Biological and Conformational Evaluation of Bifunctional Compounds for Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists Possessing Two Penicillamines

Takashi Yamamoto; Padma Nair; Neil E. Jacobsen; Vinod Kulkarni; Peg Davis; Shou-wu Ma; Edita Navratilova; Henry I. Yamamura; Todd W. Vanderah; Frank Porreca; Josephine Lai; Victor J. Hruby

doi:10.1021/jm100157m

Biological and Conformational Evaluation of Bifunctional Compounds for Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists Possessing Two Penicillamines

Journal of Medicinal Chemistry ◽

10.1021/jm100157m ◽

2010 ◽

Vol 53 (15) ◽

pp. 5491-5501 ◽

Cited By ~ 14

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Neil E. Jacobsen ◽

Vinod Kulkarni ◽

Peg Davis ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Antagonists ◽

Neurokinin 1 Receptor ◽

Receptor Agonists ◽

Bifunctional Compounds ◽

Neurokinin 1 ◽

Opioid Receptor Agonists

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The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.08.035 ◽

2009 ◽

Vol 17 (20) ◽

pp. 7337-7343 ◽

Cited By ~ 20

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Shou-wu Ma ◽

Peg Davis ◽

Henry I. Yamamura ◽

...

Keyword(s):

Biological Activity ◽

Opioid Receptor ◽

Metabolic Stability ◽

Receptor Antagonists ◽

Neurokinin 1 Receptor ◽

Receptor Agonists ◽

Bifunctional Compounds ◽

Neurokinin 1 ◽

Opioid Receptor Agonists

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Improving Metabolic Stability by Glycosylation: Bifunctional Peptide Derivatives That Are Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm900473p ◽

2009 ◽

Vol 52 (16) ◽

pp. 5164-5175 ◽

Cited By ~ 33

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Neil E. Jacobsen ◽

Josef Vagner ◽

Vinod Kulkarni ◽

...

Keyword(s):

Opioid Receptor ◽

Metabolic Stability ◽

Receptor Antagonists ◽

Neurokinin 1 Receptor ◽

Receptor Agonists ◽

Peptide Derivatives ◽

Neurokinin 1 ◽

Opioid Receptor Agonists

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The Importance of Micelle-Bound States for the Bioactivities of Bifunctional Peptide Derivatives for δ/μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm800389v ◽

2008 ◽

Vol 51 (20) ◽

pp. 6334-6347 ◽

Cited By ~ 23

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Neil E. Jacobsen ◽

Peg Davis ◽

Shou-wu Ma ◽

...

Keyword(s):

Opioid Receptor ◽

Bound States ◽

Receptor Antagonists ◽

Neurokinin 1 Receptor ◽

Receptor Agonists ◽

Peptide Derivatives ◽

Μ Opioid Receptor ◽

Neurokinin 1 ◽

Opioid Receptor Agonists

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Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm061369n ◽

2007 ◽

Vol 50 (12) ◽

pp. 2779-2786 ◽

Cited By ~ 40

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Peg Davis ◽

Shou-wu Ma ◽

Edita Navratilova ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Neurokinin 1 Receptor ◽

Modified Peptides ◽

Μ Opioid Receptor ◽

Neurokinin 1 ◽

Opioid Receptor Agonists ◽

Synthesis And Biological Evaluation

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Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats

Journal of Pharmacological Sciences ◽

10.1254/jphs.scj05006x ◽

2006 ◽

Vol 100 (2) ◽

pp. 157-161 ◽

Cited By ~ 14

Author(s):

Tomohisa Mori ◽

Mutsuko Nomura ◽

Kazumi Yoshizawa ◽

Hiroshi Nagase ◽

Toshiko Sawaguchi ◽

...

Keyword(s):

Nmda Receptor ◽

Opioid Receptor ◽

Discriminative Stimulus ◽

Nmda Receptor Antagonists ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Discriminative Stimulus Effects ◽

Stimulus Effects ◽

Opioid Receptor Agonists

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Transformation of μ-opioid receptor agonists into biologically potent μ-opioid receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.11.019 ◽

2007 ◽

Vol 15 (3) ◽

pp. 1237-1251 ◽

Cited By ~ 11

Author(s):

Tingyou Li ◽

Yunden Jinsmaa ◽

Masahiro Nedachi ◽

Anna Miyazaki ◽

Yuko Tsuda ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Opioid Receptor Antagonists ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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A Structure–Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are δ/μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm070332f ◽

2008 ◽

Vol 51 (5) ◽

pp. 1369-1376 ◽

Cited By ~ 36

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Josef Vagner ◽

Tally Largent-Milnes ◽

Peg Davis ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Synthetic Approach ◽

Neurokinin 1 Receptor ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Relationship Study ◽

Neurokinin 1 ◽

Opioid Receptor Agonists

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Design and Synthesis of Novel Hydrazide-Linked Bifunctional Peptides as δ/μ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm050851n ◽

2006 ◽

Vol 49 (5) ◽

pp. 1773-1780 ◽

Cited By ~ 25

Author(s):

Yeon Sun Lee ◽

Richard S. Agnes ◽

Hamid Badghisi ◽

Peg Davis ◽

Shou-wu Ma ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Design And Synthesis ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112144 ◽

2020 ◽

Vol 191 ◽

pp. 112144 ◽

Cited By ~ 3

Author(s):

Jiaying Xiong ◽

Jian Jin ◽

Lanchang Gao ◽

Chao Hao ◽

Xin Liu ◽

...

Keyword(s):

Neuropathic Pain ◽

Opioid Receptor ◽

Mu Opioid Receptor ◽

Receptor Antagonists ◽

Sigma 1 Receptor ◽

Mu Opioid ◽

Receptor Agonists ◽

Sigma 1 ◽

Opioid Receptor Agonists

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Effects of NMDA receptor antagonists on δ1- and δ2-opioid receptor agonists-induced changes in the mouse brain []DPDPE binding

European Journal of Pharmacology ◽

10.1016/s0014-2999(97)01216-8 ◽

1997 ◽

Vol 335 (2-3) ◽

pp. 161-166 ◽

Cited By ~ 4

Author(s):

Ying-Jun Cao ◽

Jing-Tan Bian ◽

Hemendra N Bhargava

Keyword(s):

Nmda Receptor ◽

Opioid Receptor ◽

Mouse Brain ◽

Nmda Receptor Antagonists ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Induced Changes ◽

Opioid Receptor Agonists

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