Effect of pyromecaine on ionic currents of electrically excitable membranes

1985 ◽  
Vol 100 (5) ◽  
pp. 1536-1539
Author(s):  
E. I. Nazarov ◽  
N. T. Pryanishnikova ◽  
L. I. Pavlova ◽  
V. G. Vongai
Keyword(s):  
Ionic Currents ◽  
Excitable Membranes ◽  
Electrically Excitable Membranes

scholarly journals Monolayer and Interfacial Permeation

1968 ◽  
Vol 52 (1) ◽  
pp. 191-208 ◽  
Author(s):  
Martin Blank
Keyword(s):  
Partition Coefficients ◽  
Cell Membranes ◽  
Lung Surfactant ◽  
Ionic Currents ◽  
Ionic Selectivity ◽  
Ionic Fluxes ◽  
Dimensional Network ◽  
Excitable Membranes ◽  
Biological Interfaces ◽  
Alveolar Stability

Transport across physical-chemical interfaces is considered in connection with three particular problems of biological interfaces: the structure and properties of cell membranes, the properties of the lung surfactant, and the effects of ionic currents across excitable membranes. With regard to cell membranes, studies of monolayer permeation suggest that permselectivity on the basis of size is a property of bilayer structure and probably gives rise to the observed dependence of the permeability on partition coefficients. The permeabilities of lipid and protein monolayers are consistent with the bimolecular leaflet (BML) model of the membrane and not with mosaic models. Experiments with the lung surfactant indicate that, in addition to its surface tension-lowering properties, it is unusual in its ability to form a strong two-dimensional network, which probably contributes to alveolar stability. Finally, the results of studies of interfacial ionic transference suggest a new way of accounting for the ionic fluxes in excitable membranes during an action potential without assuming ion-selective pores or carriers. In the suggested mechanism, it is possible to account for the change in ionic selectivity and the proper phasing of the fluxes, as well as other aspects of excitation in natural membranes.

scholarly journals CHARACTERIZATION OF A UNIQUE MUSCLE CELL LINE

1974 ◽  
Vol 61 (2) ◽  
pp. 398-413 ◽  
Author(s):  
David Schubert ◽  
A. John Harris ◽  
Carrick E. Devine ◽  
Stephen Heinemann
Keyword(s):  
Smooth Muscle ◽  
Cell Line ◽  
Action Potentials ◽  
Creatine Phosphokinase ◽  
Clonal Cell Line ◽  
Excitable Membranes ◽  
Hyperpolarizing Response ◽  
Electrically Excitable Membranes

A clonal cell line derived from a mouse neoplasm is described which shares many properties with smooth muscle. The cells have electrically excitable membranes capable of generating overshooting action potentials, and they contract both spontaneously and with electrical stimulation. They respond to the iontophoretic application of acetylcholine with a depolarizing response, and to norepinephrine with a hyperpolarizing response. Electron microscopy reveals that the cells have a morphology similar in many, but not all, respects to that of smooth muscle cells in vivo. The cells secrete soluble collagen-like molecules in addition to several proteins of undefined function. Finally, there is an increase in the specific activities of creatine phosphokinase and myokinase associated with increased cell density and the cessation of cell division.

The Mechanism of Acute Neuromuscular Weakness Induced by Chloroquine

1972 ◽  
Vol 50 (11) ◽  
pp. 1099-1103 ◽  
Author(s):  
G. A. Vartanian ◽  
H. M. Chinyanga
Keyword(s):  
Clinical Practice ◽  
Muscle Weakness ◽  
Muscle Fiber ◽  
Mechanism Of Action ◽  
Action Potentials ◽  
Nerve Fibers ◽  
End Plate ◽  
Excitable Membranes ◽  
Single Nerve ◽  
Electrically Excitable Membranes

Chloroquine caused muscle weakness in neuromuscular preparations of both frog and cat in doses as low as those used in clinical practice. Studies of end-plate and action potentials in the muscle fibers and action potentials in single nerve fibers showed that the muscle weakness induced by chloroquine resulted from depression of the excitability of the electrically excitable membranes of the axon and muscle fiber. This led to the decrease of action potentials of the axon resulting in the reduction of transmitter output at the end plate and decreased firing index, as well as to the decrease in the amplitude of action potential of the muscle fiber itself. It was inferred that the mechanism of action of chloroquine was similar to that of local anesthetics.

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