Design, Synthesis, and Biological Evaluation of 2,4-Diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors1

Aleem Gangjee; Xin Lin; Sherry F. Queener

doi:10.1021/jm0306327

Design, Synthesis, and Biological Evaluation of 2,4-Diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors1

Journal of Medicinal Chemistry ◽

10.1021/jm0306327 ◽

2004 ◽

Vol 47 (14) ◽

pp. 3689-3692 ◽

Cited By ~ 24

Author(s):

Aleem Gangjee ◽

Xin Lin ◽

Sherry F. Queener

Keyword(s):

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2018.04.035 ◽

2018 ◽

Vol 26 (9) ◽

pp. 2674-2685 ◽

Cited By ~ 3

Author(s):

Hao Li ◽

Fang Fang ◽

Yunqi Liu ◽

Liangmin Xue ◽

Meng Wang ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of 2,4-Diamino-6-methyl-5-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors.

ChemInform ◽

10.1002/chin.200541160 ◽

2005 ◽

Vol 36 (41) ◽

Author(s):

Aleem Gangjee ◽

Hiteshkumar D. Jain ◽

Sherry F. Queener

Keyword(s):

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01253 ◽

2017 ◽

Vol 60 (5) ◽

pp. 1734-1745 ◽

Cited By ~ 27

Author(s):

Hui-Li Ng ◽

Xiang Ma ◽

Eng-Hui Chew ◽

Wai-Keung Chui

Keyword(s):

Dihydrofolate Reductase ◽

Anticancer Agents ◽

Thioredoxin Reductase ◽

Biological Evaluation ◽

Design Synthesis ◽

Bioactive Scaffolds ◽

Dual Targeting ◽

Synthesis And Biological Evaluation

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Rational drug design, synthesis and biological evaluation of dihydrofolate reductase inhibitors as antituberculosis agents

Future Medicinal Chemistry ◽

10.4155/fmc.15.48 ◽

2015 ◽

Vol 7 (8) ◽

pp. 979-988 ◽

Cited By ~ 8

Author(s):

Nilesh R Tawari ◽

Seema Bag ◽

Archana Raju ◽

Arundhati C Lele ◽

Ranjeet Bairwa ◽

...

Keyword(s):

Drug Design ◽

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Rational Drug Design ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Rational Drug ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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ChemInform Abstract: Selective Pneumocystis carinii Dihydrofolate Reductase Inhibitors: Design, Synthesis, and Biological Evaluation of New 2,4-Diamino-5-substituted-furo[2,3-d]pyrimidines.

ChemInform ◽

10.1002/chin.199830172 ◽

2010 ◽

Vol 29 (30) ◽

pp. no-no

Author(s):

A. GANGJEE ◽

X. GUO ◽

S. F. QUEENER ◽

V. CODY ◽

N. GALITSKY ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Pneumocystis Carinii ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumor Agents: Design, Synthesis, and Biological Evaluation of Classical and Nonclassical Pyrrolo[2,3-d]pyrimidine Antifolates1

Journal of Medicinal Chemistry ◽

10.1021/jm058276a ◽

2006 ◽

Vol 49 (3) ◽

pp. 1055-1065 ◽

Cited By ~ 30

Author(s):

Aleem Gangjee ◽

Hiteshkumar D. Jain ◽

Jaclyn Phan ◽

Xin Lin ◽

Xiaohong Song ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Dual Inhibitors ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm701052u ◽

2008 ◽

Vol 51 (1) ◽

pp. 68-76 ◽

Cited By ~ 30

Author(s):

Aleem Gangjee ◽

Wei Li ◽

Jie Yang ◽

Roy L. Kisliuk

Keyword(s):

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.06.013 ◽

2019 ◽

Vol 178 ◽

pp. 329-340

Author(s):

Tianfeng Gao ◽

Congying Zhang ◽

Xiaowei Shi ◽

Ran Guo ◽

Kai Zhang ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Potential Antitumor

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Design, synthesis, and biological evaluation of novel N4-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

BMC Chemistry ◽

10.1186/s13065-019-0603-x ◽

2019 ◽

Vol 13 (1) ◽

Cited By ~ 6

Author(s):

Essam M. Hussein ◽

Munirah M. Al-Rooqi ◽

Shimaa M. Abd El-Galil ◽

Saleh A. Ahmed

Keyword(s):

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Design Synthesis ◽

Dhfr Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of 2,4-diamino-6-methyl-5-substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

Journal of Heterocyclic Chemistry ◽

10.1002/jhet.5570420418 ◽

2005 ◽

Vol 42 (4) ◽

pp. 589-594 ◽

Cited By ~ 7

Author(s):

Aleem Gangjee ◽

Hiteshkumar D. Jain ◽

Sherry F. Queener

Keyword(s):

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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