Covalently Induced Activation of the δ Opioid Receptor by a Fluorogenic Affinity Label, 7‘-(Phthalaldehydecarboxamido)naltrindole (PNTI)

2001 ◽  
Vol 44 (7) ◽  
pp. 1017-1020 ◽  
Author(s):  
Bertrand Le Bourdonnec ◽  
Rachid El Kouhen ◽  
Gennady Poda ◽  
Ping Y. Law ◽  
Horace H. Loh ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Affinity Label ◽  
Δ Opioid Receptor

o-Naphthalenedicarboxaldehyde Derivative of 7‘-Aminonaltrindole as a Selective δ-Opioid Receptor Affinity Label

2007 ◽  
Vol 50 (14) ◽  
pp. 3392-3396 ◽  
Author(s):  
Sarika Prabhu Haris ◽  
Yan Zhang ◽  
Bertrand Le Bourdonnec ◽  
Christopher R. McCurdy ◽  
Philip S. Portoghese
Keyword(s):  
Opioid Receptor ◽  
Receptor Affinity ◽  
Affinity Label ◽  
Δ Opioid Receptor

ENKEPHALIN-INDUCED DESENSITIZATION OF ADENYLATE CYCLASE IN RECOMBINANT CV CELLS EXPRESSING A MOUSE δ-OPIOID RECEPTOR

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 603-606
Author(s):  
Vincent Nappey ◽  
Jean-luc Butour ◽  
Christiane Moisand ◽  
Claire Gaveriaux-Ruff ◽  
Brigitte Kieffer ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Opioid Receptor ◽  
Δ Opioid Receptor

Genetic Variation in δ-Opioid Receptor Associates with Increased β- and γ-Secretase Activity in the Late Stages of Alzheimer’s Disease

2015 ◽  
Vol 48 (2) ◽  
pp. 507-516 ◽  
Author(s):  
Timo Sarajärvi ◽  
Mikael Marttinen ◽  
Teemu Natunen ◽  
Tarja Kauppinen ◽  
Petra Mäkinen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Variation ◽  
Opioid Receptor ◽  
Secretase Activity ◽  
Δ Opioid Receptor ◽  
Late Stages

The K+-evoked release of [3H]acetylcholine from slices of rat globus pallidus: modulation by δ-opioid receptors

1991 ◽  
Vol 69 (3) ◽  
pp. 414-418 ◽  
Author(s):  
Bianca B. Ruzicka ◽  
Khem Jhamandas
Keyword(s):  
Globus Pallidus ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Cholinergic Neurons ◽  
Receptor Activation ◽  
Inhibitory Effect ◽  
Dependent Manner ◽  
Release Of Acetylcholine ◽  
Δ Opioid Receptor ◽  
Tritium Release

Previous investigations have shown that the activation of δ-opioid receptors depresses the release of acetylcholine (ACh) in the rat caudate putamen. This finding raised the possibility that the release of ACh is similarly modulated in the globus pallidus, a region containing a distinct population of cholinergic neurons and enriched in enkephalinergic nerve terminals. In the present study the pallidal release of ACh was characterized and the effects of δ-opioid receptor activation on this release were examined. The results show that this release is stimulated by high K+ in a concentration- and Ca2+-dependent manner. D-Pen2,L-Pen5-enkephalin (0.1 – 10 μM), a selective δ-opioid receptor agonist, produced a dose-related inhibition of the 25 mM K+-evoked tritium release. The maximal inhibitory effect, representing a 34% decrease in the K+-induced tritium release, was observed at a concentration of 1 μM. This opioid effect was attenuated by the selective δ-opioid receptor antagonist, ICI 174864 (1 μM). These findings support the role of a δ-opioid receptor in the modulation of ACh release in the rat globus pallidus.Key words: globus pallidus, acetylcholine, enkephalin, release.

Age-related emotionality is associated with cortical δ-opioid receptor dysfunction-dependent astrogliosis

Neuroscience ◽  
2006 ◽  
Vol 137 (4) ◽  
pp. 1359-1367 ◽  
Author(s):  
M. Narita ◽  
N. Kuzumaki ◽  
M. Narita ◽  
C. Kaneko ◽  
E. Tamai ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Age Related ◽  
Δ Opioid Receptor
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