Synthesis and Structure−Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Inhibitors of the Fibroblast Growth Factor Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinases

Andrew M. Thompson; Amy M. Delaney; James M. Hamby; Mel C. Schroeder; Teresa A. Spoon; Sheila M. Crean; H. D. Hollis Showalter; William A. Denny

doi:10.1021/jm0500931

Synthesis and Structure−Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Inhibitors of the Fibroblast Growth Factor Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinases

Journal of Medicinal Chemistry ◽

10.1021/jm0500931 ◽

2005 ◽

Vol 48 (14) ◽

pp. 4628-4653 ◽

Cited By ~ 35

Author(s):

Andrew M. Thompson ◽

Amy M. Delaney ◽

James M. Hamby ◽

Mel C. Schroeder ◽

Teresa A. Spoon ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Structure Activity ◽

Dual Inhibitors ◽

Endothelial Growth Factor

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Expression of Epidermal Growth Factor Receptor (EGF-R), Vascular Endothelial Growth Factor Receptor (VEGF-R) and Fibroblast Growth Factor Receptor (FGF-R) Systems in Porcine Oviduct and Endometrium during the Time of Implantation

Journal of Reproduction and Development ◽

10.1262/jrd.50.269 ◽

2004 ◽

Vol 50 (3) ◽

pp. 269-278 ◽

Cited By ~ 27

Author(s):

Karin WOLLENHAUPT ◽

Harald WELTER ◽

Ralf EINSPANIER ◽

Noboru MANABE ◽

Klaus-Peter BRÜSSOW

Keyword(s):

Vascular Endothelial Growth Factor ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Epidermal Growth ◽

Endothelial Growth Factor

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Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm0501275 ◽

2005 ◽

Vol 48 (12) ◽

pp. 3991-4008 ◽

Cited By ~ 46

Author(s):

Robert M. Borzilleri ◽

Xiaoping Zheng ◽

Ligang Qian ◽

Christopher Ellis ◽

Zhen-wei Cai ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Design Synthesis ◽

Endothelial Growth Factor ◽

Orally Active

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MicroRNA-16 and MicroRNA-424 Regulate Cell-Autonomous Angiogenic Functions in Endothelial Cells via Targeting Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.111.236521 ◽

2011 ◽

Vol 31 (11) ◽

pp. 2595-2606 ◽

Cited By ~ 170

Author(s):

Aránzazu Chamorro-Jorganes ◽

Elisa Araldi ◽

Luiz O.F. Penalva ◽

Devraj Sandhu ◽

Carlos Fernández-Hernando ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Endothelial Cells ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Endothelial Growth Factor

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Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor

Cancer Gene Therapy ◽

10.1038/sj.cgt.7700478 ◽

2002 ◽

Vol 9 (8) ◽

pp. 633-640 ◽

Cited By ~ 48

Author(s):

Tadashi Ogawa ◽

Koichi Takayama ◽

Nobuyuki Takakura ◽

Seigo Kitano ◽

Hikaru Ueno

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Soluble Receptors ◽

Inhibition Of Tumor Growth ◽

Endothelial Growth Factor

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Fibroblast Growth Factor Receptor 1 (FGFR1), Partly Related to Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) and Microvessel Density, is an Independent Prognostic Factor for Non-Small Cell Lung Cancer

Medical Science Monitor ◽

10.12659/msm.899005 ◽

2017 ◽

Vol 23 ◽

pp. 247-257 ◽

Cited By ~ 9

Author(s):

Dan Pu ◽

Jiewei Liu ◽

Zhixi Li ◽

Jiang Zhu ◽

Mei Hou

Keyword(s):

Lung Cancer ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Small Cell ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Small Cell Lung ◽

Endothelial Growth Factor

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Discovery of Brivanib Alaninate: A Dual Vascular Endothelial Growth Factor and Fibroblast Growth Factor Receptor Inhibitor

Kinase Inhibitor Drugs ◽

10.1002/9780470524961.ch6 ◽

2009 ◽

pp. 131-166

Author(s):

Rajeev S. Bhide ◽

Joseph Fargnoli

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Brivanib Alaninate ◽

Endothelial Growth Factor ◽

Receptor Inhibitor

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The effects of liver impairment on the pharmacokinetics of brivanib, a dual inhibitor of fibroblast growth factor receptor and vascular endothelial growth factor receptor tyrosine kinases

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-013-2168-z ◽

2013 ◽

Vol 72 (1) ◽

pp. 53-64 ◽

Cited By ~ 3

Author(s):

Anthony El-Khoueiry ◽

James A. Posey ◽

Juan Ramón Castillo Ferrando ◽

Smitha S. Krishnamurthi ◽

Shariq Syed ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinases ◽

Fibroblast Growth Factor Receptor ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Dual Inhibitor ◽

Liver Impairment ◽

Endothelial Growth Factor

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The Antiangiogenic Activity in Xenograft Models of Brivanib, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinases

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-09-0472 ◽

2010 ◽

Vol 9 (2) ◽

pp. 369-378 ◽

Cited By ~ 53

Author(s):

Rajeev S. Bhide ◽

Louis J. Lombardo ◽

John T. Hunt ◽

Zhen-wei Cai ◽

Joel C. Barrish ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Dual Inhibitor ◽

Antiangiogenic Activity ◽

Xenograft Models ◽

Endothelial Growth Factor

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Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor‐induced signaling

The FASEB Journal ◽

10.1096/fj.01-0835fje ◽

2002 ◽

Vol 16 (10) ◽

pp. 1283-1285 ◽

Cited By ~ 15

Author(s):

Konstantin V. Stoletov ◽

Kirsty E. Ratcliffe ◽

Bruce I. Terman

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Endothelial Growth Factor

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Ectopic Activity of Fibroblast Growth Factor Receptor 1 in Hepatocytes Accelerates Hepatocarcinogenesis by Driving Proliferation and Vascular Endothelial Growth Factor–Induced Angiogenesis

Cancer Research ◽

10.1158/0008-5472.can-05-2412 ◽

2006 ◽

Vol 66 (3) ◽

pp. 1481-1490 ◽

Cited By ~ 42

Author(s):

Xinqiang Huang ◽

Chundong Yu ◽

Chengliu Jin ◽

Masashi Kobayashi ◽

Courtney A. Bowles ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Ectopic Activity ◽

Endothelial Growth Factor

Download Full-text