Anticandidal activity of 5-fluorocytosine-peptide conjugates

1979 ◽  
Vol 22 (9) ◽  
pp. 1104-1109 ◽  
Author(s):  
Alvin S. Steinfeld ◽  
Fred Naider ◽  
Jeffrey M. Becker
Keyword(s):  
Peptide Conjugates ◽  
Anticandidal Activity

Transport of antimicrobial agents using peptide carrier systems: anticandidal activity of m-fluorophenylalanine-peptide conjugates

1983 ◽  
Vol 26 (12) ◽  
pp. 1725-1729 ◽  
Author(s):  
William D. Kingsbury ◽  
Jeffrey C. Boehm ◽  
Rajanikant J. Mehta ◽  
Sarah F. Grappel
Keyword(s):  
Antimicrobial Agents ◽  
Peptide Conjugates ◽  
Peptide Carrier ◽  
Anticandidal Activity ◽  
Carrier Systems

Anticandidal activity of pyrimidine-peptide conjugates

1980 ◽  
Vol 23 (8) ◽  
pp. 913-918 ◽  
Author(s):  
Jen-Shing Ti ◽  
Alvin S. Steinfeld ◽  
Fred Naider ◽  
Ali Gulumoglu ◽  
Sam V. Lewis ◽  
...  
Keyword(s):  
Peptide Conjugates ◽  
Anticandidal Activity

ChemInform Abstract: ANTICANDIDAL ACTIVITY OF PYRIMIDINE-PEPTIDE CONJUGATES

1981 ◽  
Vol 12 (5) ◽  
Author(s):  
J.-S. TI ◽  
A. S. STEINFELD ◽  
F. NAIDER ◽  
A. GULUMOGLU ◽  
S. V. LEWIS ◽  
...  
Keyword(s):  
Peptide Conjugates ◽  
Anticandidal Activity

Antibacterial and anticandidal activity studies on Sonchus erzincanicus Matthews

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
D Yiğit ◽  
N Yiğit ◽  
U Özgen ◽  
HG Sevindik ◽  
AE Aktaş
Keyword(s):  
Anticandidal Activity

68Ga-labeled HBED-CC Variant of uPAR Targeting Peptide AE105 Compared with 68Ga-NODAGA-AE105

2019 ◽  
Vol 18 (9) ◽  
pp. 1289-1294 ◽  
Author(s):  
Kusum Vats ◽  
Rohit Sharma ◽  
Haladhar D. Sarma ◽  
Drishty Satpati ◽  
Ashutosh Dash
Keyword(s):  
Solid Phase ◽  
Evaluation Studies ◽  
Radiochemical Yield ◽  
In Vivo Evaluation ◽  
Peptide Conjugates ◽  
Biodistribution Studies ◽  
Target Organs ◽  
U87mg Tumor

Aims: The urokinase Plasminogen Activator Receptors (uPAR) over-expressed on tumor cells and their invasive microenvironment are clinically significant molecular targets for cancer research. uPARexpressing cancerous lesions can be suitably identified and their progression can be monitored with radiolabeled uPAR targeted imaging probes. Hence this study aimed at preparing and evaluating two 68Ga-labeled AE105 peptide conjugates, 68Ga-NODAGA-AE105 and 68Ga-HBED-CC-AE105 as uPAR PET-probes. Method: The peptide conjugates, HBED-CC-AE105-NH2 and NODAGA-AE105-NH2 were manually synthesized by standard Fmoc solid phase strategy and subsequently radiolabeled with 68Ga eluted from a commercial 68Ge/68Ga generator. In vitro cell studies for the two radiotracers were performed with uPAR positive U87MG cells. Biodistribution studies were carried out in mouse xenografts with the subcutaneously induced U87MG tumor. Results: The two radiotracers, 68Ga-NODAGA-AE105 and 68Ga-HBED-CC-AE105 that were prepared in >95% radiochemical yield and >96% radiochemical purity, exhibited excellent in vitro stability. In vivo evaluation studies revealed higher uptake of 68Ga-HBED-CC-AE105 in U87MG tumor as compared to 68Ga-NODAGAAE105; however, increased lipophilicity of 68Ga-HBED-CC-AE105 resulted in slower clearance from blood and other non-target organs. The uPAR specificity of the two radiotracers was ascertained by significant (p<0.05) reduction in the tumor uptake with a co-injected blocking dose of unlabeled AE-105 peptide. Conclusion: Amongst the two radiotracers studied, the neutral 68Ga-NODAGA-AE105 with more hydrophilic chelator exhibited faster clearance from non-target organs. The conjugation of HBED-CC chelator (less hydrophilic) resulted in negatively charged 68Ga-HBED-CC-AE105 which was observed to have high retention in blood that decreased target to non-target ratios.

Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, and evaluation of antimicrobial activity and mammalian cytotoxicity

Peptides ◽  
2019 ◽  
Vol 117 ◽  
pp. 170079 ◽  
Author(s):  
Natalia Ptaszyńska ◽  
Katarzyna Olkiewicz ◽  
Joanna Okońska ◽  
Katarzyna Gucwa ◽  
Anna Łęgowska ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Synthesis ◽  
Peptide Conjugates
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