Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

1995 ◽  
Vol 38 (18) ◽  
pp. 3454-3461 ◽  
Author(s):  
Victor J. Hrubu ◽  
Dongsi Lu ◽  
Shubh D. Sharma ◽  
Ana de L. Castrucci ◽  
Robert A. Kesterson ◽  
...  
Keyword(s):  
Amino Acids ◽  
Aromatic Amino Acids ◽  
Melanocortin Receptors ◽  
Melanocyte Stimulating Hormone ◽  
Cyclic Lactam ◽  
Stimulating Hormone

scholarly journals Contribution of the Conserved Amino Acids of the Melanocortin-4 Receptor in d-[Nle4,Phe7]-α-Melanocyte-stimulating Hormone Binding and Signaling

2007 ◽  
Vol 282 (30) ◽  
pp. 21712-21719 ◽  
Author(s):  
Min Chen ◽  
Minying Cai ◽  
Charles J. Aprahamian ◽  
Keith E. Georgeson ◽  
Victor Hruby ◽  
...  
Keyword(s):  
Amino Acids ◽  
Hormone Binding ◽  
Melanocyte Stimulating Hormone ◽  
Melanocortin 4 Receptor ◽  
Conserved Amino Acids ◽  
Stimulating Hormone
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