Antibacterial and anticandidal activity studies on Sonchus erzincanicus Matthews

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
D Yiğit ◽  
N Yiğit ◽  
U Özgen ◽  
HG Sevindik ◽  
AE Aktaş
Keyword(s):  
Anticandidal Activity

scholarly journals Design, Synthesis and Anticandidal Evaluation of Indazole and Pyrazole Derivatives

2021 ◽  
Vol 14 (3) ◽  
pp. 176
Author(s):  
Karen Rodríguez-Villar ◽  
Alicia Hernández-Campos ◽  
Lilián Yépez-Mulia ◽  
Teresita del Rosario Sainz-Espuñes ◽  
Olivia Soria-Arteche ◽  
...  
Keyword(s):  
Bloodstream Infections ◽  
Antifungal Drugs ◽  
Pyrazole Derivatives ◽  
Design Synthesis ◽  
Bioisosteric Replacement ◽  
Current Therapies ◽  
Anticandidal Activity ◽  
Resistant Strains ◽  
A Priority

Candidiasis, caused by yeasts of the genus Candida, is the second cause of superficial and mucosal infections and the fourth cause of bloodstream infections. Although some antifungal drugs to treat candidiasis are available, resistant strains to current therapies are emerging. Therefore, the search for new candicidal compounds is certainly a priority. In this regard, a series of indazole and pyrazole derivatives were designed in this work, employing bioisosteric replacement, homologation, and molecular simplification as new anticandidal agents. Compounds were synthesized and evaluated against C. albicans, C. glabrata, and C. tropicalis strains. The series of 3-phenyl-1H-indazole moiety (10a–i) demonstrated to have the best broad anticandidal activity. Particularly, compound 10g, with N,N-diethylcarboxamide substituent, was the most active against C. albicans and both miconazole susceptible and resistant C. glabrata species. Therefore, the 3-phenyl-1H-indazole scaffold represents an opportunity for the development of new anticandidal agents with a new chemotype.

scholarly journals Symbiotic NCR Peptide Fragments Affect the Viability, Morphology and Biofilm Formation of Candida Species

2021 ◽  
Vol 22 (7) ◽  
pp. 3666
Author(s):  
Bettina Szerencsés ◽  
Attila Gácser ◽  
Gabriella Endre ◽  
Ildikó Domonkos ◽  
Hilda Tiricz ◽  
...  
Keyword(s):  
Candida Species ◽  
Biofilm Formation ◽  
Therapeutic Potential ◽  
Fungal Infections ◽  
Combined Treatment ◽  
Antimicrobial Activities ◽  
Dilution Method ◽  
Model Legume ◽  
Anticandidal Activity

The increasing rate of fungal infections causes global problems not only in human healthcare but agriculture as well. To combat fungal pathogens limited numbers of antifungal agents are available therefore alternative drugs are needed. Antimicrobial peptides are potent candidates because of their broad activity spectrum and their diverse mode of actions. The model legume Medicago truncatula produces >700 nodule specific cysteine-rich (NCR) peptides in symbiosis and many of them have in vitro antimicrobial activities without considerable toxicity on human cells. In this work we demonstrate the anticandidal activity of the NCR335 and NCR169 peptide derivatives against five Candida species by using the micro-dilution method, measuring inhibition of biofilm formation with the XTT (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide) assay, and assessing the morphological change of dimorphic Candida species by microscopy. We show that both the N- and C-terminal regions of NCR335 possess anticandidal activity as well as the C-terminal sequence of NCR169. The active peptides inhibit biofilm formation and the yeast-hypha transformation. Combined treatment of C. auris with peptides and fluconazole revealed synergistic interactions and reduced 2-8-fold the minimal inhibitory concentrations. Our results demonstrate that shortening NCR peptides can even enhance and broaden their anticandidal activity and therapeutic potential.

Anticandidal activity of Pseudomonas aeruginosa strains isolated from clinical specimens

Mycoses ◽  
2007 ◽  
Vol 50 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Ilknur Kaleli ◽  
Nural Cevahir ◽  
Melek Demir ◽  
Umut Yildirim ◽  
Rasim Sahin
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Clinical Specimens ◽  
Anticandidal Activity

scholarly journals ENDOPHYTIC BACTERIA DIVERSITY FROM ZINGIBERACEAE AND ANTICANDIDAL CHARACTERIZATION PRODUCED BY Pseudomonas helmanticensis

2020 ◽  
Vol 83 (1) ◽  
pp. 7-17
Author(s):  
Tri Ratna Sulistiyani ◽  
Masrukhin Masrukhin ◽  
Ismu Purnaningsih ◽  
Toga Pangihotan Napitupulu ◽  
Agus Budiyanto ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Endophytic Bacteria ◽  
Gene Sequence ◽  
Inhibitory Concentration ◽  
Cell Number ◽  
Membrane Disruption ◽  
Rrna Gene ◽  
The Novel ◽  
Gene Sequence Analysis ◽  
Anticandidal Activity

