Carboxyimamidate, a low-molecular-weight polyelectrolyte with antitumor properties and low toxicity

1982 ◽  
Vol 25 (9) ◽  
pp. 1060-1064 ◽  
Author(s):  
Joseph E. Fields ◽  
Samuel S. Asculai ◽  
John H. Johnson ◽  
Randall K. Johnson
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Low Toxicity ◽  
Antitumor Properties

Dihalogen and Solvent-Free Preparation of syn-Bimane

Synlett ◽  
2018 ◽  
Vol 29 (08) ◽  
pp. 1043-1046 ◽  
Author(s):  
Flavio Grynszpan ◽  
Ishita Neogi ◽  
Partha Das
Keyword(s):  
Molecular Weight ◽  
Molecular Probes ◽  
Solvent Free ◽  
Low Molecular Weight ◽  
Laser Dyes ◽  
Practical Applications ◽  
Chlorine Gas ◽  
Low Toxicity

Fluorescent bimanes are low molecular weight and low toxicity molecules with applications ranging from biology to LASER dyes. The widespread use of these molecular probes has presumably been stalled by the hazards involved in their current synthetic preparation which involve handling of dangerous halogens like chlorine (gas) and bromine (liq.). The accessibility achieved by the simple and safe dihalogen and solvent-free methodologies described here open the floodgates to additional future practical applications of bimanes.

A Biodegradable Low Molecular Weight Polyethylenimine Derivative as Low Toxicity and Efficient Gene Vector

2009 ◽  
Vol 20 (2) ◽  
pp. 322-332 ◽  
Author(s):  
Yuting Wen ◽  
Shirong Pan ◽  
Xin Luo ◽  
Xuan Zhang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Gene Vector ◽  
Efficient Gene ◽  
Low Toxicity

A core–shell structured polyplex for efficient and non-toxic gene delivery

2017 ◽  
Vol 5 (26) ◽  
pp. 5101-5108 ◽  
Author(s):  
Saisai Wang ◽  
Fei Wang ◽  
Qiang Zhang ◽  
Yiyun Cheng
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Core Shell ◽  
Low Molecular Weight ◽  
The Core ◽  
Transfection Efficacy ◽  
Toxic Gene ◽  
Low Toxicity ◽  
Linear Polyethylenimine

We developed a core–shell polyplex with minimal high generation dendrimer to condense DNA and low-molecular-weight linear polyethylenimine coated on the core. The polyplex represented both high transfection efficacy and low toxicity.

An apoptosis-homing peptide-conjugated low molecular weight heparin-taurocholate conjugate with antitumor properties

Biomaterials ◽  
2013 ◽  
Vol 34 (8) ◽  
pp. 2077-2086 ◽  
Author(s):  
Sang Mun Bae ◽  
Jong-Ho Kim ◽  
Seung Woo Chung ◽  
Youngro Byun ◽  
Sang Yoon Kim ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Antitumor Properties ◽  
Homing Peptide

scholarly journals Peptide-Based Treatment: A Promising Cancer Therapy

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Yu-Feng Xiao ◽  
Meng-Meng Jie ◽  
Bo-Sheng Li ◽  
Chang-Jiang Hu ◽  
Rui Xie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Overall Survival ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Low Molecular Weight ◽  
Peptide Vaccines ◽  
Normal Tissues ◽  
New Methods ◽  
Low Toxicity

Many new therapies are currently being used to treat cancer. Among these new methods, chemotherapy based on peptides has been of great interest due to the unique advantages of peptides, such as a low molecular weight, the ability to specifically target tumor cells, and low toxicity in normal tissues. In treating cancer, peptide-based chemotherapy can be mainly divided into three types, peptide-alone therapy, peptide vaccines, and peptide-conjugated nanomaterials. Peptide-alone therapy may specifically enhance the immune system’s response to kill tumor cells. Peptide-based vaccines have been used in advanced cancers to improve patients’ overall survival. Additionally, the combination of peptides with nanomaterials expands the therapeutic ability of peptides to treat cancer by enhancing drug delivery and sensitivity. In this review, we mainly focus on the new advances in the application of peptides in treating cancer in recent years, including diagnosis, treatment, and prognosis.

A high-performance oil-free backing pump for electron microscopes

1978 ◽  
Vol 36 (1) ◽  
pp. 110-111
Author(s):  
G.K.W. Balkau ◽  
E. Bez ◽  
J.L. Farrant
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Hot Spots ◽  
High Performance ◽  
Carbonaceous Material ◽  
Contamination Rate ◽  
Low Molecular Weight ◽  
Principal Source ◽  
Rotary Pumps ◽  
Electron Microscopes

The earliest account of the contamination of electron microscope specimens by the deposition of carbonaceous material during electron irradiation was published in 1947 by Watson who was then working in Canada. It was soon established that this carbonaceous material is formed from organic vapours, and it is now recognized that the principal source is the oil-sealed rotary pumps which provide the backing vacuum. It has been shown that the organic vapours consist of low molecular weight fragments of oil molecules which have been degraded at hot spots produced by friction between the vanes and the surfaces on which they slide. As satisfactory oil-free pumps are unavailable, it is standard electron microscope practice to reduce the partial pressure of organic vapours in the microscope in the vicinity of the specimen by using liquid-nitrogen cooled anti-contamination devices. Traps of this type are sufficient to reduce the contamination rate to about 0.1 Å per min, which is tolerable for many investigations.

Low-molecular-weight heparin in the prevention and treatment of thromboembolic disorders

1998 ◽  
Vol 1 (5) ◽  
pp. 166-174 ◽  
Author(s):  
Evelyn R Hermes De Santis ◽  
Betsy S Laumeister ◽  
Vidhu Bansal ◽  
Vandana Kataria ◽  
Preeti Loomba ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Prevention And Treatment
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