Irreversible enzyme inhibitors. CLXXVI. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine by ether bridging to a terminal sulfonyl fluoride

Bernard Randall Baker; Wallace T. Ashton

doi:10.1021/jm00300a029

Irreversible enzyme inhibitors. CLXXVI. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine by ether bridging to a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00300a029 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1149-1154 ◽

Cited By ~ 2

Author(s):

Bernard Randall Baker ◽

Wallace T. Ashton

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CLXXVIII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00300a031 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1161-1165 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Wallace T. Ashton

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal phenylene sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00302a007 ◽

1969 ◽

Vol 12 (2) ◽

pp. 224-227 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Rich B. Meyer

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Ireversible enzyme inhibitors. CLXXIX. Active-site-directed irreversible enzyme inhibitors of dihydrofolate reductase from 1-(3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with oxyamide bridges to a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00300a032 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1165-1170 ◽

Cited By ~ 3

Author(s):

Bernard Randall Baker ◽

Wallace T. Ashton

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CXII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine substituted with a terminal sulfonyl fluoride. 2

Journal of Medicinal Chemistry ◽

10.1021/jm00307a007 ◽

1968 ◽

Vol 11 (1) ◽

pp. 38-41 ◽

Cited By ~ 5

Author(s):

Bernard Randall Baker ◽

Gerhardus J. Lourens

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group

Journal of Medicinal Chemistry ◽

10.1021/jm00279a017 ◽

1972 ◽

Vol 15 (9) ◽

pp. 945-947 ◽

Cited By ~ 3

Author(s):

B. R. Baker ◽

Wallace T. Ashton

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Sulfonate Group ◽

Irreversible Inhibitors

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Irreversible enzyme inhibitors. CLXXVII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(phenylalkylphenyl)-s-triazines. II

Journal of Medicinal Chemistry ◽

10.1021/jm00300a030 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1154-1160 ◽

Cited By ~ 12

Author(s):

Bernard Randall Baker ◽

Nicolaas M. J. Vermeulen

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors

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Irreversible enzyme inhibitors. CXLVII. Candidate active-site- directed irreversible inhibitors of xanthine oxidase derived from 9-(p-acylaminoalkoxyphenyl)guanines bearing a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00302a004 ◽

1969 ◽

Vol 12 (2) ◽

pp. 214-216 ◽

Cited By ~ 14

Author(s):

Bernard Randall Baker ◽

William F. Wood

Keyword(s):

Xanthine Oxidase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CLV. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[4-.omega.-aminoalkoxy)-3-chlorophenyl]-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazines bearing a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00304a025 ◽

1969 ◽

Vol 12 (4) ◽

pp. 672-676 ◽

Cited By ~ 2

Author(s):

Bernard Randall Baker ◽

Eunice E. Janson

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CXIX. Active-site-directed irreversible inhibitors of dihydrofolic reductase with tissue specificity derived from 2,4,6-triaminopyrimidine with a terminal sulfonyl fluoride at the 5 position

Journal of Medicinal Chemistry ◽

10.1021/jm00309a018 ◽

1968 ◽

Vol 11 (3) ◽

pp. 489-494 ◽

Cited By ~ 6

Author(s):

Bernard Randall Baker ◽

Rich B. Meyer

Keyword(s):

Active Site ◽

Tissue Specificity ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CLXXII. Proteolytic enzymes. XVI. Covalent bonding of the sulfonyl fluoride group to serine outside the active-site of .alpha.-chymotrypsin by exo-type active-site directed irreversible inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00297a030 ◽

1970 ◽

Vol 13 (3) ◽

pp. 467-470 ◽

Cited By ~ 10

Author(s):

Robert Cardinaud ◽

Bernard Randall Baker

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Proteolytic Enzymes ◽

Covalent Bonding ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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