N-substituted hydroxynaphthalene imino-oxindole derivatives as new class of PI3-kinase inhibitor and breast cancer drug: Molecular validation and structure-activity relationship studies

M. Rajesh Kumar; Manikandan Alagumuthu; V. Violet Dhayabaran

doi:10.1111/cbdd.13079

N-substituted hydroxynaphthalene imino-oxindole derivatives as new class of PI3-kinase inhibitor and breast cancer drug: Molecular validation and structure-activity relationship studies

Chemical Biology & Drug Design ◽

10.1111/cbdd.13079 ◽

2017 ◽

Vol 91 (1) ◽

pp. 277-284 ◽

Cited By ~ 12

Author(s):

M. Rajesh Kumar ◽

Manikandan Alagumuthu ◽

V. Violet Dhayabaran

Keyword(s):

Breast Cancer ◽

Kinase Inhibitor ◽

Structure Activity Relationship ◽

Pi3 Kinase ◽

Activity Relationship ◽

Cancer Drug ◽

New Class ◽

Structure Activity

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Design, Synthesis, and Structure–Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b00270 ◽

2015 ◽

Vol 58 (9) ◽

pp. 3957-3974 ◽

Cited By ~ 26

Author(s):

Chun-Hui Zhang ◽

Ming-Wu Zheng ◽

Ya-Ping Li ◽

Xing-Dong Lin ◽

Mei Huang ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

New Class ◽

Structure Activity

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Faculty Opinions recommendation of 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1085984.538933 ◽

2007 ◽

Author(s):

Andrew Combs

Keyword(s):

Kinase Inhibitor ◽

Src Kinase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Template Structure

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Anticancer agents based on Plastoquinone analogs with N-phenylpiperazine: Structure-activity relationship and mechanism of action in breast cancer cells

Chemico-Biological Interactions ◽

10.1016/j.cbi.2021.109673 ◽

2021 ◽

pp. 109673

Author(s):

Ayse Tarbin Jannuzzi ◽

Mahmut Yıldız ◽

Nilüfer Bayrak ◽

Hatice Yıldırım ◽

Deepak Shilkar ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Mechanism Of Action ◽

Anticancer Agents ◽

Breast Cancer Cells ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity

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Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112842 ◽

2021 ◽

Vol 209 ◽

pp. 112842

Author(s):

Wei Yang ◽

Xiaolong Liu ◽

Chunli Song ◽

Sen Ji ◽

Jianhong Yang ◽

...

Keyword(s):

Ischemic Stroke ◽

Therapeutic Effect ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Stroke Model ◽

Phenothiazine Derivatives ◽

New Class ◽

Structure Activity

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Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide

Bioorganic Chemistry ◽

10.1016/j.bioorg.2020.103717 ◽

2020 ◽

Vol 98 ◽

pp. 103717 ◽

Cited By ~ 1

Author(s):

Maciej Dawidowski ◽

Marek Król ◽

Bartłomiej Szulczyk ◽

Andrzej Chodkowski ◽

Piotr Podsadni ◽

...

Keyword(s):

Broad Spectrum ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Cardiac Safety ◽

New Class ◽

Structure Activity

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Abstract P6-02-09: Structure-activity relationship of ruthenium (Ru) complexes to inhibit breast cancer growth and metastasis

10.1158/1538-7445.sabcs14-p6-02-09 ◽

2015 ◽

Author(s):

Joji Iida ◽

Marc L Prazo ◽

Yifeng Lu ◽

Elisabeth T Bell-Loncella ◽

Craig D Shriver

Keyword(s):

Breast Cancer ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Cancer Growth ◽

Structure Activity ◽

Ru Complexes ◽

Breast Cancer Growth ◽

Relationship Of

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Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112866 ◽

2021 ◽

Vol 209 ◽

pp. 112866

Author(s):

Md Ashraf-Uz-Zaman ◽

Sadisna Shahi ◽

Racheal Akwii ◽

Md Sanaullah Sajib ◽

Mohammad Jodeiri Farshbaf ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study ◽

Urea Compounds

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Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.06.004 ◽

2019 ◽

Vol 178 ◽

pp. 589-605 ◽

Cited By ~ 1

Author(s):

Gang Liu ◽

Tao Yin ◽

Hyejin Kim ◽

Chunyong Ding ◽

Zhuo Yu ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Er Positive

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Urea−PETT Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 3. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogues

Journal of Medicinal Chemistry ◽

10.1021/jm990095j ◽

1999 ◽

Vol 42 (20) ◽

pp. 4150-4160 ◽

Cited By ~ 47

Author(s):

Marita Högberg ◽

Christer Sahlberg ◽

Per Engelhardt ◽

Rolf Noréen ◽

Jussi Kangasmetsä ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

New Class ◽

Structure Activity ◽

Hiv 1

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Identification and structure–activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.10.021 ◽

2010 ◽

Vol 20 (23) ◽

pp. 6895-6898 ◽

Cited By ~ 21

Author(s):

Sabina Pecchi ◽

Paul A. Renhowe ◽

Clarke Taylor ◽

Susan Kaufman ◽

Hanne Merritt ◽

...

Keyword(s):

Kinase Inhibitors ◽

Structure Activity Relationship ◽

Pi3 Kinase ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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