Quantitative structure-activity relation of reversible dihydrofolate reductase inhibitors. Diaminotriazines

Corwin Hansch; Carlo Silipo

doi:10.1021/jm00253a001

Quantitative structure-activity relation of reversible dihydrofolate reductase inhibitors. Diaminotriazines

Journal of Medicinal Chemistry ◽

10.1021/jm00253a001 ◽

1974 ◽

Vol 17 (7) ◽

pp. 661-667 ◽

Cited By ~ 17

Author(s):

Corwin Hansch ◽

Carlo Silipo

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Dihydrofolate Reductase Inhibitors ◽

Quantitative Structure Activity Relation

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Applications of neural networks in quantitative structure-activity relationships of dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00113a022 ◽

1991 ◽

Vol 34 (9) ◽

pp. 2824-2836 ◽

Cited By ~ 201

Author(s):

T. A. Andrea ◽

Hooshmand Kalayeh

Keyword(s):

Neural Networks ◽

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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ChemInform Abstract: USE OF PHYSICOCHEMICAL PARAMETERS IN DISTANCE GEOMETRY AND RELATED THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS: A DEMONSTRATION USING ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE INHIBITORS

Chemischer Informationsdienst ◽

10.1002/chin.198532378 ◽

1985 ◽

Vol 16 (32) ◽

Author(s):

A. K. GHOSE ◽

G. M. CRIPPEN

Keyword(s):

Escherichia Coli ◽

Dihydrofolate Reductase ◽

Physicochemical Parameters ◽

Distance Geometry ◽

Three Dimensional ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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ChemInform Abstract: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS BY DISTANCE GEOMETRY: SYSTEMATIC ANALYSIS OF DIHYDROFOLATE REDUCTASE INHIBITORS

Chemischer Informationsdienst ◽

10.1002/chin.198042296 ◽

1980 ◽

Vol 11 (42) ◽

Author(s):

G. M. CRIPPEM

Keyword(s):

Dihydrofolate Reductase ◽

Distance Geometry ◽

Quantitative Structure ◽

Systematic Analysis ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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Dihydrofolate reductase inhibitors: a quantitative structure–activity relationship study using 2D-QSAR and 3D-QSAR methods

Medicinal Chemistry Research ◽

10.1007/s00044-016-1742-4 ◽

2016 ◽

Vol 26 (1) ◽

pp. 247-261 ◽

Cited By ~ 5

Author(s):

Juan C. Garro Martinez ◽

Matias F. Andrada ◽

Esteban G. Vega-Hissi ◽

Francisco M. Garibotto ◽

Manuel Nogueras ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

3D Qsar ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

2D Qsar ◽

Reductase Inhibitors ◽

Structure Activity ◽

Relationship Study ◽

Dihydrofolate Reductase Inhibitors

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Quantitative structure-activity relationships by distance geometry: systematic analysis of dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00180a004 ◽

1980 ◽

Vol 23 (6) ◽

pp. 599-606 ◽

Cited By ~ 35

Author(s):

Gordon M. Crippen

Keyword(s):

Dihydrofolate Reductase ◽

Distance Geometry ◽

Quantitative Structure ◽

Systematic Analysis ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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Use of physicochemical parameters in distance geometry and related three-dimensional quantitative structure-activity relationships: A demonstration using Escherichia coli dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00381a013 ◽

1985 ◽

Vol 28 (3) ◽

pp. 333-346 ◽

Cited By ~ 62

Author(s):

Arup K. Ghose ◽

Gordon M. Crippen

Keyword(s):

Escherichia Coli ◽

Dihydrofolate Reductase ◽

Physicochemical Parameters ◽

Distance Geometry ◽

Three Dimensional ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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Evolutionary Neural Networks in Quantitative Structure-Activity Relationships of Dihydrofolate Reductase Inhibitors

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.19960150404 ◽

1996 ◽

Vol 15 (4) ◽

pp. 296-301 ◽

Cited By ~ 11

Author(s):

Jari KyngÃ¤s ◽

Jarkko Valjakka

Keyword(s):

Neural Networks ◽

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Evolutionary Neural Networks ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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ChemInform Abstract: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP BY DISTANCE GEOMETRY: QUINAZOLINES AS DIHYDROFOLATE REDUCTASE INHIBITORS

Chemischer Informationsdienst ◽

10.1002/chin.198304225 ◽

1983 ◽

Vol 14 (4) ◽

Author(s):

A. K. GHOSE ◽

G. M. CRIPPEN

Keyword(s):

Dihydrofolate Reductase ◽

Distance Geometry ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Dihydrofolate Reductase Inhibitors

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Quantitative Structure Activity Relationships of Dihydrofolate Reductase Inhibitors by Neural Networks

Protein Engineering Design and Selection ◽

10.1093/protein/6.supplement.107-b ◽

1993 ◽

Keyword(s):

Neural Networks ◽

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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The method of frontal polyhedra for conformationally-nonrigid molecules. Quantitative structure—Activity relationship in the series of baker triazines—Dihydrofolate reductase inhibitors

Pharmaceutical Chemistry Journal ◽

10.1007/bf02464669 ◽

1997 ◽

Vol 31 (3) ◽

pp. 147-154 ◽

Cited By ~ 1

Author(s):

A. I. Khlebnikov

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Nonrigid Molecules ◽

Reductase Inhibitors ◽

Structure Activity ◽

Dihydrofolate Reductase Inhibitors

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