Identification of Compounds with Nanomolar Binding Affinity for Checkpoint Kinase-1 Using Knowledge-Based Virtual Screening

2004 ◽  
Vol 47 (8) ◽  
pp. 1962-1968 ◽  
Author(s):  
Paul D. Lyne ◽  
Peter W. Kenny ◽  
David A. Cosgrove ◽  
Chun Deng ◽  
Sonya Zabludoff ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Binding Affinity ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1 ◽  
Knowledge Based

scholarly journals Pharmacophore Modeling and Virtual Screening Studies of Checkpoint Kinase 1 Inhibitors

2009 ◽  
Vol 57 (7) ◽  
pp. 704-709 ◽  
Author(s):  
Jin-Juan Chen ◽  
Ting-Lin Liu ◽  
Li-Jun Yang ◽  
Lin-Li Li ◽  
Yu-Quan Wei ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Pharmacophore Modeling ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

scholarly journals Discovery of Novel Checkpoint Kinase 1 Inhibitors by Virtual Screening Based on Multiple Crystal Structures

2011 ◽  
Vol 51 (11) ◽  
pp. 2904-2914 ◽  
Author(s):  
Yan Li ◽  
Dong Joon Kim ◽  
Weiya Ma ◽  
Ronald A. Lubet ◽  
Ann M. Bode ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Crystal Structures ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

Adverse Cerebral Cardiovascular Events Associated with Checkpoint Kinase 1 Inhibitors

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Tongtong Yang ◽  
Jie Gu ◽  
Chong Du ◽  
Tiankai Shan ◽  
Tianwen Wei ◽  
...  
Keyword(s):  
Cardiovascular Events ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

scholarly journals Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition

Oncotarget ◽  
2017 ◽  
Vol 8 (56) ◽  
pp. 95206-95222 ◽  
Author(s):  
Stéphanie Arnould ◽  
Geneviève Rodier ◽  
Gisèle Matar ◽  
Charles Vincent ◽  
Nelly Pirot ◽  
...  
Keyword(s):  
Transformed Cells ◽  
Dihydroorotate Dehydrogenase ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

scholarly journals Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage

2016 ◽  
Vol 291 (25) ◽  
pp. 12951-12959 ◽  
Author(s):  
Xiangzi Han ◽  
Jinshan Tang ◽  
Jingna Wang ◽  
Feng Ren ◽  
Jinhua Zheng ◽  
...  
Keyword(s):  
Dna Damage ◽  
Conformational Change ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1
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