N-ArylN‘-Hydroxyguanidines, A New Class of NO-Donors after Selective Oxidation by Nitric Oxide Synthases:  Structure−Activity Relationship

2002 ◽  
Vol 45 (4) ◽  
pp. 944-954 ◽  
Author(s):  
Axelle Renodon-Cornière ◽  
Sylvie Dijols ◽  
Céline Perollier ◽  
David Lefevre-Groboillot ◽  
Jean-Luc Boucher ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Selective Oxidation ◽  
Structure Activity Relationship ◽  
Nitric Oxide Synthases ◽  
Activity Relationship ◽  
No Donors ◽  
New Class ◽  
Structure Activity

Structure–activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists

2005 ◽  
Vol 15 (3) ◽  
pp. 527-530 ◽  
Author(s):  
Michel Belley ◽  
Michel Gallant ◽  
Bruno Roy ◽  
Karine Houde ◽  
Nicolas Lachance ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Cinnamic Acids ◽  
New Class ◽  
Structure Activity

Structure-activity relationship of the inhibitory effects of flavonoids on nitric oxide production in RAW264.7 cells

2017 ◽  
Vol 25 (2) ◽  
pp. 779-788 ◽  
Author(s):  
Wen-Jun Jiang ◽  
Akihiro Daikonya ◽  
Mitsuyoshi Ohkawara ◽  
Takashi Nemoto ◽  
Ryusuke Noritake ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Raw264.7 Cells ◽  
Nitric Oxide Production ◽  
Inhibitory Effects ◽  
Oxide Production ◽  
Structure Activity ◽  
Relationship Of

Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents

2019 ◽  
Vol 15 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Elda Meta ◽  
Chiara Brullo ◽  
Michele Tonelli ◽  
Scott G. Franzblau ◽  
Yuehong Wang ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyrazole Derivatives ◽  
Antitubercular Agents ◽  
Active Compounds ◽  
Protein Targets ◽  
Preliminary Screening ◽  
New Class ◽  
Structure Activity ◽  
Starting Point

Background: We screened a large library of differently decorated imidazo-pyrazole and pyrazole derivatives as possible new antitubercular agents and this preliminary screening showed that many compounds are able to totally inhibit Mycobacterium growth (>90 %). Among the most active compounds, we selected some new possible hits based on their similarities and, at the same time, on their novelty with respect to the pipeline drugs. </P><P> Methods: In order to increase the potency and obtain more information about structure-activity relationship (SAR), we designed and synthesized three new series of compounds (2a–e, 3a–e, and 4a–l). Conclusion: Performed tests confirmed that both new pyrazoles and imidazo-pyrazoles could represent a new starting point to obtain more potent compounds and further work is now underway to identify the protein targets of this new class of anti-TB agents.

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