Synthesis and in Vitro Evaluation of18F- and19F-Labeled Insulin:  A New Radiotracer for PET-based Molecular Imaging Studies

2006 ◽  
Vol 49 (4) ◽  
pp. 1466-1474 ◽  
Author(s):  
Katharina J. Guenther ◽  
Sabesan Yoganathan ◽  
Robert Garofalo ◽  
Thomas Kawabata ◽  
Thomas Strack ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Imaging Studies ◽  
In Vitro Evaluation

scholarly journals In vitro and in vivo sigma 1 receptor imaging studies in different disease states

2020 ◽  
Author(s):  
Hebaalla Agha ◽  
Christopher R. McCurdy
Keyword(s):  
Clinical Trials ◽  
Molecular Imaging ◽  
Receptor Imaging ◽  
Imaging Studies ◽  
Sigma 1 Receptor ◽  
The Road ◽  
Disease States ◽  
Sigma 1

Molecular imaging studies have paved the road for the development of successful σ1R ligands currently in clinical trials.

scholarly journals Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2451
Author(s):  
Paul Cumming ◽  
Milan Scheidegger ◽  
Dario Dornbierer ◽  
Mikael Palner ◽  
Boris B. Quednow ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Single Photon ◽  
Ex Vivo ◽  
Specific Binding ◽  
Photon Emission ◽  
Imaging Studies ◽  
Active Metabolites ◽  
Positron Emission ◽  
Imaging Research

Hallucinogens are a loosely defined group of compounds including LSD, N,N-dimethyltryptamines, mescaline, psilocybin/psilocin, and 2,5-dimethoxy-4-methamphetamine (DOM), which can evoke intense visual and emotional experiences. We are witnessing a renaissance of research interest in hallucinogens, driven by increasing awareness of their psychotherapeutic potential. As such, we now present a narrative review of the literature on hallucinogen binding in vitro and ex vivo, and the various molecular imaging studies with positron emission tomography (PET) or single photon emission computer tomography (SPECT). In general, molecular imaging can depict the uptake and binding distribution of labelled hallucinogenic compounds or their congeners in the brain, as was shown in an early PET study with N1-([11C]-methyl)-2-bromo-LSD ([11C]-MBL); displacement with the non-radioactive competitor ketanserin confirmed that the majority of [11C]-MBL specific binding was to serotonin 5-HT2A receptors. However, interactions at serotonin 5HT1A and other classes of receptors and pleotropic effects on second messenger pathways may contribute to the particular experiential phenomenologies of LSD and other hallucinogenic compounds. Other salient aspects of hallucinogen action include permeability to the blood–brain barrier, the rates of metabolism and elimination, and the formation of active metabolites. Despite the maturation of radiochemistry and molecular imaging in recent years, there has been only a handful of PET or SPECT studies of radiolabeled hallucinogens, most recently using the 5-HT2A/2C agonist N-(2[11CH3O]-methoxybenzyl)-2,5-dimethoxy- 4-bromophenethylamine ([11C]Cimbi-36). In addition to PET studies of target engagement at neuroreceptors and transporters, there is a small number of studies on the effects of hallucinogenic compounds on cerebral perfusion ([15O]-water) or metabolism ([18F]-fluorodeoxyglucose/FDG). There remains considerable scope for basic imaging research on the sites of interaction of hallucinogens and their cerebrometabolic effects; we expect that hybrid imaging with PET in conjunction with functional magnetic resonance imaging (fMRI) should provide especially useful for the next phase of this research.

Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting

2010 ◽  
Vol 45 (2) ◽  
pp. 423-429 ◽  
Author(s):  
Sandra Dorbes ◽  
Béatrice Mestre-Voegtlé ◽  
Yvon Coulais ◽  
Claude Picard ◽  
Sandrine Silvente-Poirot ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Imaging Agents ◽  
Receptor Targeting ◽  
In Vitro Evaluation ◽  
Molecular Imaging Agents ◽  
Cck2 Receptor

scholarly journals Correction to Synthesis and in Vitro Evaluation of a Biotinylated Dextran-Derived Probe for Molecular Imaging

2012 ◽  
Vol 3 (8) ◽  
pp. 643-643
Author(s):  
Anurag Mishra ◽  
Rajendra Joshi ◽  
Jörn Engelmann ◽  
Nikos K. Logothetis
Keyword(s):  
Molecular Imaging ◽  
In Vitro Evaluation ◽  
Biotinylated Dextran

Lithiation of Functionalized Fluoroquinolines:  Synthesis of Dihalo-2-phenylquinoline-4-carboxamides and in Vitro Evaluation as NK-3 Receptor Ligands for Medical Imaging Studies

2004 ◽  
Vol 69 (7) ◽  
pp. 2622-2625 ◽  
Author(s):  
Idriss Bennacef ◽  
Sylvie Tymciu ◽  
Martine Dhilly ◽  
Florence Mongin ◽  
Guy Quéguiner ◽  
...  
Keyword(s):  
Medical Imaging ◽  
Receptor Ligands ◽  
Imaging Studies ◽  
In Vitro Evaluation

scholarly journals Synthesis and in Vitro Evaluation of a Biotinylated Dextran-Derived Probe for Molecular Imaging

2012 ◽  
Vol 3 (4) ◽  
pp. 268-273 ◽  
Author(s):  
Anurag Mishra ◽  
Rajendra Joshi ◽  
Jörn Engelmann ◽  
Nikos K. Logothetis
Keyword(s):  
Molecular Imaging ◽  
In Vitro Evaluation ◽  
Biotinylated Dextran

scholarly journals Lithiation of Functionalized Fluoroquinolines: Synthesis of Dihalo-2-phenylquinoline-4-carboxamides and in vitro Evaluation as NK-3 Receptor Ligands for Medical Imaging Studies.

ChemInform ◽  
2004 ◽  
Vol 35 (32) ◽  
Author(s):  
Idriss Bennacef ◽  
Sylvie Tymciu ◽  
Martine Dhilly ◽  
Florence Mongin ◽  
Guy Queguiner ◽  
...  
Keyword(s):  
Medical Imaging ◽  
Receptor Ligands ◽  
Imaging Studies ◽  
In Vitro Evaluation

In vitro evaluation of IL-18 effects in Crohn's disease

2001 ◽  
Vol 120 (5) ◽  
pp. A316-A317
Author(s):  
P MAERTEN ◽  
S COLPAERT ◽  
Z LIU ◽  
K GEBOES ◽  
J CEUPPENS ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
In Vitro Evaluation
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