Synthesis and characterization of a series of achiral and chiral mono- and bis[(dien)Pt(II)I]I derivatives as potential DNA and RNA structure probes and anticancer drugs

1992 ◽  
Vol 31 (17) ◽  
pp. 3636-3646 ◽  
Author(s):  
Rushdi Alul ◽  
Martin B. Cleaver ◽  
John Stephen Taylor
Keyword(s):  
Anticancer Drugs ◽  
Rna Structure ◽  
Synthesis And Characterization ◽  
Dna And Rna

scholarly journals cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339

2017 ◽  
Vol 46 (35) ◽  
pp. 11925-11941 ◽  
Author(s):  
Gabriel E. Büchel ◽  
Susanne Kossatz ◽  
Ahmad Sadique ◽  
Peter Rapta ◽  
Michal Zalibera ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Synthesis And Characterization ◽  
Cis Isomer ◽  
The Way

The synthesis and characterization of cis-[OsIVCl4(κN2-1H-indazole)2] and its 1e-reduced analog are reported.

scholarly journals Structural characterization of DNA and RNA sequences recognized by the gene 5 protein of bacteriophage fd

1999 ◽  
Vol 339 (3) ◽  
pp. 525-531 ◽  
Author(s):  
Antony W. OLIVER ◽  
G. Geoff KNEALE
Keyword(s):  
Dna Sequence ◽  
Rna Structure ◽  
Gel Filtration ◽  
Rna Sequences ◽  
Rna Translation ◽  
Translational Repressor ◽  
Dna And Rna ◽  
Gene 5 Protein ◽  
Na Ions

The single-stranded DNA sequence d(GT5G4CT4C) occurs close to the origin of replication within the intergenic region of the viral strand of bacteriophage fd. The RNA analogue of this sequence r(GU5G4CU4C) forms part of the untranslated leader sequence of the gene 2 mRNA and is specifically bound by the fd gene 5 protein in its role as a translational repressor. The structure of these sequences is likely to have an important role in the control of both DNA replication and RNA translation in the phage. We show that this 16 nt sequence, in both a DNA and an RNA context, can exist in a structured and unstructured form as determined by high-resolution gel filtration and non-denaturing gel electrophoresis. The CD spectrum of the structured form is characteristic of parallel guanine tetraplexes. The structured form of the DNA sequence melts at approx. 47 °C in the presence of Na+ ions but the structure is stabilized up to 75 °C in the presence of K+ ions. The RNA structure is more stable than the equivalent DNA structure (melting temperature approx. 62 °C), and its stability is further enhanced in the presence of K+ ions. Two of the central guanine residues are fully protected from cleavage as determined by dimethyl sulphate protection experiments, whereas methylation interference studies show that methylation of any of the four central guanine residues inhibits structure formation. Our results demonstrate that the structured form of the nucleic acid is mediated through the formation of a guanine-tetraplex core region, in RNA this might be further stabilized by the presence of weaker uracil quartets.

Synthesis and Characterization of Platinum(IV) Anticancer Drugs with Functionalized Aromatic Carboxylate Ligands:  Influence of the Ligands on Drug Efficacies and Uptake

2005 ◽  
Vol 48 (25) ◽  
pp. 8060-8069 ◽  
Author(s):  
Wee Han Ang ◽  
Sébastien Pilet ◽  
Rosario Scopelliti ◽  
François Bussy ◽  
Lucienne Juillerat-Jeanneret ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Synthesis And Characterization ◽  
Carboxylate Ligands ◽  
Aromatic Carboxylate

Synthesis and characterization of new psoralen derivatives with superior photoreactivity with DNA and RNA

Biochemistry ◽  
1977 ◽  
Vol 16 (6) ◽  
pp. 1058-1064 ◽  
Author(s):  
Stephen T. Isaacs ◽  
Che-Kun James Shen ◽  
John E. Hearst ◽  
Henry Rapoport
Keyword(s):  
Synthesis And Characterization ◽  
Dna And Rna ◽  
Psoralen Derivatives

Designing, synthesis, and characterization of some novel coumarin derivatives as probable anticancer drugs

2012 ◽  
Vol 22 (9) ◽  
pp. 4146-4157 ◽  
Author(s):  
Darla Mark Manidhar ◽  
Rajesh Kumar Kesharwani ◽  
N. Bakthavatchala Reddy ◽  
C. Suresh Reddy ◽  
Krishna Misra
Keyword(s):  
Anticancer Drugs ◽  
Synthesis And Characterization ◽  
Coumarin Derivatives

Synthesis and characterization of dimethyl 6-bromo-2H-chromene-2,3-dicarboxylate: thermodynamic and kinetics investigations by computational and experimental studies

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 111239-111249 ◽  
Author(s):  
Osman Asheri ◽  
Sayyed Mostafa Habibi-Khorassani ◽  
Mehdi Shahraki
Keyword(s):  
Anticancer Drugs ◽  
Biological Activities ◽  
Experimental Studies ◽  
Modern Society ◽  
Synthesis And Characterization

Modern society is dependent on synthetic chromene derivatives for use as drugs, including anticancer drugs, and for their biological activities.

Synthesis and Characterization of the Three Dicyclopentapyrenes

1996 ◽  
Vol 61 (10) ◽  
pp. 3572-3572
Author(s):  
Lawrence T. Scott ◽  
Atena Necula
Keyword(s):  
Synthesis And Characterization
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