ChemInform Abstract: Enzymatic and Chemoenzymatic Synthesis and Stereochemical Assignment of cis-Dihydrodiol Derivatives of Monosubstituted Benzenes.

ChemInform ◽  
2010 ◽  
Vol 29 (46) ◽  
pp. no-no
Author(s):  
D. R. BOYD ◽  
N. D. SHARMA ◽  
B. BYRNE ◽  
M. V. HAND ◽  
J. F. MALONE ◽  
...  
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Stereochemical Assignment ◽  
Monosubstituted Benzenes ◽  
Derivatives Of

Chemoenzymatic synthesis of trans-dihydrodiol derivatives of monosubstituted benzenes from the corresponding cis-dihydrodiol isomers

2007 ◽  
Vol 5 (3) ◽  
pp. 514 ◽  
Author(s):  
Derek R. Boyd ◽  
Narain D. Sharma ◽  
Nuria M. Llamas ◽  
Gerard P. Coen ◽  
Peter K. M. McGeehin ◽  
...  
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Monosubstituted Benzenes ◽  
Derivatives Of

Chemoenzymatic synthesis of the trans-dihydrodiol isomers of monosubstituted benzenes viaanti-benzene dioxides

2006 ◽  
Vol 4 (11) ◽  
pp. 2208 ◽  
Author(s):  
Derek R. Boyd ◽  
Narain D. Sharma ◽  
Nuria M. Llamas ◽  
Colin R. O'Dowd ◽  
Christopher C. R. Allen
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Monosubstituted Benzenes

scholarly journals Chemoenzymatic Synthesis and Some Biological Properties of O-phosphoryl Derivatives of (E)-resveratrol

2008 ◽  
Vol 3 (10) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Danilo Aleo ◽  
Venera Cardile ◽  
Rosa Chillemi ◽  
Giuseppe Granata ◽  
Sebastiano Sciuto
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Binding Affinity ◽  
Spectroscopic Investigation ◽  
Biological Properties ◽  
Chemoenzymatic Synthesis ◽  
Prostate Cancer Cells ◽  
Phosphoramidite Chemistry ◽  
Protective Groups ◽  
Derivatives Of

3- O-, 3,5-di- O- and 4′- O-phosphoryl derivatives of ( E)-resveratrol have been obtained following a chemoenzymatic strategy. Variedly acylated resveratrol derivatives have been obtained first by exploiting regioselective properties of Pseudomonas cepacea or Candida antarctica lipases in organic solvents. Each acyl-resveratrol was then phosphorylated by the phosphoramidite chemistry protocol and in sequence freed of protective groups, affording the desired O-phosphoryl derivative. Following UV-absorption spectroscopic investigation on the interaction of the newly synthesized compounds with DNA, 4′- O-phosphorylresveratrol exhibited the best binding affinity. As a result of cytotoxicity tests, 3- O-phosphorylresveratrol was more active than resveratrol against DU 145 prostate cancer cells.

ChemInform Abstract: Chemoenzymatic Synthesis of the 2,3- and 3,4-cis-Dihydrodiol Enantiomers of Monosubstituted Benzenes.

ChemInform ◽  
2010 ◽  
Vol 25 (24) ◽  
pp. no-no
Author(s):  
D. R. BOYD ◽  
N. D. SHARMA ◽  
S. A. BARR ◽  
H. DALTON ◽  
J. CHIMA ◽  
...  
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Monosubstituted Benzenes

Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study

2018 ◽  
Vol 78 ◽  
pp. 210-219 ◽  
Author(s):  
M. Antonela Zígolo ◽  
Maximiliano Salinas ◽  
Laura Alché ◽  
Alicia Baldessari ◽  
Guadalupe García Liñares
Keyword(s):  
Molecular Docking ◽  
Antiviral Activity ◽  
Docking Study ◽  
Glycyrrhetinic Acid ◽  
Chemoenzymatic Synthesis ◽  
Molecular Docking Study ◽  
Derivatives Of

Studies of Australian Soft Corals. XII. Further Cembranolide Diterpenes from Lobophytum crassospiculatum and a Correction of a Previous Stereochemical Assignment

1979 ◽  
Vol 32 (6) ◽  
pp. 1273 ◽  
Author(s):  
A Ahond ◽  
BF Bowden ◽  
JC Coll ◽  
J Fourneron ◽  
SJ Mitchell
Keyword(s):  
Spectroscopic Data ◽  
The Other ◽  
Chemical Degradation ◽  
Soft Corals ◽  
Stereochemical Assignment ◽  
Derivatives Of

Three new cembranolide diterpenes from Lobophytum crassospiculatum are reported. The structure of one of these was deduced from spectroscopic data and chemical degradation, then confirmed as (E,E,E)-6,10,14-trimethyl-3-methylene-trans-3a,4,7,8,11,12,15,15a- octahydrocyclotetradeca[b]furan-2(3H)-one (3), by synthesis from the previously reported (2). The other two diterpenes,(4) and (5), are shown to be the epimeric 15-acetoxyl derivatives of (2).

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