Metal complexes of 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone) and related ligands as antitumor agents

1968 ◽  
Vol 11 (4) ◽  
pp. 695-699 ◽  
Author(s):  
G. J. Van Giessen ◽  
H. G. Petering
Keyword(s):  
Metal Complexes ◽  
Antitumor Agents

scholarly journals Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3492
Author(s):  
Katarzyna Gałczyńska ◽  
Zuzanna Drulis-Kawa ◽  
Michał Arabski
Keyword(s):  
Cell Cycle ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Antitumor Agents ◽  
Current Knowledge ◽  
Biological Activities ◽  
Chemical Compounds ◽  
Cell Cycle Inhibition ◽  
Therapeutic Compounds

Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review.

scholarly journals MN4-based G4-Ligands as Potential Antitumor Agents: A Review

2021 ◽  
Vol 12 (3) ◽  
pp. 3977-3988
Keyword(s):  
Metal Complexes ◽  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Genomic Dna ◽  
Rational Design ◽  
Structural Engineering ◽  
Antitumor Agents ◽  
Medical Field ◽  
G Quadruplex ◽  
Potential Antitumor

Cisplatin-based metal drugs have been widely used clinically as anticancer agents. However, these drugs also harm ordinary tissues because cisplatin kills cancer cells by attacking genomic DNA. Therefore, it has been shown that cisplatin-based metal drugs have some serious side effects that cannot be avoided. In order to replace the target site of genomic DNA, G-quadruplex nucleic acid is considered to be an alternative and attractive target for anticancer agents because G-quadruplex always folds into a parallel topology and is, therefore, more important than DNA. This review discussed the recent advancements in the rational design and the development of metal complexes containing anticancer drugs to interact and stabilize or cleave the G4 structure selectively. Further, we also highlighted the G4-interacting transition metal complexes, interacting modes, and their potentials to serve as anticancer drugs in the medical field. The significance of this survey lies in designing the metallodrugs from the most fundamental characteristic of electronic structural engineering to an increasingly reasonable dimension of bio-science.

Metal Complexes of Natural Product Like-compounds with Antitumor Activity

2019 ◽  
Vol 19 (1) ◽  
pp. 48-65 ◽  
Author(s):  
Beatriz L. Heras ◽  
Ángel Amesty ◽  
Ana Estévez-Braun ◽  
Sonsoles Hortelano
Keyword(s):  
Metal Complexes ◽  
Natural Product ◽  
Active Sites ◽  
Rational Design ◽  
Complex Disease ◽  
Antitumor Agents ◽  
Research Activity ◽  
Drug Molecules ◽  
Starting Point ◽  
Negative Side Effects

Cancer continues to be one of the major causes of death worldwide. Despite many advances in the understanding of this complex disease, new approaches are needed to improve the efficacy of current therapeutic treatments against aggressive tumors. Natural products are one of the most consistently successful sources of drug leads. In recent decades, research activity into the clinical potential of this class of compounds in cancer has increased. Furthermore, a highly promising field is the use of metals and their complexes in the design and development of metal-based drugs for the treatment of cancer. Metal complexes offer unique opportunities due to their ability to alter pharmacology, improving the efficacy and/or reducing the negative side effects of drug molecules. In addition, transition metals as copper, iron, and manganese, among others, can interact with active sites of enzymes, playing important roles in multiple biological processes. Thus, these complexes not only possess higher activities but also reach their targets more efficiently. This review article highlights recent advances on the emerging and expanding field of metal-based drugs. The emphasis is on new therapeutic strategies consisting of metal complexes with natural product like-compounds as a starting point for the rational design of new antitumor agents.

scholarly journals Rhenium(I) Complexes with Pincer Ligands as a New Class of Potential Antitumor Agents

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 43
Author(s):  
Diana V. Aleksanyan ◽  
Svetlana G. Churusova ◽  
Ekaterina Yu. Rybalkina ◽  
Vladimir A. Kozlov
Keyword(s):  
Metal Complexes ◽  
Antitumor Agents ◽  
Solid Phase ◽  
Organometallic Compounds ◽  
Chemotherapeutic Agents ◽  
Palladium Complexes ◽  
Pincer Ligands ◽  
New Class ◽  
Solvent Free Conditions ◽  
Potential Antitumor

Transition metal complexes attract continuous research interest as potential antitumor agents. The most popular compounds are ruthenium, gold, titanium, osmium, iridium, zinc, and palladium complexes, which have already displayed cytotoxic features that are not typical for classical platinum-containing chemotherapeutic agents. Substantially lower attention is drawn to organometallic compounds of rhenium. However, the known examples of cytotoxic organometallic rhenium derivatives with bidentate heterocyclic, organophosphorus, labile alkoxide, and hydroxide ligands render further studies in this field very promising. As for their analogs with multidentate ligands, a literature survey has revealed only a few examples of cytotoxic rhenium complexes, whereas the antitumor activity of cyclometallated derivatives has not been studied at all. At the same time, it is known that the use of pincer-type ligands having specific tridentate monoanionic frameworks, which offer multiple options for directed structural modifications, allows one to finely tune the thermodynamic and kinetic stability of the resulting metal complexes. Therefore, we synthesized and studied the cytotoxic properties of a series of rhenium(I) complexes with tridentate pincer-type ligands based on functionalized carboxamides bearing ancillary donor groups both in the acid and amine components. It was shown that the target complexes can be obtained not only by the conventional solution-based method, but also under solvent-free conditions according to the solid-phase methodology recently developed in our group. The results obtained were used to define the main structure–activity relationships for a principally new class of potential antitumor agents and to choose the most promising compounds for further studies in order to create new pharmaceuticals.

scholarly journals A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

2021 ◽  
Vol 11 (13) ◽  
pp. 6027
Author(s):  
Alessia Catalano ◽  
Maria Stefania Sinicropi ◽  
Domenico Iacopetta ◽  
Jessica Ceramella ◽  
Annaluisa Mariconda ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Schiff Bases ◽  
Anticancer Agents ◽  
Essential Role ◽  
Antitumor Agents ◽  
Biological Activities ◽  
Low Cost ◽  
Oxidation States ◽  
Pharmaceutical Sciences ◽  
Antiproliferative Agents

Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.

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