Should we consider broad‐spectrum quinolone antibacterial agent as acne treatment in the antimicrobial resistance era?

2021 ◽  
Author(s):  
L. Ruffier d’Epenoux ◽  
A. Guillouzouic ◽  
P. Bémer ◽  
M‐A Dagnelie ◽  
A. Khammari ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Acne Treatment

Repurposing of auranofin against bacterial infections: An In silico and In vitro study

2020 ◽  
Vol 16 ◽  
Author(s):  
Nidhi Sharma ◽  
Arti Singh ◽  
Ruchika Sharma ◽  
Anoop Kumar
Keyword(s):  
Broad Spectrum ◽  
In Silico ◽  
Antibacterial Agent ◽  
Bacterial Infections ◽  
In Vitro Assays ◽  
Infection Model ◽  
Synergistic Activity ◽  
Bacterial Strains ◽  
Molecular Docking Study

Aim: The aim of the study was to find out the role of auranofin as a promising broad spectrum antibacterial agent. Methods: In-vitro assays (Percentage growth retardation, Bacterial growth kinetics, Biofilm formation assay) and In-silico study (Molegro virtual docker (MVD) version 6.0 and Molecular operating environment (MOE) version 2008.10 software). Results: The in vitro assays have shown that auranofin has good antibacterial activity against Gram positive and Gram negative bacterial strains. Further, auranofin has shown synergistic activity in combination with ampicillin against S. aureus and B. subtilis whereas in combination with neomycin has just shown additive effect against E. coli, P. aeruginosa and B. pumilus. In vivo results have revealed that auranofin alone and in combination with standard drugs significantly decreased the bioburden in zebrafish infection model as compared to control. The molecular docking study have shown good interaction of auranofin with penicillin binding protein (2Y2M), topoisomerase (3TTZ), UDP-3-O-[3- hydroxymyristoyl] N-acetylglucosaminedeacetylase (3UHM), cell adhesion protein (4QRK), β-lactamase (5CTN) and arylsulphatase (1HDH) enzyme as that of reference ligand which indicate multimodal mechanism of action of auranofin. Finally, MTT assay has shown non-cytotoxic effect of auranofin. Conclusion: In conclusion, auranofin in combination with existing antibiotics could be developed as a broad spectrum antibacterial agent; however, further studies are required to confirm its safety and efficacy. This study provides possibility of use of auranofin apart from its established therapeutic indication in combination with existing antibiotics to tackle the problem of resistance.

scholarly journals Porphyrin−Apidaecin Conjugate as a New Broad Spectrum Antibacterial Agent

2010 ◽  
Vol 1 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Ryan Dosselli ◽  
Marina Gobbo ◽  
Erika Bolognini ◽  
Sandro Campestrini ◽  
Elena Reddi
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent

scholarly journals Increasing antimicrobial resistance of Shigella isolates in Israel during the period 1984 to 1992.

1995 ◽  
Vol 39 (4) ◽  
pp. 819-823 ◽  
Author(s):  
S Ashkenazi ◽  
M May-Zahav ◽  
J Sulkes ◽  
R Zilberberg ◽  
Z Samra
Keyword(s):  
Antimicrobial Resistance ◽  
Nalidixic Acid ◽  
Broad Spectrum ◽  
Empiric Therapy ◽  
Shigella Sonnei ◽  
Shigella Spp ◽  
Stool Cultures

Recent (1984 to 1992) trends in the antimicrobial resistance of Shigella isolates in Israel were studied by analyzing the results of 106,000 stool cultures, 3,511 of which yielded Shigella spp. Over the study period, resistance to trimethoprim-sulfamethoxazole (TMP-SMX) increased from 59 to 92% (P = 0.0038) and that to ampicillin increased from 13 to 86% (P < 0.0001). Resistances to nalidixic acid, chloramphenicol, and broad-spectrum cephalosporins remained low. Shigella sonnei, which currently accounts for 90% of Shigella infections, was more resistant than S. flexneri to TMP-SMX (81 versus 57%, P < 10(-6)), ampicillin (42 versus 32%, P < 10(-5)), and tetracycline (38 versus 28%, P < 10(-5)). S. boydii and S. dysenteriae were relatively rare. Seasonality in antimicrobial resistance was found, with summer isolates being less resistant to TMP-SMX, ampicillin, or both than isolates obtained over the rest of the year (P < 10(-5)). We conclude that the resistance of shigellae, especially S. sonnei, to TMP-SMX and ampicillin is increasing to approximately 90%. Resistance should be recorded locally, and empiric therapy for suspected shigellosis should be changed accordingly.

