Substitutedtrans-Stilbenes, Including Analogues of the Natural Product Resveratrol, Inhibit the Human Tumor Necrosis Factor Alpha-Induced Activation of Transcription Factor Nuclear Factor KappaB

2006 ◽  
Vol 49 (24) ◽  
pp. 7182-7189 ◽  
Author(s):  
Justin J. Heynekamp ◽  
Waylon M. Weber ◽  
Lucy A. Hunsaker ◽  
Amanda M. Gonzales ◽  
Robert A. Orlando ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Human Tumor ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor Alpha ◽  
Activation Of Transcription ◽  
Factor Alpha ◽  
Transcription Factor Nuclear Factor ◽  
Necrosis Factor

scholarly journals PEGylated Recombinant Human Tumor Necrosis Factor Alpha: Pharmacokinetics and Anti-tumor Effects.

2001 ◽  
Vol 24 (6) ◽  
pp. 666-670 ◽  
Author(s):  
Ya-Ping LI ◽  
Yuan-Ying PEI ◽  
Zhao-Hui ZHOU ◽  
Xian-Ying ZHANG ◽  
Zhou-Hui GU ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

The Role of Nuclear Factor-kappaB and Melanogenesis in Tumor Necrosis Factor-Alpha-Induced Apoptosis of Normal Human Melanocytes

2002 ◽  
Vol 15 (5) ◽  
pp. 321-329 ◽  
Author(s):  
Jing Shang ◽  
Jürgen Eberle ◽  
Christoph C. Geilen ◽  
Amir M. Hossini ◽  
Lothar F. Fecker ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Necrosis Factor Alpha ◽  
Human Melanocytes ◽  
Normal Human ◽  
Factor Alpha ◽  
Induced Apoptosis ◽  
Necrosis Factor

scholarly journals Enhancement of release from MHC class II antigen-positive monocytes of hematopoietic colony stimulating factors CSF-1 and G-CSF by recombinant human tumor necrosis factor-alpha: synergism with recombinant human interferon-gamma

Blood ◽  
1988 ◽  
Vol 72 (1) ◽  
pp. 34-41 ◽  
Author(s):  
L Lu ◽  
D Walker ◽  
CD Graham ◽  
A Waheed ◽  
RK Shadduck ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Human Interferon ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor Alpha ◽  
Hla Dr ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Recombinant Human Interferon Gamma

Abstract The influence of purified recombinant human tumor necrosis factor-alpha (rhuTNF-alpha) was assessed alone and in combination with purified recombinant human interferon gamma (rhuIFN-gamma) for its effects on enhancing release from human monocytes of activities that stimulate colony formation by granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM) progenitor cells. RhuTNF-alpha or rhuIFN- gamma enhanced release of colony stimulating factors (CSFs), which were determined by a combination of human and mouse colony assays, morphological assessment of colony types and neutralization studies with anti-human macrophage CSF (CSF-1) and anti-human granulocyte (G)- CSF to be CSF-1 and G-CSF. The activity in the uninduced and induced monocyte conditioned media (CM) for CFU-GM-type colonies and clusters was attributed to the presence of both CSF-1 and G-CSF, while the activity in the monocyte CM for BFU-E and CFU-GEMM colonies was attributed to the presence of G-CSF. Monocytes were separated by two- color fluorescence using a dye laser flow cytometry system with cells labeled with anti-leu M3 conjugated with fluorescein isothiocyanate and anti-HLA-DR conjugated with phycoerythrin. While “constitutive” release of CSFs from monocytes was apparent from both the leu M3+, HLA-DR+ and the leu M3+, HLA-DR- (low density or negative DR) fractions, enhanced release of CSFs in response to rhuTNF-alpha or rhuIFN-gamma was confined to the leu M3+, HLA-DR+ population of cells. RhuTNF-alpha and rhuIFN-gamma synergized to enhance release of CSFs such that low concentrations of each molecule, which were inactive when used alone, were active when the two molecules were used together. These studies suggest a role, at least in vitro, for TNF-alpha and IFN-gamma in the release of CSFs from cells of the mononuclear phagocytic lineage.

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