Configuration and preferential solid-state conformations of perindoprilat (S-9780). Comparison with the crystal structures of other ACE inhibitors and conclusions related to structure-activity relationships

1991 ◽  
Vol 34 (2) ◽  
pp. 663-669 ◽  
Author(s):  
Claudine Pascard ◽  
Jean Guilhem ◽  
Michel Vincent ◽  
Georges Remond ◽  
Bernard Portevin ◽  
...  
Keyword(s):  
Solid State ◽  
Crystal Structures ◽  
Ace Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity

Sila-Pharmaka, 26. Mitt. [1]. Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III / Sila-Pharmaca, 26th Communication [1]. Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III

1982 ◽  
Vol 37 (11) ◽  
pp. 1461-1471 ◽  
Author(s):  
Reinhold Tacke ◽  
Haryanto Linoh ◽  
Moayad T. Attar-Bashi ◽  
William S. Sheldrick ◽  
Ludger Ernst ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
X Ray Diffraction ◽  
Silicon Compounds ◽  
X Ray ◽  
Structure Activity Relationships ◽  
H Nmr ◽  
Structure Activity

The potentially curare-like silicon compounds 8a-8f wore synthesized and investigated with respect to their structure-activity relationships. The conformations of the com­pounds in the solid state and in solution were studied by X-ray diffraction analysis (8a-8e) and 1H NMR spectroscopy (8a-8f), respectively. The muscle relaxing properties of 8a-8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical “14 Å model” for neuromuscular blocking agents.

scholarly journals Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

2014 ◽  
Vol 5 (10) ◽  
pp. 1119-1123 ◽  
Author(s):  
Shingo Tojo ◽  
Tetsuya Kohno ◽  
Tomoyuki Tanaka ◽  
Seiji Kamioka ◽  
Yosuke Ota ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Structure Activity Relationships ◽  
Structure Activity
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