scholarly journals NB2001, a Novel Antibacterial Agent with Broad-Spectrum Activity and Enhanced Potency against β-Lactamase-Producing Strains

2002 ◽  
Vol 46 (5) ◽  
pp. 1262-1268 ◽  
Author(s):  
Qing Li ◽  
Jean Y. Lee ◽  
Rosario Castillo ◽  
Mark S. Hixon ◽  
Catherine Pujol ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Bacterial Resistance ◽  
Enterobacter Aerogenes ◽  
Order Rate Constant ◽  
Common Mechanism ◽  
E Coli ◽  
Lactam Ring ◽  
Spectrum Activity ◽  
Hydrolysis Of

ABSTRACT Enzyme-catalyzed therapeutic activation (ECTA) is a novel prodrug strategy to overcome drug resistance resulting from enzyme overexpression. β-Lactamase overexpression is a common mechanism of bacterial resistance to β-lactam antibiotics. We present here the results for one of the β-lactamase ECTA compounds, NB2001, which consists of the antibacterial agent triclosan in a prodrug form with a cephalosporin scaffold. Unlike conventional β-lactam antibiotics, where hydrolysis of the β-lactam ring inactivates the antibiotic, hydrolysis of NB2001 by β-lactamase releases triclosan. Evidence supporting the proposed mechanism is as follows. (i) NB2001 is a substrate for TEM-1 β-lactamase, forming triclosan with a second-order rate constant (k cat/Km ) of greater than 77,000 M−1 s−1. (ii) Triclosan is detected in NB2001-treated, β-lactamase-producing Escherichia coli but not in E. coli that does not express β-lactamase. (iii) NB2001 activity against β-lactamase-producing E. coli is decreased in the presence of the β-lactamase inhibitor clavulanic acid. NB2001 was similar to or more potent than reference antibiotics against clinical isolates of Staphylococcus aureus (including MRSA), Staphylococcus epidermidis, Streptococcus pneumoniae, vancomycin-resistant Enterococcus faecalis, Moraxella catarrhalis and Haemophilus influenzae. NB2001 is also active against Klebsiella pneumoniae, Enterobacter aerogenes, and Enterobacter cloacae. The results indicate that NB2001 is a potent, broad-spectrum antibacterial agent and demonstrate the potential of ECTA in overcoming β-lactamase-mediated resistance.

Antibacterial Activity Inhibition after the Degradation of Flumequine by UV/H2O2

2011 ◽  
Vol 14 (1) ◽  
Author(s):  
Caio Rodrigues da Silva ◽  
Milena Guedes Maniero ◽  
Susanne Rath ◽  
José Roberto Guimarães
Keyword(s):  
Antibacterial Activity ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Veterinary Drug ◽  
Drug Resistant ◽  
Bacterial Strains ◽  
Activity Inhibition

AbstractFlumequine is a broad-spectrum antibacterial agent of the quinolone class widely used as veterinary drug in food-producing animals. It is considered as pseudo-persistent compound continuously introduced into the environment and its presence in the environment may contribute to the development of drug resistant bacterial strains. In this study antibacterial activity removal during flumequine degradation by UV/H

Prevalence and Antimicrobial Resistance of Salmonella Isolates Recovered from Retail Pork in Major Village Markets in Tai'an Region, China

2017 ◽  
Vol 80 (10) ◽  
pp. 1635-1640 ◽  
Author(s):  
Zengmin Miao ◽  
Song Li ◽  
Kun Qin ◽  
Yufa Zhou
Keyword(s):  
Antimicrobial Resistance ◽  
Broad Spectrum ◽  
Antimicrobial Susceptibility ◽  
Multilocus Sequence Typing ◽  
Susceptibility Testing ◽  
Antimicrobial Susceptibility Testing ◽  
Contamination Rate ◽  
Sequence Types ◽  
Pork Samples

