Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 2

1976 ◽  
Vol 19 (11) ◽  
pp. 1302-1308 ◽  
Author(s):  
Feng-Te Chou ◽  
A. Hameed Khan ◽  
John S. Driscoll
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Antitumor Agents

scholarly journals Neoplastic Meningitis from Solid Tumors: A Prospective Clinical Study in Lombardia and a Literature Review on Therapeutic Approaches

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
A. Silvani ◽  
M. Caroli ◽  
P. Gaviani ◽  
V. Fetoni ◽  
R. Merli ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Solid Tumors ◽  
Antitumor Agents ◽  
Palliative Radiotherapy ◽  
Symptomatic Treatment ◽  
Diagnostic Techniques ◽  
Prospective Clinical Study ◽  
Pattern Of Care ◽  
Bulky Disease

Neoplastic dissemination to the leptomeninges is an increasingly common occurrence in patients with both haematological and solid tumors arising outside the central nervous system. Both refinement of diagnostic techniques (Magnetic resonance imaging) and increased survival in patients treated with targeted therapies for systemic tumors account for this increased frequency. Cerebrospinal fluid cytological analysis and MRI confirm clinical diagnosis based on multifocal central nervous system signs/symptoms in a patient with known malignancy. Overall survival in patients with leptomeningeal neoplastic dissemination from solid tumors is short, rarely exceeding 3-4 months. However, selected patients may benefit from aggressive therapies, Apart from symptomatic treatment, intrathecal chemotherapy is used, with both free (methotrexate, Thiotepa, AraC) and liposomal antitumor agents (liposomal AraC). Palliative radiotherapy is indicated only in cases of symptomatic bulky disease, surgery is limited to positioning of Ommaya recervoirs or C5F shunting. We report clinical data on a cohort of 26 prospectively followed patients with neoplastic leptomeningitis followed in Lombardia, Italy, in 2011. Prognostic factors and pattern of care are reported.

Antioxidant, α-glucosidase inhibitory and in vitro antitumor activities of coumarin-benzothiazole hybrids

2018 ◽  
Vol 24 (5) ◽  
pp. 243-247 ◽  
Author(s):  
Moustafa T. Gabr
Keyword(s):  
Ovarian Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Lines ◽  
Antitumor Agents ◽  
Maximal Growth ◽  
Antitumor Activities ◽  
Cns Cancer ◽  
Inhibitory Activities

Abstract Coumarin-benzothiazole hybrids are antitumor agents based on their antioxidant and α-glucosidase inhibitory activities. Compounds 5a–c were selected by National Cancer Institute (NCI), USA, to be screened for antitumor activity at a single dose (10 μm) against a panel of 60 cancer cell lines. The most active compound 5c was further screened at a five-dose level by NCI. Compound 5c displays half maximal growth inhibition (GI50) values of 0.24 and 0.33 μm against central nervous system (CNS) cancer (SNB-75) and ovarian cancer (OVCAR-4) cell lines, respectively. Compounds 5a–c were also screened for their antioxidant and α-glucosidase inhibitory activities.

ChemInform Abstract: POTENTIAL CENTRAL NERVOUS SYSTEM ANTITUMOR AGENTS. AZIRIDINYLBENZOQUINONES. 2

1977 ◽  
Vol 8 (9) ◽  
pp. no-no
Author(s):  
FENG-TE CHOU FENG-TE CHOU ◽  
A. H. KHAN ◽  
J. S. DRISCOLL
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Antitumor Agents

Isoquinolines. 6. Potential central nervous system antitumor agents. Nitrogen mustards of 3-amino-4-(p-aminophenyl)isoquinoline

1977 ◽  
Vol 20 (11) ◽  
pp. 1504-1508 ◽  
Author(s):  
Crist N. Filer ◽  
Felix E. Granchelli ◽  
Albert H. Soloway ◽  
John L. Neumeyer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Antitumor Agents ◽  
Nitrogen Mustards

scholarly journals New pharmaceuticals: The importance of serendipity

2020 ◽  
Vol 54 (4) ◽  
pp. 143-148
Author(s):  
Larisa Đurić ◽  
Maja Milanović ◽  
Nataša Milošević ◽  
Nataša Milić
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Antimicrobial Agents ◽  
Antitumor Agents ◽  
Drug Repositioning ◽  
Development Stage ◽  
Discovery Process ◽  
Biomedical Sciences ◽  
Knowledge And Skills ◽  
Active Substances

The key elements of serendipity are luck and contemplation. The discovery process includes the recognition of the finding potential based on knowledge and experience. Serendipitous discoveries are common in biomedical sciences. A significant number of pharmaceuticals is the result of serendipity. Drugs belonging to antimicrobial agents, central nervous system active substances as well as antitumor agents, gained great benefit from serendipity conditions. Besides in the traditional, irrational approach in the drug design, serendipitous discoveries have also played role in modern strategies, such as the drug repositioning and the development of multi-target antitumor agents. Serendipitous drugs discoveries can be classified as laboratory or clinical ones, depending on the drug development stage and the circumstances under which the combination of unforeseen events, the knowledge and skills of the researcher occurred. The discovery of a new drug is impossible without outstanding science as well as the dedication, freedom, and open-mindedness of the researcher to act, think, take a risk, and challenge dogmas.

Potential central nervous system antitumor agents. Hydantoin derivatives

1975 ◽  
Vol 18 (8) ◽  
pp. 846-849 ◽  
Author(s):  
Geoffrey W. Peng ◽  
Victor E. Marquez ◽  
John S. Driscoll
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Antitumor Agents ◽  
Hydantoin Derivatives
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