Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards

1993 ◽  
Vol 36 (13) ◽  
pp. 1839-1846 ◽  
Author(s):  
David C. Ware ◽  
Brian D. Palmer ◽  
William R. Wilson ◽  
William A. Denny
Keyword(s):  
Metal Complexes ◽  
Antitumor Agents ◽  
New Class

scholarly journals Rhenium(I) Complexes with Pincer Ligands as a New Class of Potential Antitumor Agents

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 43
Author(s):  
Diana V. Aleksanyan ◽  
Svetlana G. Churusova ◽  
Ekaterina Yu. Rybalkina ◽  
Vladimir A. Kozlov
Keyword(s):  
Metal Complexes ◽  
Antitumor Agents ◽  
Solid Phase ◽  
Organometallic Compounds ◽  
Chemotherapeutic Agents ◽  
Palladium Complexes ◽  
Pincer Ligands ◽  
New Class ◽  
Solvent Free Conditions ◽  
Potential Antitumor

Transition metal complexes attract continuous research interest as potential antitumor agents. The most popular compounds are ruthenium, gold, titanium, osmium, iridium, zinc, and palladium complexes, which have already displayed cytotoxic features that are not typical for classical platinum-containing chemotherapeutic agents. Substantially lower attention is drawn to organometallic compounds of rhenium. However, the known examples of cytotoxic organometallic rhenium derivatives with bidentate heterocyclic, organophosphorus, labile alkoxide, and hydroxide ligands render further studies in this field very promising. As for their analogs with multidentate ligands, a literature survey has revealed only a few examples of cytotoxic rhenium complexes, whereas the antitumor activity of cyclometallated derivatives has not been studied at all. At the same time, it is known that the use of pincer-type ligands having specific tridentate monoanionic frameworks, which offer multiple options for directed structural modifications, allows one to finely tune the thermodynamic and kinetic stability of the resulting metal complexes. Therefore, we synthesized and studied the cytotoxic properties of a series of rhenium(I) complexes with tridentate pincer-type ligands based on functionalized carboxamides bearing ancillary donor groups both in the acid and amine components. It was shown that the target complexes can be obtained not only by the conventional solution-based method, but also under solvent-free conditions according to the solid-phase methodology recently developed in our group. The results obtained were used to define the main structure–activity relationships for a principally new class of potential antitumor agents and to choose the most promising compounds for further studies in order to create new pharmaceuticals.

Mechanochemical changes on cyclometalated Ir(iii) acyclic carbene complexes – design and tuning of luminescent mechanochromic transition metal complexes

2020 ◽  
Vol 7 (3) ◽  
pp. 786-794 ◽  
Author(s):  
Jingqi Han ◽  
Kin-Man Tang ◽  
Shun-Cheung Cheng ◽  
Chi-On Ng ◽  
Yuen-Kiu Chun ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Carbene Complexes ◽  
New Class

A new class of luminescent cyclometalated Ir(iii) complexes with readily tunable mechanochromic properties derived from the mechanically induced trans-to-cis isomerization have been developed.

Synthesis, characterization, and antiproliferative and apoptosis inducing effects of novels-triazine derivatives

2018 ◽  
Vol 42 (3) ◽  
pp. 1698-1714 ◽  
Author(s):  
Mani Shanmugam ◽  
Kuppusamy Narayanan ◽  
Kamatam Hari Prasad ◽  
Dhanapalan Karthikeyan ◽  
Loganathan Chandrasekaran ◽  
...  
Keyword(s):  
Schiff Base ◽  
Nucleophilic Substitution ◽  
Antitumor Agents ◽  
New Class ◽  
Schiff Base Derivatives ◽  
Triazine Derivatives

In an attempt to design and synthesize a new class of antitumor agents, a mild and eco-friendly protocol for nucleophilic substitution using ans-triazine scaffold,viaamine and Schiff base derivatives, has been developed.

scholarly journals Pyridine-2,6-Dithiocarboxylic Acid and Its Metal Complexes: New Inhibitors of New Delhi Metallo -Lactamase-1

Marine Drugs ◽  
2020 ◽  
Vol 18 (6) ◽  
pp. 295
Author(s):  
Chris S. Thomas ◽  
Doug R. Braun ◽  
Jose Luis Olmos ◽  
Scott R. Rajski ◽  
George N. Phillips ◽  
...  
Keyword(s):  
Metal Complex ◽  
Metal Complexes ◽  
Effective Treatment ◽  
Human Health ◽  
Treatment Options ◽  
New Delhi ◽  
New Class ◽  
Carbapenem Resistant ◽  
Carbapenem Resistant Enterobacteriaceae

Carbapenem-resistant Enterobacteriaceae continue to threaten human health worldwide with few effective treatment options. New Delhi metallo--lactamase (NDM) enzymes are a contributing element that drive resistance to many -lactam- and carbapenem-based antimicrobials. Many NDM inhibitors are known, yet none are clinically viable. In this study, we present and characterize a new class of NDM-1 inhibitors based on a pyridine-2,6-dithiocarboxylic acid metal complex scaffold. These complexes display varied and unique activity profiles against NDM-1 in kinetic assays and serve to increase the effectiveness of meropenem, an established antibacterial, in assays using clinical Enterobacteriaceae isolates.

ChemInform Abstract: Antitumor Agents. Part 269 Non-aromatic Ring-A Neotanshinlactone Analogue, TNO, as a New Class of Potent Antitumor Agents.

ChemInform ◽  
2010 ◽  
Vol 41 (12) ◽  
Author(s):  
Yizhou Dong ◽  
Qian Shi ◽  
Kyoko Nakagawa-Goto ◽  
Pei-Chi Wu ◽  
Kenneth F. Bastow ◽  
...  
Keyword(s):  
Aromatic Ring ◽  
Antitumor Agents ◽  
New Class
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