Synthesis and some pharmacological properties of the 23-peptide 15-lysine-secretin-(5-27). Special role of the residue in position 15 in biological activity of the vasoactive intestinal polypeptide

1978 ◽  
Vol 21 (11) ◽  
pp. 1171-1173 ◽  
Author(s):  
Miklos Bodanszky ◽  
Sesha Natarajan ◽  
Jerry D. Gardner ◽  
Gabriel M. Makhlouf ◽  
Sami I. Said
Keyword(s):  
Biological Activity ◽  
Vasoactive Intestinal Polypeptide ◽  
Special Role ◽  
Pharmacological Properties ◽  
Intestinal Polypeptide

scholarly journals Development-Dependent Plasticity in Vasoactive Intestinal Polypeptide Neurons in the Infralimbic Cortex

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Stuart A Collins ◽  
Ipe Ninan
Keyword(s):  
Sex Differences ◽  
Anxiety Disorders ◽  
Vasoactive Intestinal Polypeptide ◽  
Cortical Plasticity ◽  
Male Mice ◽  
Infralimbic Cortex ◽  
Membrane Excitability ◽  
Gabaergic Transmission ◽  
Intestinal Polypeptide

Abstract The onset of several neuropsychiatric disorders including anxiety disorders coincides with adolescence. Consistently, threat extinction, which plays a key role in the regulation of anxiety-related behaviors, is diminished during adolescence. Furthermore, this attenuated threat extinction during adolescence is associated with an altered synaptic plasticity in the infralimbic medial prefrontal cortex (IL-mPFC), a brain region critical for threat extinction. However, the mechanism underlying the altered plasticity in the IL-mPFC during adolescence is unclear. Given the purported role of vasoactive intestinal polypeptide expressing interneurons (VIPINs) in disinhibition and hence their potential to affect cortical plasticity, we examined whether VIPINs exhibit an adolescence-specific plasticity in the IL-mPFC. We observed an increase in GABAergic transmission and a decrease in excitability in VIPINs during adolescence. Male mice show a significantly higher VIPIN-pyramidal neuron GABAergic transmission compared with female mice. The observed increase in GABAergic transmission and a decrease in membrane excitability in VIPINs during adolescence could play a role in the altered plasticity in the adolescent IL-mPFC. Furthermore, the suppression of VIPIN-mediated GABAergic transmission in females might be relevant to sex differences in anxiety disorders.

The Role of Vasoactive Intestinal Polypeptide as a Neurotransmitter in Canine Penile Erection: A Combined in Vivo and Immunohistochemical Study

1987 ◽  
Vol 138 (4 Part 1) ◽  
pp. 871-877 ◽  
Author(s):  
Klaus-Peter Juenemann ◽  
Tom F. Lue ◽  
Jian-An Luo ◽  
Sami A. Jadallah ◽  
Lora L. Nunes ◽  
...  
Keyword(s):  
Vasoactive Intestinal Polypeptide ◽  
Penile Erection ◽  
Immunohistochemical Study ◽  
Intestinal Polypeptide

Possible Role of Vasoactive Intestinal Polypeptide on Prolactin Release during Suckling in Lactating Women

1987 ◽  
Vol 27 (4) ◽  
pp. 211-215 ◽  
Author(s):  
Ermanno Rolandi ◽  
Nicola Ragni ◽  
Roberto Fanceschini ◽  
Pier Luigi Venturing ◽  
Valeria Messina ◽  
...  
Keyword(s):  
Vasoactive Intestinal Polypeptide ◽  
Prolactin Release ◽  
Lactating Women ◽  
Intestinal Polypeptide

Role of vasoactive intestinal polypeptide in burn-induced oedema formation

Burns ◽  
2000 ◽  
Vol 26 (5) ◽  
pp. 443-448 ◽  
Author(s):  
L Lindblom ◽  
J Cassuto ◽  
L Yregård ◽  
P Tarnow ◽  
J Räntfors ◽  
...  
Keyword(s):  
Vasoactive Intestinal Polypeptide ◽  
Oedema Formation ◽  
Intestinal Polypeptide
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