Synthesis and Structure−Activity Relationships of Pyrazine-Pyridine Biheteroaryls as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors

Gee-Hong Kuo; Catherine Prouty; Aihua Wang; Stuart Emanuel; Alan DeAngelis; Yan Zhang; Fengbin Song; Lawrence Beall; Peter J. Connolly; Prahba Karnachi; Xin Chen; Robert H. Gruninger; Jan Sechler; Angel Fuentes-Pesquera; Steven A. Middleton; Linda Jolliffe; William V. Murray

doi:10.1021/jm058205b

Synthesis and Structure−Activity Relationships of Pyrazine-Pyridine Biheteroaryls as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm058205b ◽

2005 ◽

Vol 48 (15) ◽

pp. 4892-4909 ◽

Cited By ~ 23

Author(s):

Gee-Hong Kuo ◽

Catherine Prouty ◽

Aihua Wang ◽

Stuart Emanuel ◽

Alan DeAngelis ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelial Growth Factor

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Synthesis and Structure–Activity Relationships of (Aryloxy)quinazoline Ureas as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm2013453 ◽

2012 ◽

Vol 55 (3) ◽

pp. 1189-1204 ◽

Cited By ~ 44

Author(s):

Antonio Garofalo ◽

Amaury Farce ◽

Séverine Ravez ◽

Amélie Lemoine ◽

Perrine Six ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelial Growth Factor

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Structure–activity relationship studies of indolin‐2‐one derivatives as vascular endothelial growth factor receptor inhibitors and anticancer agents

Archiv der Pharmazie ◽

10.1002/ardp.202000022 ◽

2020 ◽

Vol 353 (12) ◽

pp. 2000022

Author(s):

Mozhdeh Yousefian ◽

Razieh Ghodsi

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Anticancer Agents ◽

Growth Factor Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Vascular Endothelial ◽

Structure Activity ◽

Endothelial Growth Factor

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Synthesis and Structure−Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Inhibitors of the Fibroblast Growth Factor Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinases

Journal of Medicinal Chemistry ◽

10.1021/jm0500931 ◽

2005 ◽

Vol 48 (14) ◽

pp. 4628-4653 ◽

Cited By ~ 35

Author(s):

Andrew M. Thompson ◽

Amy M. Delaney ◽

James M. Hamby ◽

Mel C. Schroeder ◽

Teresa A. Spoon ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Structure Activity ◽

Dual Inhibitors ◽

Endothelial Growth Factor

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Quantitative Structure-Activity Relationship and Classification Analysis of Diaryl Ureas Against Vascular Endothelial Growth Factor Receptor-2 Kinase Using Linear and Non-Linear Models

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2009.00814.x ◽

2009 ◽

Vol 73 (6) ◽

pp. 644-654 ◽

Cited By ~ 11

Author(s):

Min Sun ◽

Junqing Chen ◽

Hongtao Wei ◽

Shuangqing Yin ◽

Yan Yang ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Linear Models ◽

Growth Factor Receptor ◽

Quantitative Structure Activity Relationship ◽

Vascular Endothelial ◽

Quantitative Structure ◽

Classification Analysis ◽

Structure Activity ◽

Endothelial Growth Factor

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Fortgeschrittenes medulläres Schilddrüsenkarzinom: Vandetanib verbessert das progressionsfreie Überleben

Onkologische Welt ◽

10.1055/s-0038-1631032 ◽

2012 ◽

Vol 03 (02) ◽

pp. 93-92

Author(s):

Alexander Kretzschmar

Keyword(s):

Vascular Endothelial Growth Factor ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Phase Iii ◽

Vascular Endothelial ◽

Medulläres Schilddrüsenkarzinom ◽

Epidermal Growth ◽

Endothelial Growth Factor

Vandetanib ist ein oraler Hemmer des RET-Kinase-, VEGF (Vascular Endothelial Growth Factor Receptor)- und EGFR (Epidermal Growth Factor Receptor)-Signalwegs. In einer zulassungsrelevanten, randomisierten, doppelblinden, placebokontrollierten Phase- III-Studie verlängerte der Tyrosinkinasehemmer das progressionsfreie Überleben (PFS) signifikant länger als Placebo.

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Expression des „Epidermal Growth-Factor Receptor“ (EGFR) und des „Vascular Endothelial Growth Factor“ (VEGF) bei Lymphangioleiomyomatose (LAM)

Pneumologie ◽

10.1055/s-2006-934022 ◽

2006 ◽

Vol 60 (S 1) ◽

Author(s):

H Watz ◽

K Engels ◽

M Amthor ◽

D Kirsten ◽

H Magnussen

Keyword(s):

Vascular Endothelial Growth Factor ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Epidermal Growth ◽

Endothelial Growth Factor

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Faculty Opinions recommendation of Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1163678.625451 ◽

2009 ◽

Author(s):

David Bates

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Lymphatic Vessel ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endogenous Inhibitor ◽

Vessel Growth ◽

Alternatively Spliced ◽

Endothelial Growth Factor

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Faculty Opinions recommendation of Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11744956.12828054 ◽

2011 ◽

Author(s):

Asma Nusrat

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Receptor Antagonism ◽

Endothelial Growth Factor ◽

Α2β1 Integrin

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Faculty Opinions recommendation of Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11744956.13740054 ◽

2011 ◽

Author(s):

Richard L Stevens

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Receptor Antagonism ◽

Endothelial Growth Factor ◽

Α2β1 Integrin

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Faculty Opinions recommendation of 111In-bevacizumab imaging of renal cell cancer and evaluation of neoadjuvant treatment with the vascular endothelial growth factor receptor inhibitor sorafenib.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717697854.793153053 ◽

2012 ◽

Author(s):

Hendrik van Poppel ◽

Yuri Tolkach

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Renal Cell Cancer ◽

Renal Cell ◽

Cell Cancer ◽

Neoadjuvant Treatment ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Inhibitor

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