Structure–Activity Relationships of Cyclic Lactam Analogues of α-Melanocyte-Stimulating Hormone (α-MSH) Targeting the Human Melanocortin-3 Receptor

Alexander V. Mayorov; Minying Cai; Erin S. Palmer; Matthew M. Dedek; James P. Cain; April R. Van Scoy; Bahar Tan; Josef Vagner; Dev Trivedi; Victor J. Hruby

doi:10.1021/jm070461w

Structure–Activity Relationships of Cyclic Lactam Analogues of α-Melanocyte-Stimulating Hormone (α-MSH) Targeting the Human Melanocortin-3 Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm070461w ◽

2008 ◽

Vol 51 (2) ◽

pp. 187-195 ◽

Cited By ~ 8

Author(s):

Alexander V. Mayorov ◽

Minying Cai ◽

Erin S. Palmer ◽

Matthew M. Dedek ◽

James P. Cain ◽

...

Keyword(s):

Structure Activity Relationships ◽

Melanocyte Stimulating Hormone ◽

Structure Activity ◽

Cyclic Lactam ◽

Stimulating Hormone

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The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone: Structure-Activity Relationships for Melanotropins at Melanocortin Receptors

Melanocortin Receptors, The ◽

10.1385/1-59259-031-4:239 ◽

2003 ◽

pp. 239-261 ◽

Cited By ~ 2

Author(s):

Victor J. Hruby ◽

Guoxia Han

Keyword(s):

Melanocortin Receptors ◽

Molecular Pharmacology ◽

Structure Activity Relationships ◽

Melanocyte Stimulating Hormone ◽

Structure Activity ◽

Stimulating Hormone

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Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure–Activity Relationships at the Mouse Melanocortin Receptors

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.6b00098 ◽

2016 ◽

Vol 7 (7) ◽

pp. 984-994 ◽

Cited By ~ 3

Author(s):

Aleksandar Todorovic ◽

Mark D. Ericson ◽

Ryan D. Palusak ◽

Nicholas B. Sorensen ◽

Michael S. Wood ◽

...

Keyword(s):

Melanocortin Receptors ◽

Structure Activity Relationships ◽

Melanocyte Stimulating Hormone ◽

Differential Structure ◽

Structure Activity ◽

Positional Scanning ◽

Stimulating Hormone

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?-Melanocyte-stimulating hormone structure-activity studies: Comparative analysis of melanotropic and CNS bioactivities

Synapse ◽

10.1002/syn.890020318 ◽

1988 ◽

Vol 2 (3) ◽

pp. 288-292 ◽

Cited By ~ 4

Author(s):

Tomi K. Sawyer ◽

Mac E. Hadley ◽

Victor J. Hruby ◽

Ana Maria de Lauro Castrucci ◽

Douglas J. Staples ◽

...

Keyword(s):

Comparative Analysis ◽

Melanocyte Stimulating Hormone ◽

Structure Activity ◽

Stimulating Hormone

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Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors

Peptides ◽

10.1016/j.peptides.2010.06.026 ◽

2010 ◽

Vol 31 (10) ◽

pp. 1894-1905 ◽

Cited By ~ 7

Author(s):

Alexander V. Mayorov ◽

Minying Cai ◽

Erin S. Palmer ◽

Zhihua Liu ◽

James P. Cain ◽

...

Keyword(s):

Solid Phase ◽

Side Chain ◽

Melanocortin Receptors ◽

Signaling Protein ◽

Melanocyte Stimulating Hormone ◽

Cyclic Lactam ◽

Stimulating Hormone

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Evaluation of Small-Molecule Modulators of the Luteinizing Hormone/Choriogonadotropin and Thyroid Stimulating Hormone Receptors: Structure−Activity Relationships and Selective Binding Patterns

Journal of Medicinal Chemistry ◽

10.1021/jm060247s ◽

2006 ◽

Vol 49 (13) ◽

pp. 3888-3896 ◽

Cited By ~ 58

Author(s):

Susanna Moore ◽

Holger Jaeschke ◽

Gunnar Kleinau ◽

Susanne Neumann ◽

Stefano Costanzi ◽

...

Keyword(s):

Luteinizing Hormone ◽

Small Molecule ◽

Hormone Receptors ◽

Thyroid Stimulating Hormone ◽

Selective Binding ◽

Structure Activity Relationships ◽

Structure Activity ◽

Small Molecule Modulators ◽

Stimulating Hormone

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Periodate oxidation, acid hydrolysis, and structure-activity relationships of human-pituitary, follicle-stimulating hormone and human chorionic gonadotrophin

Carbohydrate Research ◽

10.1016/s0008-6215(00)83058-x ◽

1974 ◽

Vol 36 (2) ◽

pp. 369-377 ◽

Cited By ~ 1

Author(s):

John F. Kennedy ◽

Martin F. Chaplin ◽

Maurice Stacey

Keyword(s):

Acid Hydrolysis ◽

Follicle Stimulating Hormone ◽

Periodate Oxidation ◽

Chorionic Gonadotrophin ◽

Human Chorionic Gonadotrophin ◽

Human Pituitary ◽

Structure Activity Relationships ◽

Structure Activity ◽

Stimulating Hormone

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α-Melanocyte stimulating hormone message and inhibitory sequences: Comparative structure-activity studies on melanocytes

Peptides ◽

10.1016/0196-9781(90)90092-j ◽

1990 ◽

Vol 11 (2) ◽

pp. 351-357 ◽

Cited By ~ 31

Author(s):

Tomi K. Sawyer ◽

Douglas J. Staples ◽

Ana M.L. Castrucci ◽

Mac E. Hadley ◽

Fahad A. Al-Obeidi ◽

...

Keyword(s):

Melanocyte Stimulating Hormone ◽

Structure Activity ◽

Comparative Structure ◽

Stimulating Hormone

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Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

Journal of Medicinal Chemistry ◽

10.1021/jm00018a005 ◽

1995 ◽

Vol 38 (18) ◽

pp. 3454-3461 ◽

Cited By ~ 256

Author(s):

Victor J. Hrubu ◽

Dongsi Lu ◽

Shubh D. Sharma ◽

Ana de L. Castrucci ◽

Robert A. Kesterson ◽

...

Keyword(s):

Amino Acids ◽

Aromatic Amino Acids ◽

Melanocortin Receptors ◽

Melanocyte Stimulating Hormone ◽

Cyclic Lactam ◽

Stimulating Hormone

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Effects of Macrocycle Size and Rigidity on Melanocortin Receptor-1 and -5 Selectivity in Cyclic Lactam alpha-Melanocyte-Stimulating Hormone Analogs

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2006.00383.x ◽

2006 ◽

Vol 67 (5) ◽

pp. 329-335 ◽

Cited By ~ 13

Author(s):

Alexander V. Mayorov ◽

So-Yeop Han ◽

Minying Cai ◽

Matthew R. Hammer ◽

Dev Trivedi ◽

...

Keyword(s):

Melanocortin Receptor ◽

Melanocyte Stimulating Hormone ◽

Hormone Analogs ◽

Cyclic Lactam ◽

Stimulating Hormone

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Structure-Activity Relationships of MDMA-Like Substances

PsycEXTRA Dataset ◽

10.1037/e496472006-001 ◽

1989 ◽

Cited By ~ 3

Author(s):

David E. Nichols ◽

◽

Robert Oberlender

Keyword(s):

Structure Activity Relationships ◽

Structure Activity

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