Exploring Structure−Activity Relationships of Transition State Analogues of Human Purine Nucleoside Phosphorylase

2003 ◽  
Vol 46 (15) ◽  
pp. 3412-3423 ◽  
Author(s):  
Gary B. Evans ◽  
Richard H. Furneaux ◽  
Andrzej Lewandowicz ◽  
Vern L. Schramm ◽  
Peter C. Tyler
Keyword(s):  
Transition State ◽  
Purine Nucleoside Phosphorylase ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Transition State Analogues

Structure−Activity Relationships for a Class of Inhibitors of Purine Nucleoside Phosphorylase

1999 ◽  
Vol 42 (13) ◽  
pp. 2422-2431 ◽  
Author(s):  
Victor Farutin ◽  
Lori Masterson ◽  
Adriano D. Andricopulo ◽  
Jianming Cheng ◽  
Brad Riley ◽  
...  
Keyword(s):  
Purine Nucleoside Phosphorylase ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Conformational States of Human Purine Nucleoside Phosphorylase at Rest, at Work, and with Transition State Analogues

Biochemistry ◽  
2010 ◽  
Vol 49 (9) ◽  
pp. 2058-2067 ◽  
Author(s):  
Achelle A. Edwards ◽  
Jeremiah D. Tipton ◽  
Michael D. Brenowitz ◽  
Mark R. Emmett ◽  
Alan G. Marshall ◽  
...  
Keyword(s):  
Transition State ◽  
Purine Nucleoside Phosphorylase ◽  
Purine Nucleoside ◽  
Conformational States ◽  
Nucleoside Phosphorylase ◽  
Transition State Analogues

scholarly journals Altered Enthalpy−Entropy Compensation in Picomolar Transition State Analogues of Human Purine Nucleoside Phosphorylase

Biochemistry ◽  
2009 ◽  
Vol 48 (23) ◽  
pp. 5226-5238 ◽  
Author(s):  
Achelle A. Edwards ◽  
Jennifer M. Mason ◽  
Keith Clinch ◽  
Peter C. Tyler ◽  
Gary B. Evans ◽  
...  
Keyword(s):  
Transition State ◽  
Purine Nucleoside Phosphorylase ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
Transition State Analogues
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