Design, synthesis, and biological evaluation of thieno[3,2‐d]pyrimidine derivatives as potential simplified phosphatidylinositol 3‐kinase alpha inhibitors

2019 ◽  
Vol 94 (6) ◽  
pp. 2013-2022
Author(s):  
Xiuyan Yang ◽  
Meng Deng ◽  
Xi Zhang ◽  
Yi Wang ◽  
Kun Song ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Phosphatidylinositol 3 Kinase ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Phosphatidylinositol 3

Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation

2020 ◽  
Vol 206 ◽  
pp. 112691
Author(s):  
Naga Rajiv Lakkaniga ◽  
Naresh Gunaganti ◽  
Lingtian Zhang ◽  
Binyam Belachew ◽  
Brendan Frett ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of aryl pyrimidine derivatives as potential leishmanicidal agents

2013 ◽  
Vol 23 (18) ◽  
pp. 5235-5238 ◽  
Author(s):  
S.N. Suryawanshi ◽  
Santosh Kumar ◽  
Rahul Shivahare ◽  
Susmita Pandey ◽  
Avinash Tiwari ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-c]quinazoline derivatives as novel phosphatidylinositol 3-kinase and histone deacetylase dual inhibitors

RSC Advances ◽  
2017 ◽  
Vol 7 (82) ◽  
pp. 52180-52186 ◽  
Author(s):  
Yichao Wu ◽  
Weichen Dai ◽  
Xin Chen ◽  
Aixin Geng ◽  
Yadong Chen ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Inhibitory Activity ◽  
Biological Evaluation ◽  
Design Approach ◽  
Phosphatidylinositol 3 Kinase ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Quinazoline Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Novel Design

A novel design approach by combination of PI3K and HDAC inhibitory activity in one molecule to produce dual inhibitors.

Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

2019 ◽  
Vol 27 (8) ◽  
pp. 1529-1545 ◽  
Author(s):  
Anna C. Giddens ◽  
Swarna A. Gamage ◽  
Jackie D. Kendall ◽  
Woo-Jeong Lee ◽  
Bruce C. Baguley ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Biological Evaluation ◽  
Phosphatidylinositol 3 Kinase ◽  
Synthesis And Biological Evaluation ◽  
Phosphatidylinositol 3

ChemInform Abstract: Design, Synthesis and Biological Evaluation of Aryl Pyrimidine Derivatives as Potential Leishmanicidal Agents.

ChemInform ◽  
2014 ◽  
Vol 45 (4) ◽  
pp. no-no
Author(s):  
S. N. Suryawanshi ◽  
Santosh Kumar ◽  
Rahul Shivahare ◽  
Susmita Pandey ◽  
Avinash Tiwari ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis, and biological evaluation of new thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents

MedChemComm ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1655-1658 ◽  
Author(s):  
Zhong-Hua Li ◽  
Xue-Qi Liu ◽  
Peng-Fei Geng ◽  
Jin-Lian Ma ◽  
Tao-Qian Zhao ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivative ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Potent Inhibition ◽  
Synthesis And Biological Evaluation

The thiazolo[5,4-d]pyrimidine derivative 7i exhibited potent inhibition against MGC-803 and HGC-27 with IC50 values of 4.64 and 5.07 μM, respectively and around 12-fold selectivity between MGC-803 and GES-1.

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