Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group

B. R. Baker; Wallace T. Ashton

doi:10.1021/jm00279a017

Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group

Journal of Medicinal Chemistry ◽

10.1021/jm00279a017 ◽

1972 ◽

Vol 15 (9) ◽

pp. 945-947 ◽

Cited By ~ 3

Author(s):

B. R. Baker ◽

Wallace T. Ashton

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Sulfonate Group ◽

Irreversible Inhibitors

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Irreversible enzyme inhibitors. CLXXVII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(phenylalkylphenyl)-s-triazines. II

Journal of Medicinal Chemistry ◽

10.1021/jm00300a030 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1154-1160 ◽

Cited By ~ 12

Author(s):

Bernard Randall Baker ◽

Nicolaas M. J. Vermeulen

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors

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Irreversible enzyme inhibitors. CLXXVI. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine by ether bridging to a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00300a029 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1149-1154 ◽

Cited By ~ 2

Author(s):

Bernard Randall Baker ◽

Wallace T. Ashton

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CLXXVIII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00300a031 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1161-1165 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Wallace T. Ashton

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CXI. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-l-phenyl-s-triazines. V.

Journal of Heterocyclic Chemistry ◽

10.1002/jhet.5570040408 ◽

1967 ◽

Vol 4 (4) ◽

pp. 507-510 ◽

Cited By ~ 1

Author(s):

B. R. Baker ◽

Morris A. Johnson

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors

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Irreversible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal phenylene sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00302a007 ◽

1969 ◽

Vol 12 (2) ◽

pp. 224-227 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Rich B. Meyer

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Ireversible enzyme inhibitors. CLXXIX. Active-site-directed irreversible enzyme inhibitors of dihydrofolate reductase from 1-(3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with oxyamide bridges to a terminal sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00300a032 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1165-1170 ◽

Cited By ~ 3

Author(s):

Bernard Randall Baker ◽

Wallace T. Ashton

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Enzyme Inhibitors ◽

Sulfonyl Fluoride

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ACTIVE-SITE DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1971.tb31146.x ◽

1971 ◽

Vol 186 (1 Folate Antago) ◽

pp. 214-226 ◽

Cited By ~ 31

Author(s):

B. R. Baker

Keyword(s):

Dihydrofolate Reductase ◽

Active Site ◽

Irreversible Inhibitors

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ChemInform Abstract: IRREVERSIBLE ENZYME INHIBITORS. 202. CANDIDATE ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF 5-FLUORO-2′-DEOXYURIDINE PHOSPHORYLASE FROM WALKER 256 RAT TUMOR DERIVED FROM 1-BENZYL-5-(3-ETHOXYBENZYL)URACIL

Chemischer Informationsdienst ◽

10.1002/chin.198241232 ◽

1982 ◽

Vol 13 (41) ◽

Author(s):

J. L. KELLEY ◽

B. R. BAKER

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Walker 256 ◽

Rat Tumor

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Irreversible enzyme inhibitors. CXII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine substituted with a terminal sulfonyl fluoride. 2

Journal of Medicinal Chemistry ◽

10.1021/jm00307a007 ◽

1968 ◽

Vol 11 (1) ◽

pp. 38-41 ◽

Cited By ~ 5

Author(s):

Bernard Randall Baker ◽

Gerhardus J. Lourens

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Irreversible enzyme inhibitors. CLXVI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with 6 substituents and some factors in their cell wall transport

Journal of Medicinal Chemistry ◽

10.1021/jm00295a021 ◽

1970 ◽

Vol 13 (1) ◽

pp. 82-86 ◽

Cited By ~ 5

Author(s):

Bernard Randall Baker ◽

Nicolaas M. J. Vermeulen

Keyword(s):

Cell Wall ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors

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