Synthesis and Characterization of Platinum(IV) Anticancer Drugs with Functionalized Aromatic Carboxylate Ligands:  Influence of the Ligands on Drug Efficacies and Uptake

2005 ◽  
Vol 48 (25) ◽  
pp. 8060-8069 ◽  
Author(s):  
Wee Han Ang ◽  
Sébastien Pilet ◽  
Rosario Scopelliti ◽  
François Bussy ◽  
Lucienne Juillerat-Jeanneret ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Synthesis And Characterization ◽  
Carboxylate Ligands ◽  
Aromatic Carboxylate

scholarly journals cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339

2017 ◽  
Vol 46 (35) ◽  
pp. 11925-11941 ◽  
Author(s):  
Gabriel E. Büchel ◽  
Susanne Kossatz ◽  
Ahmad Sadique ◽  
Peter Rapta ◽  
Michal Zalibera ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Synthesis And Characterization ◽  
Cis Isomer ◽  
The Way

The synthesis and characterization of cis-[OsIVCl4(κN2-1H-indazole)2] and its 1e-reduced analog are reported.

Synthesis and Characterization of New Hydridoiridium Complexes Containing Carboxylate Ligands

1994 ◽  
Vol 33 (16) ◽  
pp. 3473-3480 ◽  
Author(s):  
Miguel A. Esteruelas ◽  
Maria P. Garcia ◽  
Fernando J. Lahoz ◽  
Marta Martin ◽  
Javier Modrego ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Carboxylate Ligands

scholarly journals Synthesis and Characterization of New Ethylenediamine Platinum(IV) Complexes Containing Lipophilic Carboxylate Ligands

1995 ◽  
Vol 2 (1) ◽  
pp. 57-63 ◽  
Author(s):  
M. Galanski ◽  
B. K. Keppler
Keyword(s):  
Axial Position ◽  
Synthesis And Characterization ◽  
Equatorial Position ◽  
Spectroscopic Techniques ◽  
Acyl Halide ◽  
Carboxylate Ligands ◽  
New Class ◽  
Carboxylate Groups ◽  
Long Chain

A series of new ethylenediamine (en) platinum(IV) complexes of the type Pt(IV)enX2A2 , with X2 = cyclobutane-1,1-dicarboxylato (CBDCA), dichloro or bis(decanoato) and A = acetato, dodecanoato, tetradecanoato, hexadecanoato, octadecanoato, adamantanecarboxylato (Ad) or 3α, 12α -diformoxy-5β-cholato (DFCA) were synthesized and characterized by elemental analysis, infrared and NMR (H1 and C13) spectroscopic techniques. Previous platinum(IV) compounds were usually restricted to trans-dihydroxo or trans-dichloro platinum(IV) complexes. Recently trans-dicarboxylato platinum(IV) complexes with mainly acetate, trifluoracetate or short-chain carboxylate groups (<11 carbons) in the axial position have been described in the literature[1,2,3]. In this paper we report on the synthesis and characterization of a new class of ethylenediamine platinum(IV) compounds that have high lipophilic long-chain carboxylate ligands either in the axial or equatorial position. The platinum(IV) compounds with the lipophilic trans-carboxylate ligands in the axial position were prepared by acylation of the trans-dihydroxo platinum(IV) species using an acyl halide in the presence of pyridine. In contrast to previous publications[1] the yields were excellent (up to 94%!).

Synthesis and Characterization of Carboxylic Acids Bearing Poly(ethylene glycol) Chains

Synlett ◽  
2017 ◽  
Vol 29 (05) ◽  
pp. 556-559 ◽  
Author(s):  
Tetsuaki Fujihara ◽  
Yasushi Tsuji ◽  
Motoi Satou ◽  
Jun Terao
Keyword(s):  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
Carboxylic Acids ◽  
Aerobic Oxidation ◽  
Synthesis And Characterization ◽  
Poly Ethylene Glycol ◽  
Carboxylate Ligands ◽  
Poly Ethylene

Carboxylic acids 1a and 1b bearing three poly(ethylene glycol) (PEG) chains and carboxylic acid 1c bearing one PEG chain were designed and synthesized. The carboxylic acids 1a–c were fully characterized by NMR and ESI-HRMS analyses. In a Pd-catalyzed aerobic oxidation of 1-phenylethanol, 1a and 1b worked well as carboxylate ligands.

Designing, synthesis, and characterization of some novel coumarin derivatives as probable anticancer drugs

2012 ◽  
Vol 22 (9) ◽  
pp. 4146-4157 ◽  
Author(s):  
Darla Mark Manidhar ◽  
Rajesh Kumar Kesharwani ◽  
N. Bakthavatchala Reddy ◽  
C. Suresh Reddy ◽  
Krishna Misra
Keyword(s):  
Anticancer Drugs ◽  
Synthesis And Characterization ◽  
Coumarin Derivatives

Synthesis and Characterization of a [Mn 12 O 12 (O 2 CR) 16 (H 2 O) 4 ] Complex Bearing Paramagnetic Carboxylate Ligands. Use of a Modified Acid Replacement Synthetic Approach

2003 ◽  
Vol 134 (2) ◽  
pp. 265-276 ◽  
Author(s):  
Philippe Gerbier ◽  
Daniel Ruiz-Molina ◽  
Neus Domingo ◽  
David B. Amabilino ◽  
Jos� Vidal-Gancedo ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Synthetic Approach ◽  
Carboxylate Ligands

Synthesis and characterization of dimethyl 6-bromo-2H-chromene-2,3-dicarboxylate: thermodynamic and kinetics investigations by computational and experimental studies

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 111239-111249 ◽  
Author(s):  
Osman Asheri ◽  
Sayyed Mostafa Habibi-Khorassani ◽  
Mehdi Shahraki
Keyword(s):  
Anticancer Drugs ◽  
Biological Activities ◽  
Experimental Studies ◽  
Modern Society ◽  
Synthesis And Characterization

Modern society is dependent on synthetic chromene derivatives for use as drugs, including anticancer drugs, and for their biological activities.

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