Analogs of phenothiazines. 6. Stereochemical assignment of isomeric aminoalkylidene derivatives of xanthenes and thioxanthenes with neuropharmacological activity

1974 ◽  
Vol 17 (1) ◽  
pp. 131-133 ◽  
Author(s):  
Carl Kaiser ◽  
Richard J. Warren ◽  
Charles L. Zirkle
Keyword(s):  
Stereochemical Assignment ◽  
Neuropharmacological Activity ◽  
Derivatives Of

Studies of Australian Soft Corals. XII. Further Cembranolide Diterpenes from Lobophytum crassospiculatum and a Correction of a Previous Stereochemical Assignment

1979 ◽  
Vol 32 (6) ◽  
pp. 1273 ◽  
Author(s):  
A Ahond ◽  
BF Bowden ◽  
JC Coll ◽  
J Fourneron ◽  
SJ Mitchell
Keyword(s):  
Spectroscopic Data ◽  
The Other ◽  
Chemical Degradation ◽  
Soft Corals ◽  
Stereochemical Assignment ◽  
Derivatives Of

Three new cembranolide diterpenes from Lobophytum crassospiculatum are reported. The structure of one of these was deduced from spectroscopic data and chemical degradation, then confirmed as (E,E,E)-6,10,14-trimethyl-3-methylene-trans-3a,4,7,8,11,12,15,15a- octahydrocyclotetradeca[b]furan-2(3H)-one (3), by synthesis from the previously reported (2). The other two diterpenes,(4) and (5), are shown to be the epimeric 15-acetoxyl derivatives of (2).

Analogs of phenothiazines. 5. Synthesis and neuropharmacological activity of some piperidylidene derivatives of thioxanthenes, xanthenes, dibenzoxepins, and acridans

1974 ◽  
Vol 17 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Carl Kaiser ◽  
Philip J. Fowler ◽  
David H. Tedeschi ◽  
Bruce M. Lester ◽  
Eleanor Garvey ◽  
...  
Keyword(s):  
Neuropharmacological Activity ◽  
Derivatives Of

Fragmentation of isomeric dideoxy derivatives of 1,6-anhydro-β-D-hexopyranoses under electron impact

1981 ◽  
Vol 46 (10) ◽  
pp. 2390-2403 ◽  
Author(s):  
František Tureček ◽  
Tomáš Trnka ◽  
Miloslav Černý
Keyword(s):  
Electron Impact ◽  
Mass Spectra ◽  
Hydroxyl Group ◽  
Fragmentation Pattern ◽  
Positional Isomers ◽  
Deuterium Labeling ◽  
Stereochemical Assignment ◽  
Electron Impact Mass ◽  
Derivatives Of ◽  
Impact Mass

Electron impact mass spectra of all possible dideoxy derivatives of 1,6-anhydro-β-D-hexopyranoses and their sixteen specifically deuterium-labeled derivatives are reported. The spectra of positional isomers differ considerably making possible the reliable location of the hydroxyl group by mass spectrometry. The configuration of the hydroxyl group at C(2) and C(4) has only a negligible effect on the fragmentation pattern of stereoisomers. However, mass spectra of the C(3)-configurational isomers differ sufficiently to permit a stereochemical assignment. The fragmentation paths were elucidated by means of deuterium labeling and metastable spectra.

Synthesis and neuropharmacological activity of disulfide derivatives of pyridoxine

1988 ◽  
Vol 22 (10) ◽  
pp. 747-749
Author(s):  
M. A. Kovler ◽  
A. L. Karaev ◽  
M. V. Balyakina ◽  
Z. N. Zhukova ◽  
V. M. Avakumov ◽  
...  
Keyword(s):  
Neuropharmacological Activity ◽  
Derivatives Of
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