New synthesis of N-[4-[[(2-amino-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives

1981 ◽  
Vol 24 (10) ◽  
pp. 1254-1258 ◽  
Author(s):  
Carroll Temple ◽  
C. L. Kussner ◽  
J. D. Rose ◽  
D. L. Smithers ◽  
L. L. Bennett ◽  
...  
Keyword(s):  
1931 ◽  
Vol 94 (2) ◽  
pp. 599-609
Author(s):  
Max S. Dunn ◽  
B.W. Smart ◽  
C.E. Redemann ◽  
K.E. Brown
Keyword(s):  

1956 ◽  
Vol 34 (10) ◽  
pp. 1440-1443 ◽  
Author(s):  
Guy Talbot ◽  
Roger Gaudry ◽  
Louis Berlinguet

A new synthesis of DL-glutamic acid was carried out in an over-all yield of 87% from condensation between β-propiolactone and the sodium salt of diethyl acetamidomalonate, followed by acid hydrolysis. When desired, the intermediate product, the diethyl ester of N-acetyl-2-carbethoxyglutamic acid, could be isolated in a 68% yield and hydrolyzed to glutamic acid via the hydrochloride in a 95% yield.


1969 ◽  
Vol 47 (19) ◽  
pp. 3690-3693 ◽  
Author(s):  
J. Kovacs ◽  
G. N. Schmit ◽  
B. J. Johnson

A new synthesis of native polyglutamic acid is described through the polycondensation of γ-glutamylglutamic acid-α,α′-di-t-butyl-γ-pentachlorophenyl ester. This route eliminates the possibility of transpeptidation.


1971 ◽  
Vol 12 (3) ◽  
pp. 263-266 ◽  
Author(s):  
Kenji Koga ◽  
Masao Taniguchi ◽  
Shun-ichi Yamada
Keyword(s):  

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