Design and Synthesis of Dipeptidyl Glutaminyl Fluoromethyl Ketones as Potent Severe Acute Respiratory Syndrome Coronovirus (SARS-CoV) Inhibitors

2006 ◽  
Vol 49 (3) ◽  
pp. 1198-1201 ◽  
Author(s):  
Han-Zhong Zhang ◽  
Hong Zhang ◽  
William Kemnitzer ◽  
Ben Tseng ◽  
Jindrich Cinatl, ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Design And Synthesis

Design and Synthesis of De Novo Boomerang Shaped Molecules and their In Silico & SERS-based Interactions with SARS-CoV-2 Spike Protein and ACE2

2021 ◽  
Author(s):  
Amrutham Linet ◽  
Manu M Joseph ◽  
Haritha Mambatta ◽  
Shamna k ◽  
Sunil varughese ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Receptor Binding ◽  
In Silico ◽  
De Novo ◽  
Binding Domain ◽  
Spike Protein ◽  
Epithelial Tissue ◽  
Receptor Binding Domain ◽  
Design And Synthesis ◽  
Recent Outbreak

The recent outbreak of the COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which infects human epithelial tissue by interaction of the receptor-binding domain of its spike...

scholarly journals Design and Synthesis of Cinanserin Analogs as Severe Acute Respiratory Syndrome Coronavirus 3CL Protease Inhibitors

2008 ◽  
Vol 56 (10) ◽  
pp. 1400-1405 ◽  
Author(s):  
Qingang Yang ◽  
Lili Chen ◽  
Xuchang He ◽  
Zhenting Gao ◽  
Xu Shen ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Protease Inhibitors ◽  
Design And Synthesis ◽  
3Cl Protease

scholarly journals Design and synthesis of some imidazole derivatives: theoretical evaluation of interaction with a coronavirus (HCoV-NL63)

2020 ◽  
Vol 10 (4) ◽  
pp. 5869-5874 ◽  
Keyword(s):  
Biological Activity ◽  
Severe Acute Respiratory Syndrome ◽  
Protein Surface ◽  
Theoretical Evaluation ◽  
Imidazole Derivatives ◽  
Design And Synthesis ◽  
Docking Model ◽  
Keto Derivative

Some compounds have been developed for the treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) using different protocols; however, some methods use different reagents which are dangerous and require special conditions. the objective of this investigation was to synthesize some imidazole derivatives from 2-methyl-5-nitroimidazole using some reactions such as etherification, reduction, and a hydroxy-keto derivative formation. In addition, the theoretical activity of imidazole derivatives (compounds 2, 3 and 5-8) was evaluated in a docking model using hydroxylchloroquine and favipiravir as controls. The results showed that 1) compounds 3 and 5 have a higher affinity by 5ewp protein surface compared with hydroxylchloroquine, favipiravir, 2 and 6-8. In conclusion, compounds 3 and 5 could inhibit the biological activity of coronavirus.

Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors

2005 ◽  
Vol 48 (22) ◽  
pp. 6767-6771 ◽  
Author(s):  
Arun K. Ghosh ◽  
Kai Xi ◽  
Kiira Ratia ◽  
Bernard D. Santarsiero ◽  
Wentao Fu ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Protease Inhibitors ◽  
Design And Synthesis

scholarly journals Design and Synthesis of a Lactam-Steroid Derivative and their Theoretical Interaction with a SAR-COV2

2020 ◽  
Vol 11 (1) ◽  
pp. 7621-7631
Keyword(s):  
Theoretical Model ◽  
Binding Energy ◽  
Severe Acute Respiratory Syndrome ◽  
Protein Surface ◽  
Design And Synthesis ◽  
Docking Model ◽  
Steroid Derivative

Several drugs have been developed for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV) using different protocols; however, some methods use different reagents that are dangerous and require special conditions. The objective of this research was to synthesize a Lactam-steroid derivative to evaluate its theoretical interaction with SARS-CoV using at 6LU7-protein as a theoretical model. Furthermore, this interaction was carried out in a docking model using hydroxychloroquine and favipiravir as controls. The results showed that the binding energy involved in the interaction of the lactam-steroid derivative with 6LU7 protein surface was lower compared with both hydroxychloroquine and favipiravir. In conclusion, the lactam-steroid derivative could be an alternative therapeutic to treatment of SARS-CoV.

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

Tailoring microstructures of materials through biomimetics

1993 ◽  
Vol 51 ◽  
pp. 500-501
Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay
Keyword(s):  
Chemical Properties ◽  
Design And Synthesis ◽  
Structure Sensitive ◽  
Macro Scale ◽  
Methods Of Synthesis ◽  
Successive Level ◽  
Engineering Materials ◽  
Physical And Chemical ◽  
And Chemical Properties ◽  
Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

Perceptions about Severe Acute Respiratory Syndrome Experience Scales

2006 ◽  
Author(s):  
Robert G. Maunder ◽  
William J. Lancee ◽  
Kenneth E. Balderson ◽  
Jocelyn P. Bennett ◽  
Bjug Borgundvaag ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome

Design and synthesis of azaisoflavones

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
B Kang ◽  
YJ Jung ◽  
R Jeon
Keyword(s):  
Design And Synthesis
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