Parallel Solution-Phase and Microwave-Assisted Synthesis of NewS-DABO Derivatives Endowed with Subnanomolar Anti-HIV-1 Activity

2005 ◽  
Vol 48 (25) ◽  
pp. 8000-8008 ◽  
Author(s):  
Fabrizio Manetti ◽  
José A. Esté ◽  
Imma Clotet-Codina ◽  
Mercedes Armand-Ugón ◽  
Giovanni Maga ◽  
...  
Keyword(s):  
Solution Phase ◽  
Microwave Assisted Synthesis ◽  
Parallel Solution ◽  
Microwave Assisted ◽  
Anti Hiv ◽  
Hiv 1

New chalcones and thiopyrimidine analogues derived from mefenamic acid: microwave-assisted synthesis, anti-HIV activity and cytotoxicity as antileukemic agents

2017 ◽  
Vol 72 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Hanan A. Al-Hazam ◽  
Zeki A. Al-Shamkani ◽  
Najim A. Al-Masoudi ◽  
Bahjat A. Saeed ◽  
Christophe Pannecouque
Keyword(s):  
Mefenamic Acid ◽  
Leukemia Cells ◽  
Basic Medium ◽  
Microwave Assisted Synthesis ◽  
Schmidt Reaction ◽  
Microwave Assisted ◽  
Amide Derivatives ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Hiv 1

AbstractThe development of new HIV non-nucleoside reverse transcriptase inhibitors offers the possibility of generating structures of increased potency. To this end, coupling of mefenamic acid (4) with 4-amino-acetophenone (6) in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine (DMAP) reagents afforded 4-(acetyphenyl)-2-((2,3-dimethylphenyl)amino)benzamide (7). Analogously, treatment of mefenamyl chloride (5) prepared from 4 with 6 under microwave irradiation (MWI) afforded 7. A new series of substituted chalconyl-incorporated amide derivatives of mefenamic acid 8–13 were synthesized from condensation of 7 with various substituted benzaldehydes via the Claisen–Schmidt reaction. Treatment of 8 and 11 with thiourea in a basic medium afforded the thiopyrimidine analogues 14 and 15, respectively. The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compounds 9 and 11 showed cytotoxicity values of 2.17 and 2.06 μm, respectively, against mock-infected MT-4 cells (C type adult T leukemia cells), which considered to be promising antileukemic agents.

Abacavir Prodrugs: Microwave-Assisted Synthesis and Their Evaluation of anti-HIV Activities.

ChemInform ◽  
2006 ◽  
Vol 37 (29) ◽  
Author(s):  
Dharmarajan Sriram ◽  
Perumal Yogeeswari ◽  
Naga Sirisha Myneedu ◽  
Vivek Saraswat
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv

Microwave-Assisted Combinatorial Synthesis of 2-Alkyl-2-(NArylsulfonylindol- 3-yl)-3-N-Acyl-5-Aryl-1,3,4-Oxadiazolines as Anti-HIV- 1 Agents

2013 ◽  
Vol 16 (5) ◽  
pp. 400-407 ◽  
Author(s):  
Zhi-Ping Che ◽  
Ning Huang ◽  
Xiang Yu ◽  
Liu-Meng Yang ◽  
Jun-Qiang Ran ◽  
...  
Keyword(s):  
Combinatorial Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv ◽  
Hiv 1

Microwave-assisted synthesis and anti-HIV activity of new benzenesulfonamides bearing 2,5-disubstituted-1,3,4-oxadiazole moiety

2007 ◽  
Vol 18 (4) ◽  
pp. 425-431 ◽  
Author(s):  
Muhammad Zareef ◽  
Rashid Iqbal ◽  
Najim A. Al-Masoudi ◽  
Javid H. Zaidi ◽  
Muhammad Arfan
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv

scholarly journals Solution-Phase Microwave-Assisted Synthesis of Unsubstituted and Modified α-Quinque- and Sexithiophenes.

ChemInform ◽  
2004 ◽  
Vol 35 (46) ◽  
Author(s):  
M. Melucci ◽  
G. Barbarella ◽  
M. Zambianchi ◽  
P. Di Pietro ◽  
A. Bongini
Keyword(s):  
Solution Phase ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

Microwave-assisted synthesis, molecular docking and anti-HIV activities of some drug-like quinolone derivatives

2020 ◽  
Vol 29 (6) ◽  
pp. 1067-1076 ◽  
Author(s):  
Ahmed M. Jassem ◽  
Adil M. Dhumad ◽  
Faeza A. Almashal ◽  
Jasim M. Alshawi
Keyword(s):  
Molecular Docking ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv ◽  
Quinolone Derivatives

scholarly journals Microwave-Assisted Synthesis of Fluoroquinolones and Their Nucleosides as Inhibitors of HIV Integrase

2006 ◽  
Vol 71 (7) ◽  
pp. 978-990 ◽  
Author(s):  
Martina M. Adams ◽  
Jan W. Bats ◽  
Nadja V. Nikolaus ◽  
Myriam Witvrouw ◽  
Zeger Debyser ◽  
...  
Keyword(s):  
Microwave Assisted Synthesis ◽  
Hiv Integrase ◽  
Inhibitory Effects ◽  
Microwave Assisted ◽  
Microwave Application ◽  
Anti Conformation ◽  
One Step ◽  
New Type ◽  
The One ◽  
Hiv 1

Six fluoroquinolone ribonucleosides were synthesized by using microwave irradiation starting from fluoroanilines. In most cases the microwave application proved superior in time and yield, especially the one step decarboxylation of the carboxyquinolone esters3a-3cand the Vorbrüggen glycosylation. The former led to the new type of fluoroquinolone ribosides8a-8c. Compound8cin the crystal structure showed C3'-endo and anti conformation. The nucleosides were examined, but found inactive against the replication of HIV-1(IIIB) in cell culture, while they were toxic for the cells at a 50% cytotoxic concentration ranging from 31 to >125 μg/ml. But measurements of the inhibitory effects against HIV-1 integrase enzymatic activity showed an interesting activity for compound8c.

Facile microwave-assisted synthesis and effective photocatalytic hydrogen generation of Zn2GeO4 with different morphology

RSC Advances ◽  
2014 ◽  
Vol 4 (29) ◽  
pp. 15048-15054 ◽  
Author(s):  
Min Yang ◽  
Ying Ji ◽  
Wei Liu ◽  
Ying Wang ◽  
Xiaoyang Liu
Keyword(s):  
Hydrogen Generation ◽  
Solution Phase ◽  
Microwave Assisted Synthesis ◽  
Hexagonal Prism ◽  
Single Crystalline ◽  
Phase Approach ◽  
Microwave Assisted ◽  
Photocatalytic Hydrogen Generation

Single-crystalline hexagonal prism Zn2GeO4 nanorods and hierarchical Zn2GeO4 microspheres have been successfully synthesized via a facile microwave-assisted solution-phase approach.

Sign in / Sign up

Export Citation Format

Share Document