Enzyme inhibitors. XX. The hydrophobic and hydroxyl-binding regions of adenosine deaminase. 9-(2-m-Bromo-acetamidophenethyl)adenine, a new irreversible inhibitor of adenosine deaminase

Howard J. Schaeffer; Roland Norman Johnson

doi:10.1021/jm00307a004

Enzyme inhibitors. XX. The hydrophobic and hydroxyl-binding regions of adenosine deaminase. 9-(2-m-Bromo-acetamidophenethyl)adenine, a new irreversible inhibitor of adenosine deaminase

Journal of Medicinal Chemistry ◽

10.1021/jm00307a004 ◽

1968 ◽

Vol 11 (1) ◽

pp. 21-26 ◽

Cited By ~ 6

Author(s):

Howard J. Schaeffer ◽

Roland Norman Johnson

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor ◽

Binding Regions

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Enzyme Inhibitors. XV. A New Irreversible Inhibitor of Adenosine Deaminase

Journal of Medicinal Chemistry ◽

10.1021/jm00314a012 ◽

1967 ◽

Vol 10 (2) ◽

pp. 181-185 ◽

Cited By ~ 6

Author(s):

Howard J. Schaeffer ◽

Eugene. Odin

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Enzyme Inhibitors XII. Synthesis of an Active-Site-Directed Irreversible Inhibitor of Adenosine Deaminase

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600540834 ◽

1965 ◽

Vol 54 (8) ◽

pp. 1223-1224 ◽

Cited By ~ 7

Author(s):

Howard J. Schaeffer ◽

Eugene Odin

Keyword(s):

Adenosine Deaminase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors 100 Inhibitors of thymidine phosphorylase 8. 6-(p-bromoacetamido-benzyl)uracil, an active-site-directed irreversible inhibitor

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600560907 ◽

1967 ◽

Vol 56 (9) ◽

pp. 1086-1092 ◽

Cited By ~ 4

Author(s):

B.R. Baker ◽

Mitsutaka Kawazu

Keyword(s):

Active Site ◽

Thymidine Phosphorylase ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors. CXXXIX. p-(4,6-Diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. 6. Effects of substitution on the propionamide bridge on isozyme specificity

Journal of Medicinal Chemistry ◽

10.1021/jm00301a024 ◽

1969 ◽

Vol 12 (1) ◽

pp. 92-94

Author(s):

Bernard Randall Baker ◽

Gerhardus J. Lourens

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines

Journal of Medicinal Chemistry ◽

10.1021/jm00247a002 ◽

1974 ◽

Vol 17 (1) ◽

pp. 6-8 ◽

Cited By ~ 220

Author(s):

Howard J. Schaeffer ◽

Charles F. Schwender

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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Irreversible enzyme inhibitors. CXXIX. p-(4,6-Diamino-1,2-dihydro-2,2-dimethyl-s-triazine-l-yl)phenylpropionylsulfanilyl fluoride, an active site-directed irreversible inhibitor of dihydrofolic reductase. 5. Effects of substitution on the benzenesulfonyl fluoride moiety on isozyme specificity

Journal of Medicinal Chemistry ◽

10.1021/jm00310a009 ◽

1968 ◽

Vol 11 (4) ◽

pp. 677-682 ◽

Cited By ~ 5

Author(s):

B. R. Baker ◽

Gerhardus J. Lourens

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Enzyme Inhibitors XXIII: Syntheses of 9-(Substituted Aralkyl)-6-Substituted Purines as Inhibitors of Adenosine Deaminase

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600600814 ◽

1971 ◽

Vol 60 (8) ◽

pp. 1184-1188 ◽

Cited By ~ 3

Author(s):

Howard J. Schaeffer ◽

Eugene Odin ◽

Shmuel Bittner

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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Irreversible Enzyme Inhibitors. XCV. 8-(m-Bromoacetamidobenzylthio)hypoxanthine, an Active-Site-Directed Irreversible Inhibitor of Xanthine Oxidase1-3

Journal of Medicinal Chemistry ◽

10.1021/jm00316a035 ◽

1967 ◽

Vol 10 (4) ◽

pp. 682-685 ◽

Cited By ~ 5

Author(s):

B. R. Baker ◽

Janos. Kozma

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Enzyme Inhibitors. VI. Studies on the Bulk Tolerance of Adenosine Deaminase for 6-Substituted Amino-9-(3-hydroxypropyl)purines1

Journal of Medicinal Chemistry ◽

10.1021/jm00325a008 ◽

1965 ◽

Vol 8 (1) ◽

pp. 33-35 ◽

Cited By ~ 17

Author(s):

Howard J. Schaeffer ◽

Robert Vince

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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Irreversible Enzyme Inhibitors. CVIII.1,26-(p-Chloroacetylanilinomethyl)-5-(p-chlorophenyl)-2, 4-diaminopyrimidine, an Active-Site-Directed Irreversible Inhibitor of Dihydrofolic Reductase

Journal of Medicinal Chemistry ◽

10.1021/jm00318a032 ◽

1967 ◽

Vol 10 (6) ◽

pp. 1134-1138 ◽

Cited By ~ 1

Author(s):

B. R. Baker ◽

Ping Cheong. Huang ◽

Alfonso L. Pogolotti

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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