◽  
Vol 14 (1) ◽  
Author(s):  
Caio Rodrigues da Silva ◽  
Milena Guedes Maniero ◽  
Susanne Rath ◽  
José Roberto Guimarães
Keyword(s):  
Antibacterial Activity ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Veterinary Drug ◽  
Drug Resistant ◽  
Bacterial Strains ◽  
Activity Inhibition

AbstractFlumequine is a broad-spectrum antibacterial agent of the quinolone class widely used as veterinary drug in food-producing animals. It is considered as pseudo-persistent compound continuously introduced into the environment and its presence in the environment may contribute to the development of drug resistant bacterial strains. In this study antibacterial activity removal during flumequine degradation by UV/H

Facile synthesis of monodisperse chromogenic amylose–iodine nanoparticles as an efficient broad-spectrum antibacterial agent

2020 ◽  
Vol 8 (15) ◽  
pp. 3010-3015
Author(s):  
Yanbin Sun ◽  
Xianwen Wang ◽  
Linxin Fan ◽  
Xianli Xie ◽  
Zhaohua Miao ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Near Infrared ◽  
Infrared Laser ◽  
Facile Synthesis ◽  
Infrared Laser Irradiation

Monodisperse chromogenic amylose–iodine nanoparticles were developed as an efficient broad-spectrum antibacterial agent under the assistance of near-infrared laser irradiation.

scholarly journals Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0183457 ◽  
Author(s):  
Abiodun D. Ogunniyi ◽  
Manouchehr Khazandi ◽  
Andrew J. Stevens ◽  
Sarah K. Sims ◽  
Stephen W. Page ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent

Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance

2015 ◽  
Vol 96 ◽  
pp. 152-161 ◽  
Author(s):  
M.S. Nieto-Bobadilla ◽  
F. Siepmann ◽  
M. Djouina ◽  
L. Dubuquoy ◽  
N. Tesse ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Controlled Delivery

scholarly journals Amino-Terminated Generation 2 Poly(amidoamine) Dendrimer as a Potential Broad-Spectrum, Nonresistance-Inducing Antibacterial Agent

2012 ◽  
Vol 15 (1) ◽  
pp. 132-142 ◽  
Author(s):  
Xiaoyan Xue ◽  
Xiaoqing Chen ◽  
Xinggang Mao ◽  
Zheng Hou ◽  
Ying Zhou ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent

Mandelamine and urinary infections

1963 ◽  
Vol 1 (8) ◽  
pp. 29-30
Keyword(s):  
Antibacterial Activity ◽  
Urinary Tract ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Mandelic Acid ◽  
Antibacterial Effect ◽  
Urinary Infections ◽  
Resistant Strains

Methenamine mandelate (Mandelamine - Warner), a combination of methenamine and mandelic acid, is promoted as a broad-spectrum antibacterial agent that can be used against chronic or recurrent urinary infections without the appearance of resistant strains. In the urine, the drug yields formaldehyde and mandelic acid, both of which act only in the urine and not at all in the tissues of the urinary tract. Mandelic acid has less antibacterial effect than formaldehyde, but causes some acidification of the urine. Each component requires a pH of 5. 5 or less in the urine for even moderate antibacterial activity, and a supplementary acidifying agent is usually necessary.

Sign in / Sign up

Export Citation Format

Share Document