Synthetic and enzyme inhibition studies of pepstatin analogs containing hydroxyethylene and ketomethylene dipeptide isosteres

1987 ◽  
Vol 30 (2) ◽  
pp. 374-383 ◽  
Author(s):  
Mark W. Holladay ◽  
Francesco G. Salituro ◽  
Daniel H. Rich
Keyword(s):  
Enzyme Inhibition ◽  
Inhibition Studies

Mycobacterial DNA GyrB Inhibitors: Ligand Based Pharmacophore Modelling and In Vitro Enzyme Inhibition Studies

2014 ◽  
Vol 14 (17) ◽  
pp. 1990-2005 ◽  
Author(s):  
Shalini Saxena ◽  
Janupally Renuka ◽  
Variam Jeankumar ◽  
Perumal Yogeeswari ◽  
Dharmarajan Sriram
Keyword(s):  
Enzyme Inhibition ◽  
Pharmacophore Modelling ◽  
Inhibition Studies

scholarly journals Synthesis, Spectral and Enzyme Inhibition Studies on N-Aralkyl/ Aryl Sulfonated Derivatives of Commercially Available Paroxetine

2014 ◽  
Vol 26 (1) ◽  
pp. 93-98
Author(s):  
Asia Siddiqa ◽  
Aziz-ur-Rehman ◽  
Muhammad Athar Abbasi ◽  
Shahid Rasool ◽  
Ghulam Hussain ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Inhibition Studies ◽  
Derivatives Of

Isolation and Enzyme-Inhibition Studies of the Chemical Constituents fromAjuga bracteosa

2007 ◽  
Vol 4 (1) ◽  
pp. 72-83 ◽  
Author(s):  
Naheed Riaz ◽  
Sarfraz A. Nawaz ◽  
Naveen Mukhtar ◽  
Abdul Malik ◽  
Nighat Afza ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Chemical Constituents ◽  
Inhibition Studies

scholarly journals Phytochemical Composition and Enzyme Inhibition Studies of Buxus papillosa C.K. Schneid

Processes ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 757
Author(s):  
Hammad Saleem ◽  
Thet Thet Htar ◽  
Rakesh Naidu ◽  
Gokhan Zengin ◽  
Marcello Locatelli ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Skin Diseases ◽  
Research Work ◽  
Tentative Identification ◽  
Chemical Profiling ◽  
Phytochemical Composition ◽  
In Vitro Bioassays ◽  
Inhibition Studies ◽  
Wide Usage

The current research work is an endeavor to study the chemical profiling and enzyme-inhibition potential of different polarity solvent (n-hexane, dichloromethane—DCM and methanol—MeOH) extracts from the aerial and stem parts of Buxus papillosa C.K. Schneid. All the extracts were analyzed for HPLC-PDA phenolic quantification, while both (aerial and stem) DCM extracts were studied for UHPLC-MS phytochemical composition. The inhibitory activity against the clinically important enzymes having crucial role in different pathologies like skin diseases (tyrosinase), inflammatory problems (lipoxygenase—LOX) and diabetes mellitus (α-amylase) were studied using standard in vitro bioassays. The DCM extracts upon UHPLC-MS analysis conducted in both negative and positive ionization modes has led to the tentative identification of 52 important secondary metabolites. Most of these belonged to the alkaloid, flavonoid, phenolic and triterpenoid classes. The HPLC-PDA polyphenolic quantification identified the presence of 10 phenolic compounds. Catechin was present in significant amounts in aerial-MeOH (7.62 ± 0.45 μg/g extract) and aerial-DCM (2.39 ± 0.51-μg/g extract) extracts. Similarly, higher amounts of epicatechin (2.76 ± 0.32-μg/g extract) and p-hydroxybenzoic acid (1.06 ± 0.21 μg/g extract) were quantified in aerial-DCM and stem-MeOH extracts, respectively. Likewise, all the extracts exhibited moderate inhibition against all the tested enzymes. These findings explain the wide usage of this plant in folklore medicine and suggest that it could be further studied as an origin of novel bioactive phytocompounds and for the designing of new pharmaceuticals.

ENZYME INHIBITION STUDIES WITH DICHLOROBENZOPRIM: A NOVEL LIPOPHILIC ANTIFOLATE

1990 ◽  
Vol 42 (S1) ◽  
pp. 95P-95P
Author(s):  
R J Griffin ◽  
M F G Stevens ◽  
P A Lambert
Keyword(s):  
Enzyme Inhibition ◽  
Inhibition Studies

Synthesis, crystal structures, antimicrobial properties and enzyme inhibition studies of zinc(II) complexes of thiones

2011 ◽  
Vol 376 (1) ◽  
pp. 207-211 ◽  
Author(s):  
Muhammad Riaz Malik ◽  
Vera Vasylyeva ◽  
Klaus Merz ◽  
Nils Metzler-Nolte ◽  
Muhammad Saleem ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Enzyme Inhibition ◽  
Antimicrobial Properties ◽  
Inhibition Studies

Antibacterial and Enzyme Inhibition Studies of N'-Substituted Benzylidene-2-(2, 4- Dimethylphenoxy) Acetatohydrazides

2014 ◽  
Vol 4 (3) ◽  
pp. 96-100
Author(s):  
Aziz-ur-Rehman ◽  
S. Nadeem ◽  
M. A. Abbasi ◽  
S. Z. Siddiqui ◽  
S. Rasool ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Inhibition Studies

Sequence-Selective Interaction of the Minor-Groove Interstrand Cross-Linking Agent SJG-136 with Naked and Cellular DNA:  Footprinting and Enzyme Inhibition Studies†

Biochemistry ◽  
2005 ◽  
Vol 44 (11) ◽  
pp. 4135-4147 ◽  
Author(s):  
Chris Martin ◽  
Tom Ellis ◽  
Claire J. McGurk ◽  
Terence C. Jenkins ◽  
John A. Hartley ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Minor Groove ◽  
Cross Linking ◽  
Dna Footprinting ◽  
Selective Interaction ◽  
Cellular Dna ◽  
Inhibition Studies
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