Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPARγ-Selective Agonists: Discovery of Reversed Stereochemistry−Activity Relationship

Masao Ohashi; Takuji Oyama; Izumi Nakagome; Mayumi Satoh; Yoshino Nishio; Hiromi Nobusada; Shuichi Hirono; Kosuke Morikawa; Yuichi Hashimoto; Hiroyuki Miyachi

doi:10.1021/jm101233f

Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPARγ-Selective Agonists: Discovery of Reversed Stereochemistry−Activity Relationship

Journal of Medicinal Chemistry ◽

10.1021/jm101233f ◽

2011 ◽

Vol 54 (1) ◽

pp. 331-341 ◽

Cited By ~ 14

Author(s):

Masao Ohashi ◽

Takuji Oyama ◽

Izumi Nakagome ◽

Mayumi Satoh ◽

Yoshino Nishio ◽

...

Keyword(s):

Structural Analysis ◽

Activity Relationship ◽

Design Synthesis ◽

Acid Type ◽

Selective Agonists

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Design, synthesis, and structure–activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptor β (TRβ) selective agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.12.002 ◽

2013 ◽

Vol 21 (3) ◽

pp. 592-607 ◽

Cited By ~ 5

Author(s):

Hiroaki Shiohara ◽

Tetsuya Nakamura ◽

Norihiko Kikuchi ◽

Tomonaga Ozawa ◽

Akane Matsuzawa ◽

...

Keyword(s):

Thyroid Hormone ◽

Hormone Receptor ◽

Thyroid Hormone Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Selective Agonists ◽

Thyroid Hormone Receptor Β

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Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure–activity relationship for anti-inflammatory drug

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.01.053 ◽

2012 ◽

Vol 50 ◽

pp. 179-195 ◽

Cited By ~ 25

Author(s):

Shigeo Hayashi ◽

Naomi Ueno ◽

Akio Murase ◽

Yoko Nakagawa ◽

Junji Takada

Keyword(s):

Structure Activity Relationship ◽

Cyclooxygenase 2 ◽

Activity Relationship ◽

Design Synthesis ◽

Inflammatory Drug ◽

Structure Activity ◽

Acid Type ◽

Anti Inflammatory ◽

Cyclooxygenase 2 Inhibitors

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Design, synthesis, and structure–activity relationship of novel opioid κ receptor selective agonists: α-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2014.09.029 ◽

2014 ◽

Vol 24 (21) ◽

pp. 4980-4983 ◽

Cited By ~ 3

Author(s):

Yoshikazu Watanabe ◽

Shota Kitazawa ◽

Hideaki Fujii ◽

Toru Nemoto ◽

Shigeto Hirayama ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Selective Agonists ◽

Relationship Of ◽

Κ Receptor

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Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors

Medicinal Chemistry ◽

10.2174/1573406412666151109113007 ◽

2016 ◽

Vol 12 (4) ◽

pp. 338-346 ◽

Cited By ~ 2

Author(s):

Yan Xia ◽

Qiong Duan ◽

Bao-Hua Zhao ◽

Dong-Feng Li ◽

Rui-Bin Hou

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity

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Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113291 ◽

2021 ◽

pp. 113291

Author(s):

Peng Li ◽

Ying Liu ◽

Hua Yang ◽

Hong-Min Liu

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites

ACS Infectious Diseases ◽

10.1021/acsinfecdis.1c00092 ◽

2021 ◽

Author(s):

Palak Babbar ◽

Pronay Das ◽

Yogavel Manickam ◽

Yash Mankad ◽

Swati Yadav ◽

...

Keyword(s):

Structural Analysis ◽

Malaria Parasites ◽

Design Synthesis

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New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104704 ◽

2021 ◽

Vol 109 ◽

pp. 104704

Author(s):

Ismail M.M. Othman ◽

Mohamed A.M. Gad-Elkareem ◽

El Hassane Anouar ◽

Kaïss Aouadi ◽

Mejdi Snoussi ◽

...

Keyword(s):

Molecular Docking ◽

Structure Activity Relationship ◽

Trna Synthetase ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Sar Analysis

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Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor

MedChemComm ◽

10.1039/c3md00079f ◽

2013 ◽

Vol 4 (9) ◽

pp. 1267 ◽

Cited By ~ 16

Author(s):

Yulin Tian ◽

Jing Jin ◽

Xiaojian Wang ◽

Weijuan Han ◽

Gang Li ◽

...

Keyword(s):

3D Qsar ◽

Qsar Study ◽

Design Synthesis ◽

S1p1 Receptor ◽

Sphingosine 1 Phosphate ◽

Selective Agonists

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ChemInform Abstract: Design, Synthesis, and StructureâActivity Relationship of Novel Orally Efficacious Pyrazole/Sulfonamide Based Dihydroquinoline Î³-Secretase Inhibitors.

ChemInform ◽

10.1002/chin.201003214 ◽

2010 ◽

Vol 41 (3) ◽

Author(s):

Gary D. Probst ◽

et al. et al.

Keyword(s):

Activity Relationship ◽

Design Synthesis ◽

Relationship Of

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Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

Journal of Medicinal Chemistry ◽

10.1021/jm980410m ◽

1998 ◽

Vol 41 (24) ◽

pp. 4819-4832 ◽

Cited By ~ 183

Author(s):

Simon Feldbæk Nielsen ◽

Søren Brøgger Christensen ◽

Gabriele Cruciani ◽

Arsalan Kharazmi ◽

Tommy Liljefors

Keyword(s):

Three Dimensional ◽

Statistical Design ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity

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Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPARγ-Selective Agonists: Discovery of Reversed Stereochemistry−Activity Relationship

Design, synthesis, and structure–activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptor β (TRβ) selective agonists

Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure–activity relationship for anti-inflammatory drug

Design, synthesis, and structure–activity relationship of novel opioid κ receptor selective agonists: α-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton

Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors

Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites

New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis

Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor

ChemInform Abstract: Design, Synthesis, and StructureâActivity Relationship of Novel Orally Efficacious Pyrazole/Sulfonamide Based Dihydroquinoline Î³-Secretase Inhibitors.

Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

ChemInform Abstract: Design, Synthesis, and StructureâActivity Relationship of Novel Orally Efficacious Pyrazole/Sulfonamide Based Dihydroquinoline Î³-Secretase Inhibitors.