ABSTRACT The current study was undertaken to evaluate Salmonella contamination in retail pork at major village markets of the Tai'an region, China. In total, 200 retail pork samples were collected from four village markets between June 2015 and February 2016, of which 69 samples (34.5%) were determined to be positive for Salmonella. Eleven serotypes were identified from the 69 Salmonella isolates, and Salmonella Derby was the most common (18 of 69, 26.1%), followed by Typhimurium (17 of 69, 24.6%) and Meleagridis (11 of 69, 15.9%). Antimicrobial susceptibility testing showed that antimicrobial resistance against tetracycline was the most prevalent (42 of 69, 60.9%), but antimicrobial resistance against both ceftriaxone and cefotaxime was 1.4% (1 of 69) and 2.9% (2 of 69), respectively. Multilocus sequence typing revealed that the 69 Salmonella isolates were divided into 11 sequence types (STs), among which ST40 (18 of 69, 26.1%) was the most common, followed by ST34 (15 of 69, 21.7%) and ST64 (13 of 69, 18.8%). Collectively, retail pork at village markets in the Tai'an region has a high Salmonella contamination rate, and these isolates exhibit broad-spectrum antimicrobial resistance. However, the absence of a dominant ST demonstrates that the Salmonella isolates from retail pork may be of diverse origins.

scholarly journals The challenge of recognising sepsis: Future nanotechnology solutions

2019 ◽  
Vol 21 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Andrew Claxton ◽  
Lana Papafilippou ◽  
Marilena Hadjidemetriou ◽  
Kostas Kostarelos ◽  
Paul Dark
Keyword(s):  
Antimicrobial Resistance ◽  
Broad Spectrum ◽  
Potential Role ◽  
Biomarker Discovery ◽  
High Sensitivity ◽  
Diagnostic Information ◽  
Therapeutic Interventions ◽  
Specific Time ◽  
Suspected Sepsis ◽  
Time Critical

The urgent need to start anti-infective therapeutic interventions in suspected sepsis, and the lack of specific time-critical diagnostic information often lead to the widespread administration of broad-spectrum antimicrobial therapies, increasing the risk of unwanted patient harms and contributing to rising pathogen antimicrobial resistance. Nanotechnology, which involves engineering at the nanoscale, allows for the bespoke development of diagnostic solutions with multi-functionality and high sensitivity that has the potential to help provide time-critical information to make more accurate diagnoses and treatment decisions for sepsis. Nanotechnologies also have the potential to improve upon the current strategies used for novel biomarker discovery. Here we describe some of the current limitations to identifying sepsis and explore the potential role for nanotechnology solutions.

Facile synthesis of monodisperse chromogenic amylose–iodine nanoparticles as an efficient broad-spectrum antibacterial agent

2020 ◽  
Vol 8 (15) ◽  
pp. 3010-3015
Author(s):  
Yanbin Sun ◽  
Xianwen Wang ◽  
Linxin Fan ◽  
Xianli Xie ◽  
Zhaohua Miao ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Near Infrared ◽  
Infrared Laser ◽  
Facile Synthesis ◽  
Infrared Laser Irradiation

Monodisperse chromogenic amylose–iodine nanoparticles were developed as an efficient broad-spectrum antibacterial agent under the assistance of near-infrared laser irradiation.

scholarly journals Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0183457 ◽  
Author(s):  
Abiodun D. Ogunniyi ◽  
Manouchehr Khazandi ◽  
Andrew J. Stevens ◽  
Sarah K. Sims ◽  
Stephen W. Page ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent

Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance

2015 ◽  
Vol 96 ◽  
pp. 152-161 ◽  
Author(s):  
M.S. Nieto-Bobadilla ◽  
F. Siepmann ◽  
M. Djouina ◽  
L. Dubuquoy ◽  
N. Tesse ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Controlled Delivery
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