DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain

Kisione K. Valu; Trudi A. Gourdie; Theodore J. Boritzki; G. Lance Gravatt; Bruce C. Baguley; William R. Wilson; Laurence P. G. Wakelin; Paul D. Woodgate; William A. Denny

doi:10.1021/jm00173a016

DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain

Journal of Medicinal Chemistry ◽

10.1021/jm00173a016 ◽

1990 ◽

Vol 33 (11) ◽

pp. 3014-3019 ◽

Cited By ~ 29

Author(s):

Kisione K. Valu ◽

Trudi A. Gourdie ◽

Theodore J. Boritzki ◽

G. Lance Gravatt ◽

Bruce C. Baguley ◽

...

Keyword(s):

Alkylating Agents ◽

Structure Activity Relationships ◽

Linker Chain ◽

Structure Activity

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Antimitotic Antitumor Agents: Synthesis, Structure−Activity Relationships, and Biological Characterization ofN-Aryl-N‘-(2-chloroethyl)ureas as New Selective Alkylating Agents

Journal of Medicinal Chemistry ◽

10.1021/jm0010264 ◽

2001 ◽

Vol 44 (5) ◽

pp. 694-702 ◽

Cited By ~ 53

Author(s):

Emmanuelle Mounetou ◽

Jean Legault ◽

Jacques Lacroix ◽

René C-Gaudreault

Keyword(s):

Antitumor Agents ◽

Alkylating Agents ◽

Biological Characterization ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Antimitotic Antitumor Agents: Synthesis, Structure-Activity Relationships, and Biological Characterization of N-Aryl-N′-(2-chloroethyl)ureas as New Selective Alkylating Agents.

ChemInform ◽

10.1002/chin.200125095 ◽

2010 ◽

Vol 32 (25) ◽

pp. no-no

Author(s):

Emmanuelle Mounetou ◽

Jean Legault ◽

Jacques Lacroix ◽

Rene C-Gaudreault

Keyword(s):

Antitumor Agents ◽

Alkylating Agents ◽

Biological Characterization ◽

Structure Activity Relationships ◽

Structure Activity

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DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard

Journal of Medicinal Chemistry ◽

10.1021/jm00166a015 ◽

1990 ◽

Vol 33 (4) ◽

pp. 1177-1186 ◽

Cited By ~ 54

Author(s):

Trudi A. Gourdie ◽

Kisione K. Valu ◽

G. Lance Gravatt ◽

Theodore J. Boritzki ◽

Bruce C. Baguley ◽

...

Keyword(s):

Alkylating Agents ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis of 1-Substituted 3-(Chloromethyl)-6-aminoindoline (6-Amino-seco-CI) DNA Minor Groove Alkylating Agents and Structure−Activity Relationships for Their Cytotoxicity

Journal of Medicinal Chemistry ◽

10.1021/jm980545s ◽

1999 ◽

Vol 42 (4) ◽

pp. 649-658 ◽

Cited By ~ 27

Author(s):

Jared B. J. Milbank ◽

Moana Tercel ◽

Graham J. Atwell ◽

William R. Wilson ◽

Alison Hogg ◽

...

Keyword(s):

Alkylating Agents ◽

Minor Groove ◽

Dna Minor Groove ◽

Structure Activity Relationships ◽

Structure Activity

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STRUCTURE-ACTIVITY RELATIONSHIPS OF ALKYLATING AGENTS IN CANCER CHEMOTHERAPY

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1969.tb24916.x ◽

1969 ◽

Vol 163 (2 Biological Ef) ◽

pp. 1006-1025 ◽

Cited By ~ 41

Author(s):

T. J. Bardos ◽

Z. F. Chmielewicz ◽

P. Hebborn

Keyword(s):

Cancer Chemotherapy ◽

Alkylating Agents ◽

Structure Activity Relationships ◽

Structure Activity

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Structure−Activity Relationships for 4-Nitrobenzyl Carbamates of 5-Aminobenz[e]indoline Minor Groove Alkylating Agents as Prodrugs for GDEPT in Conjunction withE.coliNitroreductase

Journal of Medicinal Chemistry ◽

10.1021/jm0205191 ◽

2003 ◽

Vol 46 (12) ◽

pp. 2456-2466 ◽

Cited By ~ 22

Author(s):

Michael P. Hay ◽

Graham J. Atwell ◽

William R. Wilson ◽

Susan M. Pullen ◽

William A. Denny

Keyword(s):

Alkylating Agents ◽

Minor Groove ◽

Structure Activity Relationships ◽

Structure Activity

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2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 2. Structure–activity relationships of the linker chain

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(01)01291-0 ◽

2002 ◽

Vol 37 (1) ◽

pp. 83-89 ◽

Cited By ~ 4

Author(s):

Klaus Müller ◽

Reinhold Altmann ◽

Helge Prinz

Keyword(s):

Structure Activity Relationships ◽

Linker Chain ◽

Structure Activity ◽

12 Lipoxygenase

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ChemInform Abstract: 2-Arylalkyl-Substituted Anthracenones as Inhibitors of 12-Lipoxygenase Enzymes. Part 2. Structure-Activity Relationships of the Linker Chain.

ChemInform ◽

10.1002/chin.200225092 ◽

2010 ◽

Vol 33 (25) ◽

pp. no-no

Author(s):

Klaus Mueller ◽

Reinhold Altmann ◽

Helge Prinz

Keyword(s):

Structure Activity Relationships ◽

Linker Chain ◽

Structure Activity ◽

12 Lipoxygenase

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Structure-Activity Relationships of MDMA-Like Substances

PsycEXTRA Dataset ◽

10.1037/e496472006-001 ◽

1989 ◽

Cited By ~ 3

Author(s):

David E. Nichols ◽

◽

Robert Oberlender

Keyword(s):

Structure Activity Relationships ◽

Structure Activity

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Structure-Activity Relationships in Cannabinoids: An Overview

PsycEXTRA Dataset ◽

10.1037/e496672006-002 ◽

1987 ◽

Author(s):

Raj K. Razdan ◽

Keyword(s):

Structure Activity Relationships ◽

Structure Activity

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