Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.

2000 ◽  
Author(s):  
M Sasaki ◽  
K Nakajima ◽  
G Perinchery ◽  
T Fujino ◽  
B R Oh ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Tumor Necrosis Factor ◽  
Promoter Region ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor Alpha ◽  
Uterine Endometrial Cancer ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals PEGylated Recombinant Human Tumor Necrosis Factor Alpha: Pharmacokinetics and Anti-tumor Effects.

2001 ◽  
Vol 24 (6) ◽  
pp. 666-670 ◽  
Author(s):  
Ya-Ping LI ◽  
Yuan-Ying PEI ◽  
Zhao-Hui ZHOU ◽  
Xian-Ying ZHANG ◽  
Zhou-Hui GU ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Enhancement of release from MHC class II antigen-positive monocytes of hematopoietic colony stimulating factors CSF-1 and G-CSF by recombinant human tumor necrosis factor-alpha: synergism with recombinant human interferon-gamma

Blood ◽  
1988 ◽  
Vol 72 (1) ◽  
pp. 34-41 ◽  
Author(s):  
L Lu ◽  
D Walker ◽  
CD Graham ◽  
A Waheed ◽  
RK Shadduck ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Human Interferon ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor Alpha ◽  
Hla Dr ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Recombinant Human Interferon Gamma

Abstract The influence of purified recombinant human tumor necrosis factor-alpha (rhuTNF-alpha) was assessed alone and in combination with purified recombinant human interferon gamma (rhuIFN-gamma) for its effects on enhancing release from human monocytes of activities that stimulate colony formation by granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM) progenitor cells. RhuTNF-alpha or rhuIFN- gamma enhanced release of colony stimulating factors (CSFs), which were determined by a combination of human and mouse colony assays, morphological assessment of colony types and neutralization studies with anti-human macrophage CSF (CSF-1) and anti-human granulocyte (G)- CSF to be CSF-1 and G-CSF. The activity in the uninduced and induced monocyte conditioned media (CM) for CFU-GM-type colonies and clusters was attributed to the presence of both CSF-1 and G-CSF, while the activity in the monocyte CM for BFU-E and CFU-GEMM colonies was attributed to the presence of G-CSF. Monocytes were separated by two- color fluorescence using a dye laser flow cytometry system with cells labeled with anti-leu M3 conjugated with fluorescein isothiocyanate and anti-HLA-DR conjugated with phycoerythrin. While “constitutive” release of CSFs from monocytes was apparent from both the leu M3+, HLA-DR+ and the leu M3+, HLA-DR- (low density or negative DR) fractions, enhanced release of CSFs in response to rhuTNF-alpha or rhuIFN-gamma was confined to the leu M3+, HLA-DR+ population of cells. RhuTNF-alpha and rhuIFN-gamma synergized to enhance release of CSFs such that low concentrations of each molecule, which were inactive when used alone, were active when the two molecules were used together. These studies suggest a role, at least in vitro, for TNF-alpha and IFN-gamma in the release of CSFs from cells of the mononuclear phagocytic lineage.

scholarly journals FN3 protein fragment containing two type III fibronectin domains from B. longum GT15 binds to human tumor necrosis factor alpha in vitro

Anaerobe ◽  
2020 ◽  
Vol 65 ◽  
pp. 102247 ◽  
Author(s):  
Ilya N. Dyakov ◽  
Dilara A. Mavletova ◽  
Irina N. Chernyshova ◽  
Nadezda A. Snegireva ◽  
Marina V. Gavrilova ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Human Tumor Necrosis Factor ◽  
Protein Fragment ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Fibronectin Domains ◽  
Necrosis Factor
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