Endophytic microbes are sources for the novel antibiotic. We isolated endophytic bacteria from Zingiberaceae collected from West Sulawesi, Indonesia, and investigated their anticandidal activity. Molecular identification of the isolates was done using 16S rRNA gene sequence analysis. The antimicrobial activity was tested against four bacteria and one yeast. The anticandidal compound of selected bacteria was extracted using three different solvents (chloroform, ethyl acetate, and methanol), and each fraction was tested for their anticandidal activity. Anticandidal minimum inhibitory concentration (MIC) was determined with concentration ranging from 300 to 18.75 μg/mL, and the morphology of the Candida cells after treatment was confirmed by scanning electron microscope (SEM). The identification of anticandidal compounds was conducted using GC-MS. A total of 24 isolates were collected from Zingiberaceae plants. There were 14 genera and 19 species belonging to Gammaproteobacteria (66.67%), Alphaproteobacteria (25.00%), Actinobacteria (4.17%), Bacteriodetes (4.17%), and a new record for Lelliottia aquatilis as an endophytic bacteria. One of 24 isolates identified as Pseudomonas helmanticensis isolated from Alpinia melichroa showed anticandidal activity. Ethyl acetate was the appropriate solvent to extract the anticandidal compounds. Diisooctyl phthalate was found as the most abundant compound in the extract for the anticandidal activity. An increase in extract concentration did not reduce the Candida cell number. The extract treatment showed membrane disruption of Candida albicans cells. We propose that active compounds from P. helmanticensis are potential as anticandidal sources and could be explored more for the pharmaceutical industry. 

Transport of antimicrobial agents using peptide carrier systems: anticandidal activity of m-fluorophenylalanine-peptide conjugates

1983 ◽  
Vol 26 (12) ◽  
pp. 1725-1729 ◽  
Author(s):  
William D. Kingsbury ◽  
Jeffrey C. Boehm ◽  
Rajanikant J. Mehta ◽  
Sarah F. Grappel
Keyword(s):  
Antimicrobial Agents ◽  
Peptide Conjugates ◽  
Peptide Carrier ◽  
Anticandidal Activity ◽  
Carrier Systems

Synthesis, Characterization and X-Ray Crystal Structure of the New Schiff Base and Anticandidal Evaluation

2019 ◽  
Vol 41 (6) ◽  
pp. 1090-1090
Author(s):  
Mehmet Poyraz Mehmet Poyraz ◽  
Musa Sari Musa Sari ◽  
Halil Berber Halil Berber ◽  
Nursenem Karaca and Fatih Demirci Nursenem Karaca and Fatih Demirci
Keyword(s):  
Schiff Base ◽  
Spectroscopic Techniques ◽  
X Ray Diffraction ◽  
X Ray ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Ft Ir ◽  
Anticandidal Activity ◽  
Crystal Structural

A new Schiff base, namely 2-methoxy-6-((2-(4 nitrophenyl) hydrazineylidene) methyl)phenol was synthesized and characterized by melting points, elemental analysis, thermogravimetric analysis and spectroscopic techniques (FT-IR, 1H-NMR and UV-VIS spectra). The chemical structure of compound was further confirmed by single crystal structural X-ray diffraction. The Schiff base is crystallized in the triclinic space group P-1. In the crystal, molecules are linked by O-H…O hydrogen bonds between the hydroxy “-O-” atom and the methoxy “-O-” atom. Furthermore, the synthesized Schiff base was tested for the in vitro anticandidal activities using CLSI broth microdilution method against human pathogenic Candida albicans, C. parapsilosis and C. krusei standard strains. In the anticandidal activity test results, the new Schiff base was found to be effective at 1 mg/mL - 0.25 mg/mL concentrations. (The last line omitted) (The sentence marked in red will be deleted)

scholarly journals Anticandidal activity of Lactobacillus spp. in the presence of galactosyl polyols

2020 ◽  
Vol 240 ◽  
pp. 126540
Author(s):  
Lidia Lipinska-Zubrycka ◽  
Robert Klewicki ◽  
Michal Sojka ◽  
Radoslaw Bonikowski ◽  
Agnieszka Milczarek ◽  
...  
Keyword(s):  
Anticandidal Activity ◽  
Lactobacillus Spp

scholarly journals New group of azastilbene analogs of resveratrol: Synthesis, anticandidal activity and toxicity evaluation

2019 ◽  
Vol 31 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Francislene Juliana Martins ◽  
Mônica Senra ◽  
César Augusto Caneschi ◽  
Juliana Alves dos Santos ◽  
Adilson David da Silva ◽  
...  
Keyword(s):  
Toxicity Evaluation ◽  
Anticandidal Activity
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