Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines

Howard J. Schaeffer; Charles F. Schwender

doi:10.1021/jm00247a002

Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines

Journal of Medicinal Chemistry ◽

10.1021/jm00247a002 ◽

1974 ◽

Vol 17 (1) ◽

pp. 6-8 ◽

Cited By ~ 220

Author(s):

Howard J. Schaeffer ◽

Charles F. Schwender

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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Enzyme inhibitors. XX. The hydrophobic and hydroxyl-binding regions of adenosine deaminase. 9-(2-m-Bromo-acetamidophenethyl)adenine, a new irreversible inhibitor of adenosine deaminase

Journal of Medicinal Chemistry ◽

10.1021/jm00307a004 ◽

1968 ◽

Vol 11 (1) ◽

pp. 21-26 ◽

Cited By ~ 6

Author(s):

Howard J. Schaeffer ◽

Roland Norman Johnson

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor ◽

Binding Regions

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Enzyme Inhibitors XXIII: Syntheses of 9-(Substituted Aralkyl)-6-Substituted Purines as Inhibitors of Adenosine Deaminase

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600600814 ◽

1971 ◽

Vol 60 (8) ◽

pp. 1184-1188 ◽

Cited By ~ 3

Author(s):

Howard J. Schaeffer ◽

Eugene Odin ◽

Shmuel Bittner

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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Enzyme Inhibitors. VI. Studies on the Bulk Tolerance of Adenosine Deaminase for 6-Substituted Amino-9-(3-hydroxypropyl)purines1

Journal of Medicinal Chemistry ◽

10.1021/jm00325a008 ◽

1965 ◽

Vol 8 (1) ◽

pp. 33-35 ◽

Cited By ~ 17

Author(s):

Howard J. Schaeffer ◽

Robert Vince

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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Enzyme Inhibitors. XV. A New Irreversible Inhibitor of Adenosine Deaminase

Journal of Medicinal Chemistry ◽

10.1021/jm00314a012 ◽

1967 ◽

Vol 10 (2) ◽

pp. 181-185 ◽

Cited By ~ 6

Author(s):

Howard J. Schaeffer ◽

Eugene. Odin

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Enzyme Inhibitors. XVII. Kinetic Studies on the Irreversible Inhibition of Adenosine Deaminase

Journal of Medicinal Chemistry ◽

10.1021/jm00316a036 ◽

1967 ◽

Vol 10 (4) ◽

pp. 686-689 ◽

Cited By ~ 9

Author(s):

Howard J. Schaeffer ◽

Michael A. Schwartz ◽

Eugene. Odin

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors ◽

Kinetic Studies ◽

Irreversible Inhibition

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Enzyme Inhibitors XXIV: Bridging Hydrophobic and Hydrophilic Regions on Adenosine Deaminase

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600600818 ◽

1971 ◽

Vol 60 (8) ◽

pp. 1204-1209 ◽

Cited By ~ 10

Author(s):

Howard J. Schaeffer ◽

Charles F. Schwender

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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Enzyme Inhibitors. XVIII. Studies on the Stereoselectivity of Inhibition of Adenosine Deaminase by DL-, D-, and L-9-(2-Hydroxypropyl)adenine

Journal of Medicinal Chemistry ◽

10.1021/jm00316a037 ◽

1967 ◽

Vol 10 (4) ◽

pp. 689-691 ◽

Cited By ~ 19

Author(s):

Howard J. Schaeffer ◽

Robert. Vince

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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Enzyme Inhibitors XII. Synthesis of an Active-Site-Directed Irreversible Inhibitor of Adenosine Deaminase

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600540834 ◽

1965 ◽

Vol 54 (8) ◽

pp. 1223-1224 ◽

Cited By ~ 7

Author(s):

Howard J. Schaeffer ◽

Eugene Odin

Keyword(s):

Adenosine Deaminase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Time-resolved fluorescence spectroscopy of human adenosine deaminase: effects of enzyme inhibitors on protein conformation

Biochemistry ◽

10.1021/bi00431a012 ◽

1989 ◽

Vol 28 (5) ◽

pp. 2040-2050 ◽

Cited By ~ 9

Author(s):

Anne V. Philips ◽

Mary Sue Coleman ◽

Karol Maskos ◽

Mary D. Barkley

Keyword(s):

Fluorescence Spectroscopy ◽

Adenosine Deaminase ◽

Protein Conformation ◽

Enzyme Inhibitors ◽

Time Resolved Fluorescence ◽

Time Resolved

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Enzyme inhibitors. 25. Equation to calculate the unknown Ki from two known values of Ki in an R,S, and RS series. Stereoselectivity of inhibition of adenosine deaminase by (R)-, (S)-, and (RS)-9-(1-hydroxy-2-alkyl and -aralkyl)adenines

Journal of Medicinal Chemistry ◽

10.1021/jm00275a003 ◽

1972 ◽

Vol 15 (5) ◽

pp. 456-458 ◽

Cited By ~ 11

Author(s):

Howard J. Schaeffer ◽

R. N. Johnson ◽

Michael A. Schwartz ◽

Charles F. Schwender

Keyword(s):

Adenosine Deaminase ◽

Enzyme Inhibitors

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