Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters

1987 ◽  
Vol 30 (4) ◽  
pp. 635-640 ◽  
Author(s):  
Karnail S. Atwal ◽  
James L. Bergey ◽  
Anders Hedberg ◽  
Suzanne Moreland
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Acid Esters

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

1992 ◽  
Vol 35 (17) ◽  
pp. 3254-3263 ◽  
Author(s):  
George C. Rovnyak ◽  
Karnail S. Atwal ◽  
Anders Hedberg ◽  
S. David Kimball ◽  
Suzanne Moreland ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Acid Esters

Dihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

1990 ◽  
Vol 33 (9) ◽  
pp. 2629-2635 ◽  
Author(s):  
Karnail S. Atwal ◽  
George C. Rovnyak ◽  
S. David Kimball ◽  
David M. Floyd ◽  
Suzanne Moreland ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Acid Esters

Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

1991 ◽  
Vol 34 (2) ◽  
pp. 806-811 ◽  
Author(s):  
Karnail S. Atwal ◽  
Brian N. Swanson ◽  
Steven E. Unger ◽  
David M. Floyd ◽  
Suzanne Moreland ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Acid Esters

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

1990 ◽  
Vol 33 (5) ◽  
pp. 1510-1515 ◽  
Author(s):  
Karnail S. Atwal ◽  
George C. Rovnyak ◽  
Joseph Schwartz ◽  
Suzanne Moreland ◽  
Anders Hedberg ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Acid Esters

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

1999 ◽  
Vol 9 (16) ◽  
pp. 2447-2452 ◽  
Author(s):  
Robert M. Schelkun ◽  
Po-wai Yuen ◽  
Thomas C. Malone ◽  
David M. Rock ◽  
Sally Stoehr ◽  
...  
Keyword(s):  
Biological Activity ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers

Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives

2012 ◽  
Vol 22 (11) ◽  
pp. 3639-3642 ◽  
Author(s):  
Takashi Yamamoto ◽  
Seiji Niwa ◽  
Munetaka Tokumasu ◽  
Tomoyuki Onishi ◽  
Seiji Ohno ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers
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