Synthesis and study of conformationally defined enantiomers of local anesthetics and conformationally defined enantiomers of fluorescent dyes designed to label electrically excitable membranes

1980 ◽  
Vol 23 (3) ◽  
pp. 282-285 ◽  
Author(s):  
Henry G. Mautner ◽  
Carol Lorenc ◽  
Paul Quain ◽  
Judith K. Marquis ◽  
Ichiji Tasaki
Keyword(s):  
Local Anesthetics ◽  
Fluorescent Dyes ◽  
Excitable Membranes ◽  
Electrically Excitable Membranes

scholarly journals CHARACTERIZATION OF A UNIQUE MUSCLE CELL LINE

1974 ◽  
Vol 61 (2) ◽  
pp. 398-413 ◽  
Author(s):  
David Schubert ◽  
A. John Harris ◽  
Carrick E. Devine ◽  
Stephen Heinemann
Keyword(s):  
Smooth Muscle ◽  
Cell Line ◽  
Action Potentials ◽  
Creatine Phosphokinase ◽  
Clonal Cell Line ◽  
Excitable Membranes ◽  
Hyperpolarizing Response ◽  
Electrically Excitable Membranes

A clonal cell line derived from a mouse neoplasm is described which shares many properties with smooth muscle. The cells have electrically excitable membranes capable of generating overshooting action potentials, and they contract both spontaneously and with electrical stimulation. They respond to the iontophoretic application of acetylcholine with a depolarizing response, and to norepinephrine with a hyperpolarizing response. Electron microscopy reveals that the cells have a morphology similar in many, but not all, respects to that of smooth muscle cells in vivo. The cells secrete soluble collagen-like molecules in addition to several proteins of undefined function. Finally, there is an increase in the specific activities of creatine phosphokinase and myokinase associated with increased cell density and the cessation of cell division.

Effect of pyromecaine on ionic currents of electrically excitable membranes

1985 ◽  
Vol 100 (5) ◽  
pp. 1536-1539
Author(s):  
E. I. Nazarov ◽  
N. T. Pryanishnikova ◽  
L. I. Pavlova ◽  
V. G. Vongai
Keyword(s):  
Ionic Currents ◽  
Excitable Membranes ◽  
Electrically Excitable Membranes

scholarly journals Isologous Oxygen, Sulfur, and Selenium Compounds as Probes of Acetylcholine Receptors

1969 ◽  
Vol 54 (1) ◽  
pp. 271-277 ◽  
Author(s):  
Henry G. Mautner
Keyword(s):  
Local Anesthetics ◽  
Acetylcholine Receptors ◽  
Active Sites ◽  
Selenium Compounds ◽  
Excitable Membranes ◽  
Electric Eel

Evidence is presented that while the conformations of acetylcholine and acetylthiolcholine are different, acetylthiolcholine and acetylselenolcholine are structurally and conformationally very similar. Experiments with sulfur and selenium isologs of acetylcholine, choline, and local anesthetics suggest that the active sites of receptors of the electroplax and of electric eel acetylcholinesterase are different, but are compatible with the postulate that acetylcholine receptors of axonal and synaptic excitable membranes are similar.

The Mechanism of Acute Neuromuscular Weakness Induced by Chloroquine

1972 ◽  
Vol 50 (11) ◽  
pp. 1099-1103 ◽  
Author(s):  
G. A. Vartanian ◽  
H. M. Chinyanga
Keyword(s):  
Clinical Practice ◽  
Muscle Weakness ◽  
Muscle Fiber ◽  
Mechanism Of Action ◽  
Action Potentials ◽  
Nerve Fibers ◽  
End Plate ◽  
Excitable Membranes ◽  
Single Nerve ◽  
Electrically Excitable Membranes

Chloroquine caused muscle weakness in neuromuscular preparations of both frog and cat in doses as low as those used in clinical practice. Studies of end-plate and action potentials in the muscle fibers and action potentials in single nerve fibers showed that the muscle weakness induced by chloroquine resulted from depression of the excitability of the electrically excitable membranes of the axon and muscle fiber. This led to the decrease of action potentials of the axon resulting in the reduction of transmitter output at the end plate and decreased firing index, as well as to the decrease in the amplitude of action potential of the muscle fiber itself. It was inferred that the mechanism of action of chloroquine was similar to that of local anesthetics.

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