- Formulation, Characterization, and in vitro Evaluation of Quantum Dots Loaded in Poly(Lactide)-Vitamin E TPGS Nanoparticles for Cellular and Molecular Imaging

2014 ◽  
pp. 928-951
Keyword(s):  
Quantum Dots ◽  
Vitamin E ◽  
Molecular Imaging ◽  
In Vitro Evaluation ◽  
Vitamin E Tpgs

Preparation and in vivo/in vitro evaluation of formononetin phospholipid/vitamin E TPGS micelles

2015 ◽  
Vol 24 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Xudong Cheng ◽  
Hongmei Yan ◽  
Xiaobin Jia ◽  
Zhenhai Zhang
Keyword(s):  
Vitamin E ◽  
In Vitro Evaluation ◽  
Vitamin E Tpgs

scholarly journals Liquid crystalline systems containing Vitamin E TPGS for the controlled transdermal nicotine delivery

2016 ◽  
Vol 52 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Lívia Neves Borgheti-Cardoso ◽  
Fabiana Testa Moura de Carvalho Vicentini ◽  
Tais Gratieri ◽  
Maria Vitória Lopes Badra Bentley
Keyword(s):  
Vitamin E ◽  
Liquid Crystalline ◽  
Visual Analysis ◽  
Skin Permeation ◽  
Skin Irritation ◽  
Cubic Phase ◽  
Nicotine Delivery ◽  
Vitamin E Tpgs ◽  
Transdermal Nicotine

ABSTRACT Transdermal nicotine patches have been used in smoking cessation therapy, suggested for the treatment of skin disorders with eosinophilic infiltration and have been found to improve attention performance in patients with Alzheimer's disease and age-associated memory impairment. However, skin irritation with extended patch use is still a problem. The aim of this work was to develop a simple to prepare liquid crystalline system containing vitamin E TPGS that would be able to control nicotine delivery and reduce irritation and sensitization problems. The liquid crystalline phases were macroscopically characterized by visual analysis and examined microscopically under a polarized light microscope. Topical and transdermal delivery of nicotine were investigated in vitro using porcine ear skin mounted on a Franz diffusion cell. Nicotine skin permeation from the developed cubic phase followed zero-order kinetics (r = 0.993) and was significantly enhanced after 12 h when compared to the control formulation (nicotine solution) (p < 0.05) (138.86 ± 20.44 and 64.91 ± 4.06 μg/cm2, respectively). Cubic phase was also able to target viable skin layers in comparison to control solution (8.18 ± 1.89 and 2.63 ± 2.51 μg/cm2, respectively). Further studies to evaluate skin sensitization and irritation are now necessary.

scholarly journals In vitro blood compatibility evaluation method: incubating while rotating hemodialyzers filled with fresh human blood

2020 ◽  
Author(s):  
Kinue Kamata ◽  
Yoshihiro Hatanaka ◽  
Hiromi Tanaka ◽  
Satoru Inoue ◽  
Yusuke Tokimizu ◽  
...  
Keyword(s):  
Vitamin E ◽  
Blood Cell ◽  
Experimental Method ◽  
Human Blood ◽  
Evaluation Method ◽  
Blood Compatibility ◽  
In Vitro Evaluation ◽  
Dialysis Membranes ◽  
Anti Inflammatory

AbstractOne of the often-used methods for in vitro evaluation of the blood compatibility of hemodialysis membranes is the circulation of human blood through a miniaturized hemodialyzer. The use of a rather small amount of human blood in its evaluation is one advantage of this method. However, because it is manufactured by a different process than actual ones, a miniaturized hemodialyzer membrane cannot always preserve the properties of actual hemodialyzers. To address this problem, we established a new experimental method that uses a relatively small amount of human blood and actual dialyzers. In this method, a test hemodialyzer and a control hemodialyzer filled with human blood obtained from the same donor is slowly rotated to prevent spontaneous blood cell sedimentation for 4 h at 37 °C. By use of this method, we were able to compare blood compatibility between a polysulfone (PS) membrane and a vitamin E (VE)-bonded PS membrane in terms of their relative antithrombotic, antioxidative, and anti-inflammatory properties. Consistent with many previous reports, the results clearly showed that compared with the PS membrane, VE-bonded PS membrane is more blood compatible. These findings suggest that our method is applicable, at least to in vitro blood compatibility evaluation of PS type dialysis membranes.

Antifungal efficacy of Itraconazole loaded PLGA-nanoparticles stabilized by vitamin-E TPGS: In vitro and ex vivo studies

2019 ◽  
Vol 161 ◽  
pp. 87-95 ◽  
Author(s):  
Adel A. Alhowyan ◽  
Mohammad A. Altamimi ◽  
Mohd Abul Kalam ◽  
Abdul Arif Khan ◽  
Mohamed Badran ◽  
...  
Keyword(s):  
Vitamin E ◽  
Ex Vivo ◽  
Plga Nanoparticles ◽  
Vitamin E Tpgs ◽  
Antifungal Efficacy
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