Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

2011 ◽  
Vol 54 (14) ◽  
pp. 4998-5012 ◽  
Author(s):  
Kazuhiro Miwa ◽  
Takenori Hitaka ◽  
Takashi Imada ◽  
Satoshi Sasaki ◽  
Mie Yoshimatsu ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Peptide Antagonist ◽  
Gonadotropin Releasing Hormone Receptor ◽  
Orally Active

scholarly journals Androgen Receptor Positively Regulates Gonadotropin-releasing Hormone Receptor in Pituitary Gonadotropes

2021 ◽  
pp. 111286
Author(s):  
Genevieve E. Ryan ◽  
Stephanie C. Bohaczuk ◽  
Jessica Cassin ◽  
Emily A. Witham ◽  
Shadi Shojaei ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Hormone Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Receptor

scholarly journals Proper receptor signalling in a mutant catfish gonadotropin-releasing hormone receptor lacking the highly conserved Asp90 residue

FEBS Letters ◽  
2001 ◽  
Vol 501 (2-3) ◽  
pp. 131-134 ◽  
Author(s):  
Marion Blomenröhr ◽  
Ronald Kühne ◽  
Eveline Hund ◽  
Rob Leurs ◽  
Jan Bogerd ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Receptor Signalling ◽  
Gonadotropin Releasing Hormone Receptor
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